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• W3102973997 abstract "Signaling pathway between human leukocyte antigen (HLA)-G and immune inhibitory receptors immunoglobulin-like transcript (ILT)-2/4 has been acknowledged as one of immune checkpoints, and as a potential target for cancer immunotherapy. Like other immune checkpoints, inter- and even intra-tumor heterogeneity of HLA-G could render a rather complexity for HLA-G-target immunotherapy. However, little information for intra-tumor heterogeneity of HLA-G is available. In this study, HLA-G expression in a serial section of colorectal cancer (CRC) lesions from three CRC patients (each sample with serial section of 50 slides, 10 randomized slides for each antibody), three different locations within a same sample (five CRC), and three case-matched blocks that each includes 36 esophageal cancer samples, were evaluated with immunohistochemistry using anti-HLA-G antibodies (mAbs 4H84, MEM-G/1 and MEM-G/2 probing for all denatured HLA-G isoforms, 5A6G7 and 2A12 probing for denatured HLA-G5 and HLA-G6 isoforms). Our results revealed that, in addition to the frequently observed inter-tumor heterogeneity, intra-tumor heterogeneous expression of HLA-G is common in different areas within a tumor in CRC and esophageal cancer samples included in this study. Moreover, percentage of HLA-G expression probed with different anti-HLA-G antibodies also varies dramatically within a tumor. Given HLA-G has been considered as an important immune checkpoint, intra-tumor heterogeneity of HLA-G expression, and different specificity of anti-HLA-G antibodies being used among studies, interpretation and clinical significance of HLA-G expression in cancers should be with caution." @default.
• W3102973997 created "2020-11-23" @default.
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• W3102973997 date "2020-11-19" @default.
• W3102973997 modified "2023-10-16" @default.
• W3102973997 title "Intratumor Heterogeneity of HLA-G Expression in Cancer Lesions" @default.
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• W3102973997 doi "https://doi.org/10.3389/fimmu.2020.565759" @default.
• W3102973997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7717930" @default.
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