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- W3103041092 abstract "Objective: To explore whether complete courses of indomethacin were necessary to close patent ductus arteriosus (PDA). Methods: Babies born 1.6 mm in diameter. With consent, they were randomly assigned before the second dose to indomethacin (to receive two more doses of indomethacin at 0.1 mg/kg irrespective of ECHO findings) or to ECHO (further doses only if PDA was >1.6 mm). Babies had serial echocardiography to day 28. Important clinical outcomes and complications of indomethacin were monitored. The primary outcome was PDA closure. Results: 74 babies were enrolled: 34 to ECHO, 40 to indomethacin. Groups were comparable at study entry. PDA closure was similar (74%). Failure of closure occurred in 10 (25%) indomethacin and nine (26%) ECHO. Reopening of the ductus arteriosus requiring a further course of indomethacin was similar, nine (23%) indomethacin versus six (18%) ECHO. One baby in the ECHO arm required a third course. Surgical ligation was similar: two (5%) indomethacin versus one (3%) ECHO. More doses of indomethacin were given to the indomethacin arm, median three (range 1–12) versus median one, (range 1–15), p Conclusion: These data suggest the selective duration of indomethacin treatment may be as effective in achieving PDA closure and offers potential for dose minimisation and reduction of adverse effects." @default.
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- W3103041092 date "2008-11-01" @default.
- W3103041092 modified "2023-09-26" @default.
- W3103041092 title "ECHOCARDIOGRAPHICALLY DIRECTED DURATION OF INDOMETHACIN TREATMENT OF THE PATENT DUCTUS ARTERIOSUS: A RANDOMISED CONTROLLED TRIAL" @default.
- W3103041092 hasPublicationYear "2008" @default.
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