FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103346883> ?p ?o ?g. }

• W3103346883 abstract "Abstract Background Environmental enteropathy is an example of a poorly-understood intestinal disorder affecting millions of children worldwide, characterized by malabsorption and stunting. Although there is increasing interest in non-invasive means of assessing intestinal structure and function, the potential value of intestinal biopsy for histology, immunostaining, RNA sequencing and epigenetic work means that endoscopic biopsy remains extremely valuable. We here report our experience in the BEECH (Biomarkers of Environmental Enteropathy in CHildren) study of stunting in Zambia, in the belief that it may help address the knowledge gap regarding the safety of endoscopic biopsy in vulnerable young children. Methods We report our experience of safety in 119 children undergoing endoscopic biopsy in the BEECH study in Lusaka Children’s Hospital, Lusaka, and discuss ethical considerations in this light. Results Upper gastrointestinal endoscopy was performed on children with stunting (length-for-age z score -2 or less) not responsive to nutritional interventions. Conscious sedation was provided by anaesthetists. Of 119 children, 5 (4%) developed transient desaturation, but no serious adverse events were experienced; no clinical, demographic or anaesthetic characteristics were identified as predictive of desaturation. Two children derived clinically useful information from the endoscopy, one life-saving. Of 105 lactase tests, 59 (54%) showed hypolactasia. Discussion Children with stunting underwent endoscopy safely, and some derived clinical benefit. Safety and the possibility of clinical benefit are usually felt to be preconditions for the ethical justification for endoscopy for research in children, and we believe that these conditions were met in this study." @default.
• W3103346883 created "2020-11-23" @default.
• W3103346883 creator A5004331135 @default.
• W3103346883 creator A5026531925 @default.
• W3103346883 creator A5026804618 @default.
• W3103346883 creator A5029489919 @default.
• W3103346883 creator A5041565011 @default.
• W3103346883 date "2020-11-14" @default.
• W3103346883 modified "2023-09-28" @default.
• W3103346883 title "Safety and Ethics in Endoscopic Studies in Children: Evidence From the BEECH Study in Zambia" @default.
• W3103346883 cites W1493949982 @default.
• W3103346883 cites W1528540080 @default.
• W3103346883 cites W1577149967 @default.
• W3103346883 cites W1873356126 @default.
• W3103346883 cites W1969897424 @default.
• W3103346883 cites W1974200634 @default.
• W3103346883 cites W1988331683 @default.
• W3103346883 cites W1999878521 @default.
• W3103346883 cites W2001712128 @default.
• W3103346883 cites W2014521622 @default.
• W3103346883 cites W2024244973 @default.
• W3103346883 cites W2034847662 @default.
• W3103346883 cites W2053684368 @default.
• W3103346883 cites W2085625204 @default.
• W3103346883 cites W2094729662 @default.
• W3103346883 cites W2098510362 @default.
• W3103346883 cites W2126858817 @default.
• W3103346883 cites W2127081272 @default.
• W3103346883 cites W2128251374 @default.
• W3103346883 cites W2161643046 @default.
• W3103346883 cites W2163685399 @default.
• W3103346883 cites W2172611160 @default.
• W3103346883 cites W2289723459 @default.
• W3103346883 cites W2313882467 @default.
• W3103346883 cites W2321000299 @default.
• W3103346883 cites W2323121212 @default.
• W3103346883 cites W2339382213 @default.
• W3103346883 cites W2340497728 @default.
• W3103346883 cites W2401598834 @default.
• W3103346883 cites W2416443865 @default.
• W3103346883 cites W2471702052 @default.
• W3103346883 cites W2619844222 @default.
• W3103346883 cites W2737322495 @default.
• W3103346883 cites W2742657997 @default.
• W3103346883 cites W2776301743 @default.
• W3103346883 cites W2783115868 @default.
• W3103346883 cites W2785371307 @default.
• W3103346883 cites W2788364872 @default.
• W3103346883 cites W2808874006 @default.
• W3103346883 cites W2830919336 @default.
• W3103346883 cites W2903935951 @default.
• W3103346883 cites W3193067838 @default.
• W3103346883 cites W4239240204 @default.
• W3103346883 cites W4320300927 @default.
• W3103346883 doi "https://doi.org/10.1093/tropej/fmaa074" @default.
• W3103346883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7948385" @default.
• W3103346883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33188430" @default.
• W3103346883 hasPublicationYear "2020" @default.
• W3103346883 type Work @default.
• W3103346883 sameAs 3103346883 @default.
• W3103346883 citedByCount "7" @default.
• W3103346883 countsByYear W31033468832021 @default.
• W3103346883 countsByYear W31033468832022 @default.
• W3103346883 countsByYear W31033468832023 @default.
• W3103346883 crossrefType "journal-article" @default.
• W3103346883 hasAuthorship W3103346883A5004331135 @default.
• W3103346883 hasAuthorship W3103346883A5026531925 @default.
• W3103346883 hasAuthorship W3103346883A5026804618 @default.
• W3103346883 hasAuthorship W3103346883A5029489919 @default.
• W3103346883 hasAuthorship W3103346883A5041565011 @default.
• W3103346883 hasBestOaLocation W31033468831 @default.
• W3103346883 hasConcept C126322002 @default.
• W3103346883 hasConcept C141071460 @default.
• W3103346883 hasConcept C142724271 @default.
• W3103346883 hasConcept C187212893 @default.
• W3103346883 hasConcept C2775934546 @default.
• W3103346883 hasConcept C2776814716 @default.
• W3103346883 hasConcept C2778451229 @default.
• W3103346883 hasConcept C2780439177 @default.
• W3103346883 hasConcept C71924100 @default.
• W3103346883 hasConceptScore W3103346883C126322002 @default.
• W3103346883 hasConceptScore W3103346883C141071460 @default.
• W3103346883 hasConceptScore W3103346883C142724271 @default.
• W3103346883 hasConceptScore W3103346883C187212893 @default.
• W3103346883 hasConceptScore W3103346883C2775934546 @default.
• W3103346883 hasConceptScore W3103346883C2776814716 @default.
• W3103346883 hasConceptScore W3103346883C2778451229 @default.
• W3103346883 hasConceptScore W3103346883C2780439177 @default.
• W3103346883 hasConceptScore W3103346883C71924100 @default.
• W3103346883 hasFunder F4320306137 @default.
• W3103346883 hasIssue "1" @default.
• W3103346883 hasLocation W31033468831 @default.
• W3103346883 hasLocation W31033468832 @default.
• W3103346883 hasOpenAccess W3103346883 @default.
• W3103346883 hasPrimaryLocation W31033468831 @default.
• W3103346883 hasRelatedWork W181730864 @default.
• W3103346883 hasRelatedWork W1989647168 @default.
• W3103346883 hasRelatedWork W2004133282 @default.
• W3103346883 hasRelatedWork W2006218228 @default.
• W3103346883 hasRelatedWork W2038126057 @default.

• next