Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103053485> ?p ?o ?g. }
- W3103053485 endingPage "12" @default.
- W3103053485 startingPage "1" @default.
- W3103053485 abstract "Tumor budding is a promising prognostic indicator in several cancers especially in colorectal cancer. However, only few studies have been conducted to assess and validate its prognostic value in laryngeal squamous cell carcinoma; none of which used pancytokeratin immunohistochemistry. In view of the modest results of treatment of laryngeal squamous cell carcinoma, the need of new prognostic indicators becomes of paramount importance. Aim of the Study. We aim to evaluate tumor budding in laryngeal squamous cell carcinoma, by haematoxylin and eosin, as well as by pancytokeratin immunohistochemistry. Material and Methods. A retrospective study on 118 cases of laryngeal squamous cell carcinoma from archives of Pathology Lab of Ain Shams University Specialized Hospital and Ain Shams University Hospitals from January 2014 to January 2017. The ENT and histopathology reports were reviewed to determine clinicopathologic data of the patients.Tumor budding shows high statistically significant relations (p = 0.0001 for each) with important clinicopathological parameters of laryngeal carcinoma (site, grade, tumor stage, lymph node stage, lymph node extracapsular invasion, and vascular invasion). The extent of tumor budding correlated with overall survival, local recurrence disease free, and distant metastasis disease free (p = 0.001 for each). Multivariate analysis showed tumor budding to be an independent prognostic factor affecting progression-free survival. There was a moderate agreement between H&E and IHC by pancytokeratin as regards detection of budding among study cases (kappa = 0.593).Tumor budding was correlated with poor prognostic clinicopathologic indicators in laryngeal squamous cell carcinoma. It is recommended to use pancytokeratin immunohistochemistry to evaluate tumor budding in laryngeal squamous cell carcinoma especially in confusing cases." @default.
- W3103053485 created "2020-11-23" @default.
- W3103053485 creator A5013232088 @default.
- W3103053485 creator A5049335756 @default.
- W3103053485 creator A5088094875 @default.
- W3103053485 date "2020-11-13" @default.
- W3103053485 modified "2023-09-28" @default.
- W3103053485 title "Evaluation of the Potential Prognostic Value of Tumor Budding in Laryngeal Carcinoma by Conventional and Immunohistochemical Staining" @default.
- W3103053485 cites W1509422232 @default.
- W3103053485 cites W1926654776 @default.
- W3103053485 cites W1983532504 @default.
- W3103053485 cites W1990575247 @default.
- W3103053485 cites W2012885850 @default.
- W3103053485 cites W2032602678 @default.
- W3103053485 cites W2043367548 @default.
- W3103053485 cites W2066146147 @default.
- W3103053485 cites W2069869793 @default.
- W3103053485 cites W2077209088 @default.
- W3103053485 cites W2092403115 @default.
- W3103053485 cites W2096428903 @default.
- W3103053485 cites W2161324764 @default.
- W3103053485 cites W2163804465 @default.
- W3103053485 cites W2175763385 @default.
- W3103053485 cites W2343363687 @default.
- W3103053485 cites W2604697564 @default.
- W3103053485 cites W2620163964 @default.
- W3103053485 cites W2773892231 @default.
- W3103053485 cites W2801334838 @default.
- W3103053485 cites W2888793802 @default.
- W3103053485 cites W2889646458 @default.
- W3103053485 cites W2898701793 @default.
- W3103053485 cites W2901387757 @default.
- W3103053485 cites W2907001126 @default.
- W3103053485 cites W2911964154 @default.
- W3103053485 cites W2921588211 @default.
- W3103053485 cites W2963492954 @default.
- W3103053485 cites W3001547747 @default.
- W3103053485 cites W3021877543 @default.
- W3103053485 cites W944953298 @default.
- W3103053485 doi "https://doi.org/10.1155/2020/9183671" @default.
- W3103053485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7683173" @default.
- W3103053485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33274177" @default.
- W3103053485 hasPublicationYear "2020" @default.
- W3103053485 type Work @default.
- W3103053485 sameAs 3103053485 @default.
- W3103053485 citedByCount "3" @default.
- W3103053485 countsByYear W31030534852022 @default.
- W3103053485 crossrefType "journal-article" @default.
- W3103053485 hasAuthorship W3103053485A5013232088 @default.
- W3103053485 hasAuthorship W3103053485A5049335756 @default.
- W3103053485 hasAuthorship W3103053485A5088094875 @default.
- W3103053485 hasBestOaLocation W31030534851 @default.
- W3103053485 hasConcept C121608353 @default.
- W3103053485 hasConcept C125473707 @default.
- W3103053485 hasConcept C126322002 @default.
- W3103053485 hasConcept C142724271 @default.
- W3103053485 hasConcept C143998085 @default.
- W3103053485 hasConcept C204232928 @default.
- W3103053485 hasConcept C2777546739 @default.
- W3103053485 hasConcept C2779013556 @default.
- W3103053485 hasConcept C2779188454 @default.
- W3103053485 hasConcept C2780849966 @default.
- W3103053485 hasConcept C2910049883 @default.
- W3103053485 hasConcept C2992571226 @default.
- W3103053485 hasConcept C544855455 @default.
- W3103053485 hasConcept C71924100 @default.
- W3103053485 hasConceptScore W3103053485C121608353 @default.
- W3103053485 hasConceptScore W3103053485C125473707 @default.
- W3103053485 hasConceptScore W3103053485C126322002 @default.
- W3103053485 hasConceptScore W3103053485C142724271 @default.
- W3103053485 hasConceptScore W3103053485C143998085 @default.
- W3103053485 hasConceptScore W3103053485C204232928 @default.
- W3103053485 hasConceptScore W3103053485C2777546739 @default.
- W3103053485 hasConceptScore W3103053485C2779013556 @default.
- W3103053485 hasConceptScore W3103053485C2779188454 @default.
- W3103053485 hasConceptScore W3103053485C2780849966 @default.
- W3103053485 hasConceptScore W3103053485C2910049883 @default.
- W3103053485 hasConceptScore W3103053485C2992571226 @default.
- W3103053485 hasConceptScore W3103053485C544855455 @default.
- W3103053485 hasConceptScore W3103053485C71924100 @default.
- W3103053485 hasLocation W31030534851 @default.
- W3103053485 hasLocation W31030534852 @default.
- W3103053485 hasOpenAccess W3103053485 @default.
- W3103053485 hasPrimaryLocation W31030534851 @default.
- W3103053485 hasRelatedWork W2000885178 @default.
- W3103053485 hasRelatedWork W2011949887 @default.
- W3103053485 hasRelatedWork W2020534317 @default.
- W3103053485 hasRelatedWork W2021173905 @default.
- W3103053485 hasRelatedWork W2161384329 @default.
- W3103053485 hasRelatedWork W2206794207 @default.
- W3103053485 hasRelatedWork W2339204668 @default.
- W3103053485 hasRelatedWork W2374404323 @default.
- W3103053485 hasRelatedWork W2472936265 @default.
- W3103053485 hasRelatedWork W3214902097 @default.
- W3103053485 hasVolume "2020" @default.
- W3103053485 isParatext "false" @default.
- W3103053485 isRetracted "false" @default.
- W3103053485 magId "3103053485" @default.