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• W3103297183 endingPage "025004" @default.
• W3103297183 startingPage "025004" @default.
• W3103297183 abstract "Bacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences, called 'spacers' into its CRISPR system. Spacers in the CRISPR system provide a record of the history of bacteria and phage coevolution. We use a physical model to study the dynamics of this coevolution as it evolves stochastically over time. We focus on the impact of mutation and recombination on bacteria and phage evolution and evasion. We discuss the effect of different spacer deletion mechanisms on the coevolutionary dynamics. We make predictions about bacteria and phage population growth, spacer diversity within the CRISPR locus, and spacer protection against the phage population." @default.
• W3103297183 created "2020-11-23" @default.
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• W3103297183 date "2013-03-15" @default.
• W3103297183 modified "2023-10-16" @default.
• W3103297183 title "Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system" @default.
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• W3103297183 doi "https://doi.org/10.1088/1478-3975/10/2/025004" @default.
• W3103297183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23492852" @default.
• W3103297183 hasPublicationYear "2013" @default.
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