Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103174571> ?p ?o ?g. }
- W3103174571 abstract "Abstract Dysbiotic microbiomes are linked to many pathological outcomes including different metabolic disorders like diabetes, atherosclerosis and even cancer. Breast cancer is the second leading cause of cancer associated death in women, and triple negative breast cancer (TNBC) is the most aggressive type with major challenges for intervention. Previous reports suggested that Parapoxvirus signatures are one of the predominant dysbiotic viral signatures in TNBC. These viruses encode several genes that are homologs of human genes. In this study, we show that the VEGF homolog encoded by Parapoxviruses, can induce cell proliferation, and alter metabolism of breast cancer and normal breast cells, through alteration of MAPK-ERK and PI3K-AKT signaling. In addition, the activity of the transcription factor FoxO1 was altered by viral-encoded VEGF through activation of the PI3K-AKT pathway, leading to reprogramming of cellular metabolic gene expression. Therefore, this study provides new insights into the function of viral-encoded VEGFs, which promoted the growth of the breast cancer cells and imparted proliferative phenotype with altered metabolism in normal breast cells." @default.
- W3103174571 created "2020-11-23" @default.
- W3103174571 creator A5020250345 @default.
- W3103174571 creator A5032066345 @default.
- W3103174571 creator A5033041410 @default.
- W3103174571 creator A5033540756 @default.
- W3103174571 creator A5059292633 @default.
- W3103174571 date "2020-11-20" @default.
- W3103174571 modified "2023-10-10" @default.
- W3103174571 title "Vascular endothelial growth factor encoded by Parapoxviruses can regulate metabolism and survival of triple negative breast cancer cells" @default.
- W3103174571 cites W1582316077 @default.
- W3103174571 cites W1583767403 @default.
- W3103174571 cites W1591430481 @default.
- W3103174571 cites W1678994007 @default.
- W3103174571 cites W1736545692 @default.
- W3103174571 cites W1804718109 @default.
- W3103174571 cites W1829383288 @default.
- W3103174571 cites W1978139115 @default.
- W3103174571 cites W1980568044 @default.
- W3103174571 cites W1983064145 @default.
- W3103174571 cites W1986234170 @default.
- W3103174571 cites W1988137543 @default.
- W3103174571 cites W2002225614 @default.
- W3103174571 cites W2017021142 @default.
- W3103174571 cites W2018715097 @default.
- W3103174571 cites W2026885757 @default.
- W3103174571 cites W2030369058 @default.
- W3103174571 cites W2031540681 @default.
- W3103174571 cites W2032040083 @default.
- W3103174571 cites W2034201098 @default.
- W3103174571 cites W2037872708 @default.
- W3103174571 cites W2060592426 @default.
- W3103174571 cites W2062289724 @default.
- W3103174571 cites W2069717224 @default.
- W3103174571 cites W2072009397 @default.
- W3103174571 cites W2073045469 @default.
- W3103174571 cites W2073924079 @default.
- W3103174571 cites W2075832262 @default.
- W3103174571 cites W2076103389 @default.
- W3103174571 cites W2088209062 @default.
- W3103174571 cites W2099192257 @default.
- W3103174571 cites W2101899879 @default.
- W3103174571 cites W2109639997 @default.
- W3103174571 cites W2121720480 @default.
- W3103174571 cites W2129898733 @default.
- W3103174571 cites W2130998671 @default.
- W3103174571 cites W2131659746 @default.
- W3103174571 cites W2138787512 @default.
- W3103174571 cites W2140642422 @default.
- W3103174571 cites W2142739240 @default.
- W3103174571 cites W2158316748 @default.
- W3103174571 cites W2168133196 @default.
- W3103174571 cites W2181693984 @default.
- W3103174571 cites W2192708678 @default.
- W3103174571 cites W2210268838 @default.
- W3103174571 cites W2234115940 @default.
- W3103174571 cites W2273316674 @default.
- W3103174571 cites W2323331306 @default.
- W3103174571 cites W2337372962 @default.
- W3103174571 cites W2388163742 @default.
- W3103174571 cites W2395626624 @default.
- W3103174571 cites W2401225309 @default.
- W3103174571 cites W2408483783 @default.
- W3103174571 cites W2503851771 @default.
- W3103174571 cites W2508551534 @default.
- W3103174571 cites W2510435007 @default.
- W3103174571 cites W2546610174 @default.
- W3103174571 cites W2577439289 @default.
- W3103174571 cites W2612772400 @default.
- W3103174571 cites W2717369771 @default.
- W3103174571 cites W2749187924 @default.
- W3103174571 cites W2759449520 @default.
- W3103174571 cites W2795063553 @default.
- W3103174571 cites W2795908250 @default.
- W3103174571 cites W2800586930 @default.
- W3103174571 cites W2801011555 @default.
- W3103174571 cites W2885029979 @default.
- W3103174571 cites W2885273732 @default.
- W3103174571 cites W2886247440 @default.
- W3103174571 cites W2902532424 @default.
- W3103174571 cites W2905324652 @default.
- W3103174571 cites W2905965925 @default.
- W3103174571 cites W2911915561 @default.
- W3103174571 cites W2913455564 @default.
- W3103174571 cites W2916683250 @default.
- W3103174571 cites W2947874219 @default.
- W3103174571 cites W2952564192 @default.
- W3103174571 cites W2970913246 @default.
- W3103174571 doi "https://doi.org/10.1038/s41419-020-03203-4" @default.
- W3103174571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7679371" @default.
- W3103174571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33219203" @default.
- W3103174571 hasPublicationYear "2020" @default.
- W3103174571 type Work @default.
- W3103174571 sameAs 3103174571 @default.
- W3103174571 citedByCount "3" @default.
- W3103174571 countsByYear W31031745712021 @default.
- W3103174571 countsByYear W31031745712023 @default.
- W3103174571 crossrefType "journal-article" @default.
- W3103174571 hasAuthorship W3103174571A5020250345 @default.
- W3103174571 hasAuthorship W3103174571A5032066345 @default.