Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103041540> ?p ?o ?g. }
- W3103041540 abstract "Abstract Synaptogenic mechanisms and their relevance to achieve a correct synapse density and activity in mature neurons are poorly understood. Here, we show that the tumor necrosis factor receptor-associated factor 6 (TRAF6) controls early spinogenesis by binding the cell adhesion molecule neuroplastin which is has been related to synapse formation in vivo . TRAF6-neuroplastin co-precipitations from brain samples and co-transfected HEK cells is explained by direct interaction of the proteins based on three-dimensional modelling and biochemical identification of intracellular amino acids of neuroplastin binding the TRAF-C domain of TRAF6 with micromolar affinity. TRAF6 was not only required for normal spinogenesis but also was strictly necessary to restore failed spinogenesis in neuroplastin-deficient neurons. Independently from neuroplastin’s extracellular adhesive properties or interaction with another known partner i.e. the plasma membrane Ca 2+ ATPases, TRAF6 mediated formation of new postsynapses by neuroplastin overexpression in rat hippocampal neurons. Furthermore, TRAF6-controlled spinogenesis was required for the establishment of a correct synapse density as well as proper synaptic activity and intrinsic neuronal activity as demonstrated with intracellular and extracellular electrophysiological recordings. These findings provide a novel mechanism for early synapse formation that shapes connectivity and functioning of hippocampal neurons." @default.
- W3103041540 created "2020-11-23" @default.
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- W3103041540 date "2019-09-14" @default.
- W3103041540 modified "2023-09-26" @default.
- W3103041540 title "TRAF6 controls spinogenesis instructing synapse density and neuronal activity through binding neuroplastin" @default.
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- W3103041540 cites W1827709732 @default.
- W3103041540 cites W1963700437 @default.
- W3103041540 cites W1964495361 @default.
- W3103041540 cites W1964571728 @default.
- W3103041540 cites W1965404141 @default.
- W3103041540 cites W1966207206 @default.
- W3103041540 cites W1973477546 @default.
- W3103041540 cites W1975452245 @default.
- W3103041540 cites W1977830503 @default.
- W3103041540 cites W1988011192 @default.
- W3103041540 cites W1990599804 @default.
- W3103041540 cites W1993788327 @default.
- W3103041540 cites W1994677843 @default.
- W3103041540 cites W1999744197 @default.
- W3103041540 cites W1999966549 @default.
- W3103041540 cites W2001158499 @default.
- W3103041540 cites W2001395998 @default.
- W3103041540 cites W2008869198 @default.
- W3103041540 cites W2009321212 @default.
- W3103041540 cites W2015365725 @default.
- W3103041540 cites W2024301757 @default.
- W3103041540 cites W2024815096 @default.
- W3103041540 cites W2024876935 @default.
- W3103041540 cites W2028474009 @default.
- W3103041540 cites W2031678757 @default.
- W3103041540 cites W2032972084 @default.
- W3103041540 cites W2036231188 @default.
- W3103041540 cites W2040259781 @default.
- W3103041540 cites W2043911138 @default.
- W3103041540 cites W2045363215 @default.
- W3103041540 cites W2055720472 @default.
- W3103041540 cites W2058137982 @default.
- W3103041540 cites W2058812570 @default.
- W3103041540 cites W2070732190 @default.
- W3103041540 cites W2075099242 @default.
- W3103041540 cites W2081995506 @default.
- W3103041540 cites W2082247484 @default.
- W3103041540 cites W2095065650 @default.
- W3103041540 cites W2096985729 @default.
- W3103041540 cites W2106267269 @default.
- W3103041540 cites W2117074250 @default.
- W3103041540 cites W2119421798 @default.
- W3103041540 cites W2124937181 @default.
- W3103041540 cites W2147005308 @default.
- W3103041540 cites W2147152912 @default.
- W3103041540 cites W2147816718 @default.
- W3103041540 cites W2148392040 @default.
- W3103041540 cites W2148673800 @default.
- W3103041540 cites W2149219019 @default.
- W3103041540 cites W2154043749 @default.
- W3103041540 cites W2155763709 @default.
- W3103041540 cites W2156709109 @default.
- W3103041540 cites W2159029427 @default.
- W3103041540 cites W2170349574 @default.
- W3103041540 cites W2192186565 @default.
- W3103041540 cites W2222154126 @default.
- W3103041540 cites W2317987891 @default.
- W3103041540 cites W2416170699 @default.
- W3103041540 cites W2465612254 @default.
- W3103041540 cites W2516956185 @default.
- W3103041540 cites W2604469038 @default.
- W3103041540 cites W2606715888 @default.
- W3103041540 cites W2607122245 @default.
- W3103041540 cites W2740058579 @default.
- W3103041540 cites W2742827850 @default.
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- W3103041540 cites W2766635905 @default.
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- W3103041540 doi "https://doi.org/10.1101/768341" @default.
- W3103041540 hasPublicationYear "2019" @default.
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