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- W3103226569 endingPage "5317" @default.
- W3103226569 startingPage "5317" @default.
- W3103226569 abstract "Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination required to activate a PS imparts a certain amount of selectivity to PDT treatments, poor tumor accumulation and cell internalization are still inherent properties of most intravenously administered PSs. As a result, common consequences of PDT include skin photosensitivity. To overcome the mentioned issues, PSs may be tailored to specifically target overexpressed biomarkers of tumors. This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment. Alternatively, PSs may be incorporated into ligand-targeted nanocarriers, which may also encompass multi-functionalities, including diagnosis and therapy. In this review, we highlight the major advances in active targeting of PSs, either by means of ligand-derived bioconjugates or by exploiting ligand-targeting nanocarriers." @default.
- W3103226569 created "2020-11-23" @default.
- W3103226569 creator A5000876157 @default.
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- W3103226569 creator A5059647159 @default.
- W3103226569 creator A5070495189 @default.
- W3103226569 creator A5088910380 @default.
- W3103226569 date "2020-11-14" @default.
- W3103226569 modified "2023-10-16" @default.
- W3103226569 title "Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment" @default.
- W3103226569 cites W1043643217 @default.
- W3103226569 cites W1420516430 @default.
- W3103226569 cites W1520425169 @default.
- W3103226569 cites W1555561146 @default.
- W3103226569 cites W1560819517 @default.
- W3103226569 cites W1820203959 @default.
- W3103226569 cites W1829321784 @default.
- W3103226569 cites W1869957540 @default.
- W3103226569 cites W1909548258 @default.
- W3103226569 cites W1963946540 @default.
- W3103226569 cites W1965872874 @default.
- W3103226569 cites W1967851963 @default.
- W3103226569 cites W1967970901 @default.
- W3103226569 cites W1968627984 @default.
- W3103226569 cites W1968718987 @default.
- W3103226569 cites W1968858321 @default.
- W3103226569 cites W1970707765 @default.
- W3103226569 cites W1973008689 @default.
- W3103226569 cites W1978225297 @default.
- W3103226569 cites W1978244778 @default.
- W3103226569 cites W1979493201 @default.
- W3103226569 cites W1979740446 @default.
- W3103226569 cites W1980414616 @default.
- W3103226569 cites W1983150753 @default.
- W3103226569 cites W1983692618 @default.
- W3103226569 cites W1984007340 @default.
- W3103226569 cites W1984076071 @default.
- W3103226569 cites W1985851739 @default.
- W3103226569 cites W1987433127 @default.
- W3103226569 cites W1989658253 @default.
- W3103226569 cites W1990455420 @default.
- W3103226569 cites W1992913621 @default.
- W3103226569 cites W1996497248 @default.
- W3103226569 cites W1998162097 @default.
- W3103226569 cites W2000241906 @default.
- W3103226569 cites W2000678460 @default.
- W3103226569 cites W2001498530 @default.
- W3103226569 cites W2001921621 @default.
- W3103226569 cites W2003993864 @default.
- W3103226569 cites W2006792020 @default.
- W3103226569 cites W2014378246 @default.
- W3103226569 cites W2015269201 @default.
- W3103226569 cites W2016095013 @default.
- W3103226569 cites W2018218848 @default.
- W3103226569 cites W2018433754 @default.
- W3103226569 cites W2018762019 @default.
- W3103226569 cites W2023427658 @default.
- W3103226569 cites W2023721332 @default.
- W3103226569 cites W2026797451 @default.
- W3103226569 cites W2027437657 @default.
- W3103226569 cites W2028282828 @default.
- W3103226569 cites W2030348219 @default.
- W3103226569 cites W2032761922 @default.
- W3103226569 cites W2032875036 @default.
- W3103226569 cites W2033278321 @default.
- W3103226569 cites W2033281188 @default.
- W3103226569 cites W2034854030 @default.
- W3103226569 cites W2035342960 @default.
- W3103226569 cites W2036096376 @default.
- W3103226569 cites W2037075525 @default.
- W3103226569 cites W2037621047 @default.
- W3103226569 cites W2041357241 @default.
- W3103226569 cites W2041759339 @default.
- W3103226569 cites W2043746859 @default.
- W3103226569 cites W2045009064 @default.
- W3103226569 cites W2046192326 @default.
- W3103226569 cites W2046866645 @default.
- W3103226569 cites W2048313558 @default.
- W3103226569 cites W2049581270 @default.
- W3103226569 cites W2050499474 @default.
- W3103226569 cites W2051761966 @default.
- W3103226569 cites W2052006907 @default.
- W3103226569 cites W2054751903 @default.
- W3103226569 cites W2058369946 @default.
- W3103226569 cites W2061510929 @default.
- W3103226569 cites W2064509637 @default.
- W3103226569 cites W2065819916 @default.
- W3103226569 cites W2068545964 @default.
- W3103226569 cites W2070360032 @default.
- W3103226569 cites W2070529511 @default.
- W3103226569 cites W2071069813 @default.
- W3103226569 cites W2072210671 @default.
- W3103226569 cites W2073662815 @default.
- W3103226569 cites W2074739302 @default.
- W3103226569 cites W2075476646 @default.
- W3103226569 cites W2076226743 @default.
- W3103226569 cites W2078937040 @default.