FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103072791> ?p ?o ?g. }

• W3103072791 startingPage "262410" @default.
• W3103072791 abstract "IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in autoimmune pathogenesis. We previously reported an expression quantitative trait locus (eQTL) at rs931555, 59 to IL7R, associated with stimulated monocyte IL7R mRNA expression. Unlike in T-cells, a role for IL7R in monocyte biology is poorly described. Here we detail replication and characterization of this eQTL at protein level across cell subsets and conditions in a separate cohort. We find rs6897932, a non-synonymous IL7R polymorphism associated with susceptibility to Multiple Sclerosis, Ankylosing Spondylitis and Primary Biliary Cirrhosis, is the key determinant of monocyte IL7R surface expression and soluble IL7R (sIL7R) and functions in a context-specific manner. Monocyte surface IL7R is markedly induced by LPS and TNF stimulation under the genotypic regulation of rs6897932, whereas no effect of this allele was observed on CD4+, CD8+ or CD56+ cell surface IL7R or in unstimulated monocytes. LPS-induced monocyte release of sIL7R was strongly associated with both rs6897932 genotype and expression of the splicing factor gene DDX39A. After induction of IL7R expression, human monocytes display a robust and pleiotropic transcriptional response to exogenous IL-7. Monocytes from the synovial fluid of patients with Spondyloarthritis were similarly found to express high levels of surface IL7R. These data demonstrate that disease-associated genetic variants in the IL7R gene critically impact monocyte IL7R and sIL7R expression following innate immune stimulation, suggesting a previously unappreciated key role for monocytes in IL-7 pathway biology and IL7R-associated diseases." @default.
• W3103072791 created "2020-11-23" @default.
• W3103072791 creator A5003087791 @default.
• W3103072791 creator A5005329243 @default.
• W3103072791 creator A5005477451 @default.
• W3103072791 creator A5009352007 @default.
• W3103072791 creator A5010194072 @default.
• W3103072791 creator A5012333518 @default.
• W3103072791 creator A5031330139 @default.
• W3103072791 creator A5042652724 @default.
• W3103072791 creator A5051498432 @default.
• W3103072791 creator A5057824862 @default.
• W3103072791 creator A5059194884 @default.
• W3103072791 creator A5063236767 @default.
• W3103072791 creator A5083855644 @default.
• W3103072791 creator A5087721970 @default.
• W3103072791 creator A5090516247 @default.
• W3103072791 creator A5091256958 @default.
• W3103072791 date "2018-02-08" @default.
• W3103072791 modified "2023-09-25" @default.
• W3103072791 title "The Autoimmune Disease Risk Allele rs6897932 Modulates Monocyte IL7R Surface and Soluble Receptor Levels in a Context-Specific Manner" @default.
• W3103072791 cites W1509163238 @default.
• W3103072791 cites W1558665965 @default.
• W3103072791 cites W1587026990 @default.
• W3103072791 cites W1900421196 @default.
• W3103072791 cites W1967353266 @default.
• W3103072791 cites W1975821309 @default.
• W3103072791 cites W1976351043 @default.
• W3103072791 cites W1979026253 @default.
• W3103072791 cites W1994009925 @default.
• W3103072791 cites W2012697072 @default.
• W3103072791 cites W2026853694 @default.
• W3103072791 cites W2027846315 @default.
• W3103072791 cites W2040547343 @default.
• W3103072791 cites W2069065940 @default.
• W3103072791 cites W2073109785 @default.
• W3103072791 cites W2073848442 @default.
• W3103072791 cites W2076657727 @default.
• W3103072791 cites W2089728203 @default.
• W3103072791 cites W2101280135 @default.
• W3103072791 cites W2102278945 @default.
• W3103072791 cites W2117610610 @default.
• W3103072791 cites W2134526812 @default.
• W3103072791 cites W2163013660 @default.
• W3103072791 cites W2171556560 @default.
• W3103072791 cites W2179438025 @default.
• W3103072791 cites W2388516114 @default.
• W3103072791 cites W2550031966 @default.
• W3103072791 cites W2566638801 @default.
• W3103072791 cites W2588276914 @default.
• W3103072791 cites W2601140832 @default.
• W3103072791 cites W2737809424 @default.
• W3103072791 hasPublicationYear "2018" @default.
• W3103072791 type Work @default.
• W3103072791 sameAs 3103072791 @default.
• W3103072791 citedByCount "0" @default.
• W3103072791 crossrefType "posted-content" @default.
• W3103072791 hasAuthorship W3103072791A5003087791 @default.
• W3103072791 hasAuthorship W3103072791A5005329243 @default.
• W3103072791 hasAuthorship W3103072791A5005477451 @default.
• W3103072791 hasAuthorship W3103072791A5009352007 @default.
• W3103072791 hasAuthorship W3103072791A5010194072 @default.
• W3103072791 hasAuthorship W3103072791A5012333518 @default.
• W3103072791 hasAuthorship W3103072791A5031330139 @default.
• W3103072791 hasAuthorship W3103072791A5042652724 @default.
• W3103072791 hasAuthorship W3103072791A5051498432 @default.
• W3103072791 hasAuthorship W3103072791A5057824862 @default.
• W3103072791 hasAuthorship W3103072791A5059194884 @default.
• W3103072791 hasAuthorship W3103072791A5063236767 @default.
• W3103072791 hasAuthorship W3103072791A5083855644 @default.
• W3103072791 hasAuthorship W3103072791A5087721970 @default.
• W3103072791 hasAuthorship W3103072791A5090516247 @default.
• W3103072791 hasAuthorship W3103072791A5091256958 @default.
• W3103072791 hasBestOaLocation W31030727911 @default.
• W3103072791 hasConcept C104317684 @default.
• W3103072791 hasConcept C123982805 @default.
• W3103072791 hasConcept C135763542 @default.
• W3103072791 hasConcept C151730666 @default.
• W3103072791 hasConcept C153209595 @default.
• W3103072791 hasConcept C168393362 @default.
• W3103072791 hasConcept C203014093 @default.
• W3103072791 hasConcept C2776090121 @default.
• W3103072791 hasConcept C2779343474 @default.
• W3103072791 hasConcept C2781184567 @default.
• W3103072791 hasConcept C54355233 @default.
• W3103072791 hasConcept C79484868 @default.
• W3103072791 hasConcept C86803240 @default.
• W3103072791 hasConcept C8891405 @default.
• W3103072791 hasConceptScore W3103072791C104317684 @default.
• W3103072791 hasConceptScore W3103072791C123982805 @default.
• W3103072791 hasConceptScore W3103072791C135763542 @default.
• W3103072791 hasConceptScore W3103072791C151730666 @default.
• W3103072791 hasConceptScore W3103072791C153209595 @default.
• W3103072791 hasConceptScore W3103072791C168393362 @default.
• W3103072791 hasConceptScore W3103072791C203014093 @default.
• W3103072791 hasConceptScore W3103072791C2776090121 @default.
• W3103072791 hasConceptScore W3103072791C2779343474 @default.
• W3103072791 hasConceptScore W3103072791C2781184567 @default.
• W3103072791 hasConceptScore W3103072791C54355233 @default.

• next