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- W3103323009 endingPage "8758" @default.
- W3103323009 startingPage "8758" @default.
- W3103323009 abstract "In the mammalian cochlea, specialized ribbon-type synapses between sensory inner hair cells (IHCs) and postsynaptic spiral ganglion neurons ensure the temporal precision and indefatigability of synaptic sound encoding. These high-through-put synapses are presynaptically characterized by an electron-dense projection—the synaptic ribbon—which provides structural scaffolding and tethers a large pool of synaptic vesicles. While advances have been made in recent years in deciphering the molecular anatomy and function of these specialized active zones, the developmental assembly of this presynaptic interaction hub remains largely elusive. In this review, we discuss the dynamic nature of IHC (pre-) synaptogenesis and highlight molecular key players as well as the transport pathways underlying this process. Since developmental assembly appears to be a highly dynamic process, we further ask if this structural plasticity might be maintained into adulthood, how this may influence the functional properties of a given IHC synapse and how such plasticity could be regulated on the molecular level. To do so, we take a closer look at other ribbon-bearing systems, such as retinal photoreceptors and pinealocytes and aim to infer conserved mechanisms that may mediate these phenomena." @default.
- W3103323009 created "2020-11-23" @default.
- W3103323009 creator A5050056813 @default.
- W3103323009 creator A5055065688 @default.
- W3103323009 date "2020-11-19" @default.
- W3103323009 modified "2023-10-18" @default.
- W3103323009 title "Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses—A Presynaptic Perspective" @default.
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