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- W3103358366 abstract "2282 STAT3, a member of the signal transducer and activator of transcription family, has the potential to mediate cell survival, growth and differentiation. STAT3 is constitutively activated in numerous cancers including more than 50% of breast cancer types. Previous studies have demonstrated that constitutively activated STAT3 plays an important role in the development and progression of breast cancer by promoting cell proliferation and inhibiting apoptosis. The present study was designed to investigate the potential use of RNA interference (RNAi) to block STAT3 expression and activation as well as any subsequent effect on the growth of human breast cancer cells. We identified a small interfering RNA (siRNA) specific for STAT3. Here, we show that blockade of STAT3 activation by the STAT3 siRNA suppressed STAT3-mediated gene expression and the growth of human breast cancer cells while also inducing apoptotic cell death. These results demonstrate that targeting STAT3 signaling using siRNA may serve as a novel therapeutic strategy for the treatment of breast cancer cells that express constitutively activated STAT3." @default.
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- W3103358366 date "2008-05-01" @default.
- W3103358366 modified "2023-09-22" @default.
- W3103358366 title "RNA interference-mediated gene silencing of signal transducer and activator of transcription 3 (STAT3) induces apoptosis in breast cancer cells" @default.
- W3103358366 hasPublicationYear "2008" @default.
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