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- W3103280441 endingPage "026023" @default.
- W3103280441 startingPage "026023" @default.
- W3103280441 abstract "Emerging evidence shows that cognitive deficits in Alzheimer disease (AD) are associated with disruptions in brain functional connectivity. Thus, the identification of alterations in AD functional networks has become a topic of increasing interest. However, to what extent AD induces disruption of the balance of local and global information processing in the human brain remains elusive. The main objective of this study is to explore the dynamic topological changes of AD networks in terms of brain network segregation and integration. We used electroencephalography (EEG) data recorded from 20 participants (10 AD patients and 10 healthy controls) during resting state. Functional brain networks were reconstructed using EEG source connectivity computed in different frequency bands. Graph theoretical analyses were performed assess differences between both groups. Results revealed that AD networks, compared to networks of age matched healthy controls, are characterized by lower global information processing (integration) and higher local information processing (segregation). Results showed also significant correlation between the alterations in the AD patients functional brain networks and their cognitive scores. These findings may contribute to the development of EEG network-based test that could strengthen results obtained from currently used neurophysiological tests in neurodegenerative diseases." @default.
- W3103280441 created "2020-11-23" @default.
- W3103280441 creator A5032339285 @default.
- W3103280441 creator A5086139129 @default.
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- W3103280441 creator A5088812873 @default.
- W3103280441 creator A5089530844 @default.
- W3103280441 creator A5091227060 @default.
- W3103280441 date "2018-02-16" @default.
- W3103280441 modified "2023-10-14" @default.
- W3103280441 title "Reduced integration and improved segregation of functional brain networks in Alzheimer’s disease" @default.
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