Matches in SemOpenAlex for { <https://semopenalex.org/work/W3102995741> ?p ?o ?g. }
- W3102995741 endingPage "21612" @default.
- W3102995741 startingPage "21597" @default.
- W3102995741 abstract "Breast cancer is one of the most lethal malignancies among women, and understanding the effects of host immunity on disease progression offers the potential to improve immunotherapies against it. Here, we constructed an immunity-related gene (IRG)-based prognostic signature to stratify breast cancer patients and predict their survival. We identified differentially-expressed genes by analyzing the breast cancer transcriptome data from The Cancer Genome Atlas. Univariate Cox regression revealed 179 survival-correlated IRGs, 12 of which we used to construct an immunity-based prognostic signature that stratified breast cancer patients into high- and low-risk groups. The signature was an independent predictor for survival and was validated in an independent dataset. We also investigated the correlations between our prognostic signature and immune infiltrates and found that signature-derived risk scores correlated negatively with infiltration of B cells, CD4+ T cells, CD8+ T cells, neutrophils and dendritic cells. Our results show that the proposed prognostic signature reflects the tumor immune microenvironment, which makes it a potential indicator for survival that warrants further research to assess its clinical utility." @default.
- W3102995741 created "2020-11-23" @default.
- W3102995741 creator A5006416068 @default.
- W3102995741 creator A5048881400 @default.
- W3102995741 creator A5056078581 @default.
- W3102995741 creator A5063346114 @default.
- W3102995741 creator A5074967184 @default.
- W3102995741 creator A5075883718 @default.
- W3102995741 creator A5084508812 @default.
- W3102995741 date "2020-11-07" @default.
- W3102995741 modified "2023-10-06" @default.
- W3102995741 title "Construction and validation of an immunity-related prognostic signature for breast cancer" @default.
- W3102995741 cites W1982273978 @default.
- W3102995741 cites W1983591605 @default.
- W3102995741 cites W1991830271 @default.
- W3102995741 cites W1998767819 @default.
- W3102995741 cites W2000272838 @default.
- W3102995741 cites W2004630197 @default.
- W3102995741 cites W2025738474 @default.
- W3102995741 cites W2030135652 @default.
- W3102995741 cites W2031941215 @default.
- W3102995741 cites W2043723361 @default.
- W3102995741 cites W2044227662 @default.
- W3102995741 cites W2048270768 @default.
- W3102995741 cites W2049088975 @default.
- W3102995741 cites W2073052482 @default.
- W3102995741 cites W2096283457 @default.
- W3102995741 cites W2098683355 @default.
- W3102995741 cites W2112434826 @default.
- W3102995741 cites W2112648444 @default.
- W3102995741 cites W2114027214 @default.
- W3102995741 cites W2114505219 @default.
- W3102995741 cites W2118278569 @default.
- W3102995741 cites W2118531126 @default.
- W3102995741 cites W2120338564 @default.
- W3102995741 cites W2133439754 @default.
- W3102995741 cites W2134878729 @default.
- W3102995741 cites W2138694950 @default.
- W3102995741 cites W2149479626 @default.
- W3102995741 cites W2156070874 @default.
- W3102995741 cites W2158217645 @default.
- W3102995741 cites W2221588520 @default.
- W3102995741 cites W2294216513 @default.
- W3102995741 cites W2345395916 @default.
- W3102995741 cites W2509891798 @default.
- W3102995741 cites W2518752141 @default.
- W3102995741 cites W2557970176 @default.
- W3102995741 cites W2584623346 @default.
- W3102995741 cites W2597268880 @default.
- W3102995741 cites W2608458533 @default.
- W3102995741 cites W2744067212 @default.
- W3102995741 cites W2764195760 @default.
- W3102995741 cites W2765224588 @default.
- W3102995741 cites W2765480297 @default.
- W3102995741 cites W2789815300 @default.
- W3102995741 cites W2801501414 @default.
- W3102995741 cites W2805900947 @default.
- W3102995741 cites W2892890999 @default.
- W3102995741 cites W2903894207 @default.
- W3102995741 cites W2906052725 @default.
- W3102995741 cites W2916659228 @default.
- W3102995741 cites W2947251899 @default.
- W3102995741 cites W2953219174 @default.
- W3102995741 cites W2956009760 @default.
- W3102995741 cites W2957360688 @default.
- W3102995741 cites W2968004322 @default.
- W3102995741 cites W2975275397 @default.
- W3102995741 cites W2990553464 @default.
- W3102995741 cites W2999417355 @default.
- W3102995741 cites W3004381276 @default.
- W3102995741 doi "https://doi.org/10.18632/aging.103952" @default.
- W3102995741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7695418" @default.
- W3102995741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33216733" @default.
- W3102995741 hasPublicationYear "2020" @default.
- W3102995741 type Work @default.
- W3102995741 sameAs 3102995741 @default.
- W3102995741 citedByCount "8" @default.
- W3102995741 countsByYear W31029957412021 @default.
- W3102995741 countsByYear W31029957412022 @default.
- W3102995741 countsByYear W31029957412023 @default.
- W3102995741 crossrefType "journal-article" @default.
- W3102995741 hasAuthorship W3102995741A5006416068 @default.
- W3102995741 hasAuthorship W3102995741A5048881400 @default.
- W3102995741 hasAuthorship W3102995741A5056078581 @default.
- W3102995741 hasAuthorship W3102995741A5063346114 @default.
- W3102995741 hasAuthorship W3102995741A5074967184 @default.
- W3102995741 hasAuthorship W3102995741A5075883718 @default.
- W3102995741 hasAuthorship W3102995741A5084508812 @default.
- W3102995741 hasBestOaLocation W31029957411 @default.
- W3102995741 hasConcept C121608353 @default.
- W3102995741 hasConcept C126322002 @default.
- W3102995741 hasConcept C143998085 @default.
- W3102995741 hasConcept C203014093 @default.
- W3102995741 hasConcept C2524010 @default.
- W3102995741 hasConcept C2779341262 @default.
- W3102995741 hasConcept C2779696439 @default.
- W3102995741 hasConcept C33923547 @default.
- W3102995741 hasConcept C530470458 @default.