Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103030515> ?p ?o ?g. }
- W3103030515 endingPage "8617" @default.
- W3103030515 startingPage "8617" @default.
- W3103030515 abstract "Non-alcoholic fatty liver disease (NAFLD) is a complex disease that is affected by genetic predisposition and epigenetic modification. Deregulation of epigenetic pathways is now recognized as a frequent event in NAFLD, and understanding the mechanistic roles of these epigenetic factors may lead to new strategies for NAFLD treatment. Enhancer of zeste homolog 2 (EZH2) catalyzes methylation on Lys 27 of histone H3, which leads to chromatin compaction and gene silencing. EZH2 regulates embryonic development and cell lineage determination and is related to many human diseases. Recent studies show that EZH2 has critical roles in liver development, homeostasis, and regeneration. Moreover, aberrant activation of EZH2 promotes NAFLD progression. Several EZH2 inhibitors have been developed and studied both in vitro and in clinical trials. In this review, we summarize our current understanding of the role of EZH2 in NAFLD and highlight its potential as a novel therapeutic target for NAFLD treatment." @default.
- W3103030515 created "2020-11-23" @default.
- W3103030515 creator A5007426315 @default.
- W3103030515 creator A5033237694 @default.
- W3103030515 date "2020-11-16" @default.
- W3103030515 modified "2023-10-06" @default.
- W3103030515 title "EZH2 as a Potential Target for NAFLD Therapy" @default.
- W3103030515 cites W1482184499 @default.
- W3103030515 cites W1625510017 @default.
- W3103030515 cites W1829845984 @default.
- W3103030515 cites W1900105756 @default.
- W3103030515 cites W1967206613 @default.
- W3103030515 cites W1968931043 @default.
- W3103030515 cites W1970035686 @default.
- W3103030515 cites W1976235285 @default.
- W3103030515 cites W1982409009 @default.
- W3103030515 cites W1984556350 @default.
- W3103030515 cites W1990640778 @default.
- W3103030515 cites W1991327193 @default.
- W3103030515 cites W1995652213 @default.
- W3103030515 cites W1999478182 @default.
- W3103030515 cites W2001837599 @default.
- W3103030515 cites W2003597911 @default.
- W3103030515 cites W2004172747 @default.
- W3103030515 cites W2004380688 @default.
- W3103030515 cites W2008376266 @default.
- W3103030515 cites W2009036920 @default.
- W3103030515 cites W2010711123 @default.
- W3103030515 cites W2014359105 @default.
- W3103030515 cites W2015346703 @default.
- W3103030515 cites W2015811575 @default.
- W3103030515 cites W2017492512 @default.
- W3103030515 cites W2017511982 @default.
- W3103030515 cites W2025856640 @default.
- W3103030515 cites W2030509144 @default.
- W3103030515 cites W2035010201 @default.
- W3103030515 cites W2042237007 @default.
- W3103030515 cites W2046157927 @default.
- W3103030515 cites W2048964430 @default.
- W3103030515 cites W2053116646 @default.
- W3103030515 cites W2053820570 @default.
- W3103030515 cites W2054301876 @default.
- W3103030515 cites W2060597720 @default.
- W3103030515 cites W2079361407 @default.
- W3103030515 cites W2079406514 @default.
- W3103030515 cites W2079684286 @default.
- W3103030515 cites W2082579037 @default.
- W3103030515 cites W2084295010 @default.
- W3103030515 cites W2085766690 @default.
- W3103030515 cites W2091106363 @default.
- W3103030515 cites W2091296342 @default.
- W3103030515 cites W2095002834 @default.
- W3103030515 cites W2100630390 @default.
- W3103030515 cites W2101685363 @default.
- W3103030515 cites W2105154348 @default.
- W3103030515 cites W2107721366 @default.
- W3103030515 cites W2109613178 @default.
- W3103030515 cites W2111288662 @default.
- W3103030515 cites W2113056756 @default.
- W3103030515 cites W2113634596 @default.
- W3103030515 cites W2116647894 @default.
- W3103030515 cites W2118681186 @default.
- W3103030515 cites W2119304571 @default.
- W3103030515 cites W2121596297 @default.
- W3103030515 cites W2124464501 @default.
- W3103030515 cites W2132310381 @default.
- W3103030515 cites W2144178804 @default.
- W3103030515 cites W2147494386 @default.
- W3103030515 cites W2150020322 @default.
- W3103030515 cites W2160689782 @default.
- W3103030515 cites W2165820110 @default.
- W3103030515 cites W2170135815 @default.
- W3103030515 cites W2196306129 @default.
- W3103030515 cites W2210672989 @default.
- W3103030515 cites W2264682687 @default.
- W3103030515 cites W2267962525 @default.
- W3103030515 cites W2273379630 @default.
- W3103030515 cites W2322316999 @default.
- W3103030515 cites W2335838053 @default.
- W3103030515 cites W2411462408 @default.
- W3103030515 cites W2412935642 @default.
- W3103030515 cites W2416928709 @default.
- W3103030515 cites W2417502812 @default.
- W3103030515 cites W2529083585 @default.
- W3103030515 cites W2532614692 @default.
- W3103030515 cites W2567957521 @default.
- W3103030515 cites W2573090827 @default.
- W3103030515 cites W2590871167 @default.
- W3103030515 cites W2595991151 @default.
- W3103030515 cites W2602604359 @default.
- W3103030515 cites W2644084544 @default.
- W3103030515 cites W2765170429 @default.
- W3103030515 cites W2766564349 @default.
- W3103030515 cites W2767801219 @default.
- W3103030515 cites W2784041235 @default.
- W3103030515 cites W2792959572 @default.
- W3103030515 cites W2804653434 @default.
- W3103030515 cites W2805997803 @default.