FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103166073> ?p ?o ?g. }

• W3103166073 endingPage "106343" @default.
• W3103166073 startingPage "106343" @default.
• W3103166073 abstract "As is known to all, co-solvency or solvent mixing is the most common and easy-to-use method in the pharmaceutical industry for the improvement of solubility of poorly soluble drugs. The aim of this investigation was to determine the solubility data of pazopanib in (ethyl acetate + ethanol) and (ethyl acetate + 2-propanol) binary mixture solvents at various temperatures ranging from 288.15 K to 328.15 K, and correlated by Jouyban-acree model and Apelblat-Jouyban-Acree model. The results showed that solubility of pazopanib increased with the increasing temperature, and the co-solvency phenomenon was occurred in the dissolution process of pazopanib in two mixed solvents. The maximum solubility value appeared at w = 0.60 (the mass fraction of ethyl acetate in mixed solvents systems). At 288.15 K, solubility was increased by 4.37 and 3.94 times. The correlation results show that the maximum values of RAD and RMSD are no more than 5.13% and 3.37 × 10−6, respectively. The thermodynamic models can all correlate the solubility behaviour of pazopanib in pure and mixed solvents mixtures well. In addition, from the solvent effect results, nonspecific dipolarity/polarizability interactions are favorable to dissolution, and the nonspecific dipolarity/polarizability interactions had a great contribution to dissolution. Moreover, apparent thermodynamic quantities of pazopanib dissolution process in the ethyl acetate + ethanol/2-propanol mixtures, including entropy, enthalpy and Gibbs energy were computed using van't Hoff and Gibbs equations. The results of apparent dissolution properties are all positive which indicate the dissolution of pazopanib in two mixed solvents is an endothermic and entropy-increasing process and the enthalpy is the main contributor to standard Gibbs energy of solution process in all compositions. The discovery of co-solvency phenomenon is important to optimize the purification and improve bioavailability of pazopanib, and the solvent mixing is a common, easy-to-use and effective method to improve the solubility of pazopanib." @default.
• W3103166073 created "2020-11-23" @default.
• W3103166073 creator A5014371843 @default.
• W3103166073 creator A5026394330 @default.
• W3103166073 creator A5046078938 @default.
• W3103166073 creator A5050804075 @default.
• W3103166073 creator A5052647506 @default.
• W3103166073 creator A5061925963 @default.
• W3103166073 date "2021-04-01" @default.
• W3103166073 modified "2023-10-11" @default.
• W3103166073 title "Solubility enhancement, solvent effect and thermodynamic analysis of pazopanib in co-solvent mixtures" @default.
• W3103166073 cites W1573363574 @default.
• W3103166073 cites W1600161348 @default.
• W3103166073 cites W1968016399 @default.
• W3103166073 cites W1983819655 @default.
• W3103166073 cites W2007041119 @default.
• W3103166073 cites W2007545333 @default.
• W3103166073 cites W2035053532 @default.
• W3103166073 cites W2060482516 @default.
• W3103166073 cites W2072476365 @default.
• W3103166073 cites W2074678995 @default.
• W3103166073 cites W2094961283 @default.
• W3103166073 cites W2099022883 @default.
• W3103166073 cites W2111147673 @default.
• W3103166073 cites W2121237369 @default.
• W3103166073 cites W2569314360 @default.
• W3103166073 cites W2745788092 @default.
• W3103166073 cites W2760613511 @default.
• W3103166073 cites W2913234455 @default.
• W3103166073 cites W2931215585 @default.
• W3103166073 cites W2951050136 @default.
• W3103166073 cites W2991364274 @default.
• W3103166073 cites W2992360811 @default.
• W3103166073 cites W3004261297 @default.
• W3103166073 cites W4247618793 @default.
• W3103166073 cites W4384816539 @default.
• W3103166073 doi "https://doi.org/10.1016/j.jct.2020.106343" @default.
• W3103166073 hasPublicationYear "2021" @default.
• W3103166073 type Work @default.
• W3103166073 sameAs 3103166073 @default.
• W3103166073 citedByCount "12" @default.
• W3103166073 countsByYear W31031660732021 @default.
• W3103166073 countsByYear W31031660732022 @default.
• W3103166073 countsByYear W31031660732023 @default.
• W3103166073 crossrefType "journal-article" @default.
• W3103166073 hasAuthorship W3103166073A5014371843 @default.
• W3103166073 hasAuthorship W3103166073A5026394330 @default.
• W3103166073 hasAuthorship W3103166073A5046078938 @default.
• W3103166073 hasAuthorship W3103166073A5050804075 @default.
• W3103166073 hasAuthorship W3103166073A5052647506 @default.
• W3103166073 hasAuthorship W3103166073A5061925963 @default.
• W3103166073 hasConcept C121332964 @default.
• W3103166073 hasConcept C143998085 @default.
• W3103166073 hasConcept C146477669 @default.
• W3103166073 hasConcept C155574463 @default.
• W3103166073 hasConcept C178790620 @default.
• W3103166073 hasConcept C185592680 @default.
• W3103166073 hasConcept C2777472916 @default.
• W3103166073 hasConcept C2778439243 @default.
• W3103166073 hasConcept C2779490328 @default.
• W3103166073 hasConcept C2779858419 @default.
• W3103166073 hasConcept C2780471494 @default.
• W3103166073 hasConcept C3288061 @default.
• W3103166073 hasConcept C43617362 @default.
• W3103166073 hasConcept C71924100 @default.
• W3103166073 hasConcept C88380143 @default.
• W3103166073 hasConcept C97355855 @default.
• W3103166073 hasConceptScore W3103166073C121332964 @default.
• W3103166073 hasConceptScore W3103166073C143998085 @default.
• W3103166073 hasConceptScore W3103166073C146477669 @default.
• W3103166073 hasConceptScore W3103166073C155574463 @default.
• W3103166073 hasConceptScore W3103166073C178790620 @default.
• W3103166073 hasConceptScore W3103166073C185592680 @default.
• W3103166073 hasConceptScore W3103166073C2777472916 @default.
• W3103166073 hasConceptScore W3103166073C2778439243 @default.
• W3103166073 hasConceptScore W3103166073C2779490328 @default.
• W3103166073 hasConceptScore W3103166073C2779858419 @default.
• W3103166073 hasConceptScore W3103166073C2780471494 @default.
• W3103166073 hasConceptScore W3103166073C3288061 @default.
• W3103166073 hasConceptScore W3103166073C43617362 @default.
• W3103166073 hasConceptScore W3103166073C71924100 @default.
• W3103166073 hasConceptScore W3103166073C88380143 @default.
• W3103166073 hasConceptScore W3103166073C97355855 @default.
• W3103166073 hasLocation W31031660731 @default.
• W3103166073 hasOpenAccess W3103166073 @default.
• W3103166073 hasPrimaryLocation W31031660731 @default.
• W3103166073 hasRelatedWork W1595022488 @default.
• W3103166073 hasRelatedWork W1988863621 @default.
• W3103166073 hasRelatedWork W2026995444 @default.
• W3103166073 hasRelatedWork W2348400056 @default.
• W3103166073 hasRelatedWork W2363151802 @default.
• W3103166073 hasRelatedWork W2369157176 @default.
• W3103166073 hasRelatedWork W2369175295 @default.
• W3103166073 hasRelatedWork W2373625723 @default.
• W3103166073 hasRelatedWork W2383548838 @default.
• W3103166073 hasRelatedWork W4361028552 @default.
• W3103166073 hasVolume "155" @default.
• W3103166073 isParatext "false" @default.

• next