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• W3103044501 abstract "We study the versatile performance of networks of coupled circuits. Each of these circuits is composed of a positive and a negative feedback loop in a motif that is frequently found in genetic and neural networks. When two of these circuits are coupled with mutual repression, the system can function as a toggle switch. The variety of its states can be controlled by two parameters as we demonstrate by a detailed bifurcation analysis. In the bistable regimes, switches between the coexisting attractors can be induced by noise. When we couple larger sets of these units, we numerically observe collective coherent modes of individual fixed-point and limit-cycle behavior. It is there that the monotonic change of a single bifurcation parameter allows one to control the onset and arrest of the synchronized oscillations. This mechanism may play a role in biological applications, in particular, in connection with the segmentation clock. While tuning the bifurcation parameter, also a variety of transient patterns emerges upon approaching the stationary states, in particular, a self-organized pacemaker in a completely uniformly equipped ensemble, so that the symmetry breaking happens dynamically." @default.
• W3103044501 created "2020-11-23" @default.
• W3103044501 creator A5009660806 @default.
• W3103044501 creator A5029225056 @default.
• W3103044501 date "2014-10-28" @default.
• W3103044501 modified "2023-10-03" @default.
• W3103044501 title "Networks of coupled circuits: From a versatile toggle switch to collective coherent behavior" @default.
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• W3103044501 doi "https://doi.org/10.1063/1.4898795" @default.
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• W3103044501 hasPublicationYear "2014" @default.
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