Matches in SemOpenAlex for { <https://semopenalex.org/work/W3102900934> ?p ?o ?g. }
- W3102900934 endingPage "58" @default.
- W3102900934 startingPage "52" @default.
- W3102900934 abstract "Background and aimsHeterozygous familial hypercholesterolemia (FH) is associated with premature atherosclerotic cardiovascular disease. Semi-automated plaque characterization (SAPC) by coronary computed tomographic angiography (CTA) provides information regarding coronary plaque burden and plaque characterization. Our aim was to quantify and characterize the coronary plaque burden of patients with FH using SAPC analysis and to identify which factors are related to plaque burden and plaque characteristics. A second aim was to analyse the prognostic implications of these parameters.MethodsTwo hundred and fifty-nine asymptomatic individuals with molecularly determined FH were enrolled in this follow-up cohort study and underwent a coronary CTA analysed with SAPC.ResultsMean follow-up time after coronary CTA was 3.9 ± 2 years. Mean age was 46.9 (10.7) years (130 women, 50.2%). Median plaque burden was 25.0% (19.0–29.0), non-calcified plaque burden 22.83% (17.94–26.88), calcified plaque-burden 1.12% (0.31–2.86) and CCS 8.9 (0–93). Five-year risk was independently related to plaque burden, non-calcified plaque burden, calcified plaque burden and coronary calcium score (B:3.75, 95%CI:2.92–4.58; p < 0.001, B:2.9, 95%CI:2.15–3.66; p < 0.001, B:0.75, 95%CI 0.4–1.1; p < 0.001 and B:82.2, 95%CI:49.28–115.16; p < 0.001 respectively). During follow-up, there were 15 (5.81%) nonfatal events and 1 (0.4%) fatal event. Plaque burden was significantly related to event-free survival during follow-up (HR:1.11; 95%CI:1.05–1.18; p < 0.001).ConclusionsCoronary atherosclerosis and its qualitative components may be quantified by means of SAPC in patients with FH. Plaque burden, calcified plaque burden and non-calcified plaque burden were independently related to the estimated cardiovascular risk. Plaque burden was also related to prognosis." @default.
- W3102900934 created "2020-11-23" @default.
- W3102900934 creator A5001787456 @default.
- W3102900934 creator A5015329406 @default.
- W3102900934 creator A5018981107 @default.
- W3102900934 creator A5032916948 @default.
- W3102900934 creator A5035161501 @default.
- W3102900934 creator A5035352022 @default.
- W3102900934 creator A5058100820 @default.
- W3102900934 creator A5059046557 @default.
- W3102900934 creator A5064420882 @default.
- W3102900934 creator A5070499961 @default.
- W3102900934 creator A5072747894 @default.
- W3102900934 creator A5077151586 @default.
- W3102900934 creator A5078895404 @default.
- W3102900934 creator A5089419937 @default.
- W3102900934 date "2021-01-01" @default.
- W3102900934 modified "2023-10-12" @default.
- W3102900934 title "Coronary plaque burden, plaque characterization and their prognostic implications in familial hypercholesterolemia: A computed tomographic angiography study" @default.
- W3102900934 cites W1838851706 @default.
- W3102900934 cites W1844854928 @default.
- W3102900934 cites W1996344483 @default.
- W3102900934 cites W2054455620 @default.
- W3102900934 cites W2083077872 @default.
- W3102900934 cites W2121363804 @default.
- W3102900934 cites W2129725309 @default.
- W3102900934 cites W2133841044 @default.
- W3102900934 cites W2152705713 @default.
- W3102900934 cites W2165624352 @default.
- W3102900934 cites W2166910397 @default.
- W3102900934 cites W2298508936 @default.
- W3102900934 cites W2558499107 @default.
- W3102900934 cites W2620146310 @default.
- W3102900934 cites W2800105293 @default.
- W3102900934 cites W2894591464 @default.
