Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103106384> ?p ?o ?g. }
- W3103106384 abstract "Summary Despite evidence that helminths protect from metabolic disease, a major gap exists in understanding the underlying mechanism(s). Here we demonstrate that bone marrow derived macrophages (BMDM) from S. mansoni infected male ApoE -/- mice have dramatically increased mitochondrial respiration compared to those from uninfected mice. This change associates with increased glucose and palmitate shuttling into TCA cycle intermediates and decreased accumulation of cellular cholesterol esters. Moreover, systemic metabolic modulation by schistosomes is a function of biological sex, where infection protects ApoE -/- male, but not female, mice from obesity and glucose intolerance. Sex-dependence extends to myeloid cells, where reprogramming leads to opposite cholesterol phenotypes in BMDM from females and males. Finally, the metabolic reprogramming of male myeloid cells is transferrable via bone marrow transplantation to an uninfected host, indicating maintenance of reprogramming in the absence of sustained antigen exposure. This work reveals that S. mansoni systemic reprograming of myeloid metabolism is sex-dependent." @default.
- W3103106384 created "2020-11-23" @default.
- W3103106384 creator A5017294911 @default.
- W3103106384 creator A5034713503 @default.
- W3103106384 creator A5041902526 @default.
- W3103106384 creator A5042866760 @default.
- W3103106384 creator A5043480262 @default.
- W3103106384 creator A5052704150 @default.
- W3103106384 creator A5057351324 @default.
- W3103106384 creator A5059311673 @default.
- W3103106384 date "2020-04-20" @default.
- W3103106384 modified "2023-10-18" @default.
- W3103106384 title "Schistosoma mansoni infection reprograms the metabolic potential of the myeloid lineage in a mouse model of metabolic syndrome" @default.
- W3103106384 cites W106107227 @default.
- W3103106384 cites W1570155932 @default.
- W3103106384 cites W1838882977 @default.
- W3103106384 cites W1976714959 @default.
- W3103106384 cites W1977334706 @default.
- W3103106384 cites W1988128973 @default.
- W3103106384 cites W1989090840 @default.
- W3103106384 cites W1990716354 @default.
- W3103106384 cites W1992246862 @default.
- W3103106384 cites W1996020742 @default.
- W3103106384 cites W2002215164 @default.
- W3103106384 cites W2002910405 @default.
- W3103106384 cites W2041512582 @default.
- W3103106384 cites W2044747531 @default.
- W3103106384 cites W2045333877 @default.
- W3103106384 cites W2052554962 @default.
- W3103106384 cites W2064890454 @default.
- W3103106384 cites W2067031028 @default.
- W3103106384 cites W2070908474 @default.
- W3103106384 cites W2071022240 @default.
- W3103106384 cites W2073146140 @default.
- W3103106384 cites W2079426770 @default.
- W3103106384 cites W2083183631 @default.
- W3103106384 cites W2091977386 @default.
- W3103106384 cites W2092205926 @default.
- W3103106384 cites W2109307504 @default.
- W3103106384 cites W2114104545 @default.
- W3103106384 cites W2114749317 @default.
- W3103106384 cites W2122825543 @default.
- W3103106384 cites W2127974745 @default.
- W3103106384 cites W2127992998 @default.
- W3103106384 cites W2130116522 @default.
- W3103106384 cites W2133233871 @default.
- W3103106384 cites W2135272175 @default.
- W3103106384 cites W2138207763 @default.
- W3103106384 cites W2138257090 @default.
- W3103106384 cites W2139754172 @default.
- W3103106384 cites W2141914388 @default.
- W3103106384 cites W2147663252 @default.
- W3103106384 cites W2149053203 @default.
- W3103106384 cites W2153433640 @default.
- W3103106384 cites W2154252538 @default.
- W3103106384 cites W2160378233 @default.
- W3103106384 cites W2162778138 @default.
- W3103106384 cites W2165280863 @default.
- W3103106384 cites W2166118660 @default.
- W3103106384 cites W2167376541 @default.
- W3103106384 cites W2168930514 @default.
- W3103106384 cites W2169456326 @default.
- W3103106384 cites W2262354804 @default.
- W3103106384 cites W2328618013 @default.
- W3103106384 cites W2331305984 @default.
- W3103106384 cites W2342126943 @default.
- W3103106384 cites W2394857857 @default.
- W3103106384 cites W2414200861 @default.
- W3103106384 cites W2432815617 @default.
- W3103106384 cites W2463549330 @default.
- W3103106384 cites W2472865244 @default.
- W3103106384 cites W2498337161 @default.
- W3103106384 cites W2582090837 @default.
- W3103106384 cites W2592585942 @default.
- W3103106384 cites W2605837333 @default.
- W3103106384 cites W2614578122 @default.
- W3103106384 cites W2724395578 @default.
- W3103106384 cites W2735344772 @default.
- W3103106384 cites W2743657096 @default.
- W3103106384 cites W2767099852 @default.
- W3103106384 cites W2768908212 @default.
- W3103106384 cites W2783329544 @default.
- W3103106384 cites W2783711120 @default.
- W3103106384 cites W2788772427 @default.
- W3103106384 cites W2789525474 @default.
- W3103106384 cites W2789885586 @default.
- W3103106384 cites W2802636975 @default.
- W3103106384 cites W2807532357 @default.
- W3103106384 cites W2884762454 @default.
- W3103106384 cites W2888686134 @default.
- W3103106384 cites W2888901214 @default.
- W3103106384 cites W2892214804 @default.
- W3103106384 cites W2901419793 @default.
- W3103106384 cites W2902322680 @default.
- W3103106384 cites W2936361906 @default.
- W3103106384 cites W2944563907 @default.
- W3103106384 cites W2945274410 @default.
- W3103106384 cites W2945702356 @default.
- W3103106384 cites W4255455317 @default.
- W3103106384 cites W854589012 @default.