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- W3103268846 endingPage "1161" @default.
- W3103268846 startingPage "1144" @default.
- W3103268846 abstract "The ubiquitin-proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in various cancers. Since Bortezomib, a proteasome inhibitor, received FDA approval for the treatment of multiple myeloma and mantle cell lymphoma, increasing numbers of researchers have been seeking drugs targeting the UPS as a cancer therapeutic strategy. Here, we introduce the essential component of UPS, including ubiquitinating enzymes, deubiquitinating enzymes and 26S proteasome, and we summarize their targets and mechanisms that are crucial for tumorigenesis. In addition, we briefly discuss some UPS inhibitors, which are currently in clinical trials as cancer therapeutics." @default.
- W3103268846 created "2020-11-23" @default.
- W3103268846 creator A5000172274 @default.
- W3103268846 creator A5067945024 @default.
- W3103268846 creator A5068799024 @default.
- W3103268846 date "2020-11-01" @default.
- W3103268846 modified "2023-10-17" @default.
- W3103268846 title "Ubiquitin–proteasome system (UPS) as a target for anticancer treatment" @default.
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