- W3102900934 cites W2897540422 @default.
- W3102900934 cites W2901265933 @default.
- W3102900934 cites W2921836078 @default.
- W3102900934 cites W3009059316 @default.
- W3102900934 cites W316258779 @default.
- W3102900934 cites W4206728774 @default.
- W3102900934 cites W56038340 @default.
- W3102900934 cites W880085211 @default.
- W3102900934 doi "https://doi.org/10.1016/j.atherosclerosis.2020.11.012" @default.
- W3102900934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33261814" @default.
- W3102900934 hasPublicationYear "2021" @default.
- W3102900934 type Work @default.
- W3102900934 sameAs 3102900934 @default.
- W3102900934 citedByCount "9" @default.
- W3102900934 countsByYear W31029009342021 @default.
- W3102900934 countsByYear W31029009342022 @default.
- W3102900934 countsByYear W31029009342023 @default.
- W3102900934 crossrefType "journal-article" @default.
- W3102900934 hasAuthorship W3102900934A5001787456 @default.
- W3102900934 hasAuthorship W3102900934A5015329406 @default.
- W3102900934 hasAuthorship W3102900934A5018981107 @default.
- W3102900934 hasAuthorship W3102900934A5032916948 @default.
- W3102900934 hasAuthorship W3102900934A5035161501 @default.
- W3102900934 hasAuthorship W3102900934A5035352022 @default.
- W3102900934 hasAuthorship W3102900934A5058100820 @default.
- W3102900934 hasAuthorship W3102900934A5059046557 @default.
- W3102900934 hasAuthorship W3102900934A5064420882 @default.
- W3102900934 hasAuthorship W3102900934A5070499961 @default.
- W3102900934 hasAuthorship W3102900934A5072747894 @default.
- W3102900934 hasAuthorship W3102900934A5077151586 @default.
- W3102900934 hasAuthorship W3102900934A5078895404 @default.
- W3102900934 hasAuthorship W3102900934A5089419937 @default.
- W3102900934 hasBestOaLocation W31029009341 @default.
- W3102900934 hasConcept C126322002 @default.
- W3102900934 hasConcept C126838900 @default.
- W3102900934 hasConcept C164705383 @default.
- W3102900934 hasConcept C2777910003 @default.
- W3102900934 hasConcept C2778213512 @default.
- W3102900934 hasConcept C2778710248 @default.
- W3102900934 hasConcept C2780643987 @default.
- W3102900934 hasConcept C2983858294 @default.
- W3102900934 hasConcept C3018127138 @default.
- W3102900934 hasConcept C500558357 @default.
- W3102900934 hasConcept C71924100 @default.
- W3102900934 hasConcept C72563966 @default.
- W3102900934 hasConceptScore W3102900934C126322002 @default.
- W3102900934 hasConceptScore W3102900934C126838900 @default.
- W3102900934 hasConceptScore W3102900934C164705383 @default.
- W3102900934 hasConceptScore W3102900934C2777910003 @default.
- W3102900934 hasConceptScore W3102900934C2778213512 @default.
- W3102900934 hasConceptScore W3102900934C2778710248 @default.
- W3102900934 hasConceptScore W3102900934C2780643987 @default.
- W3102900934 hasConceptScore W3102900934C2983858294 @default.
- W3102900934 hasConceptScore W3102900934C3018127138 @default.
- W3102900934 hasConceptScore W3102900934C500558357 @default.
- W3102900934 hasConceptScore W3102900934C71924100 @default.
- W3102900934 hasConceptScore W3102900934C72563966 @default.
- W3102900934 hasFunder F4320323479 @default.
- W3102900934 hasFunder F4320334923 @default.
- W3102900934 hasLocation W31029009341 @default.
- W3102900934 hasOpenAccess W3102900934 @default.
- W3102900934 hasPrimaryLocation W31029009341 @default.
- W3102900934 hasRelatedWork W1963729857 @default.