Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103374328> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3103374328 endingPage "406" @default.
- W3103374328 startingPage "406" @default.
- W3103374328 abstract "Hyperthyrotropinemia (HT) or reduced thyroid function in Down syndrome (DS) is not uncommon, causes range from glandular dysgenesis to altered hypothalamopituitary axis. In the present study, we have compared hypothyroid Indian children with and without DS (NDS), especially focusing on family history, goiter, and biochemical features.We conducted this retrospective observational study from previous medical records of children with DS (1-17 years) having an elevated TSH (≥5 mIU/L) who were consecutively referred for with HT to Endocrinology OPD of a tertiary care hospital in India. Records from hypothyroid children (1-17 years) without Down Syndrome (NDS) were evaluated as controls. Free thyroxine (FT4), anti-thyroid peroxidase (TPO) antibody were measured and congenital hypothyroidism was excluded in all subjects.Thirty-four DS cases [median age 8 years (IQR: 2-14), M: F = 13:21] and 34 controls [median age 10.5 years (IQR: 7-13.25), M: F = 13:21] were comparable in terms of age and sex, Median age of presentation was significantly earlier in case of DS vs NDS [7 years vs. 10 years]. DS children had significantly less family history of thyroid disorders compared to NDS [14.7% vs 64.7%]. Goiter was significantly less common in patients with DS [DS - 32.25% vs. NDS - 73.5%, P = 0.001]. Anti-TPO antibody positivity was significantly less common in patients with DS [DS- 41% vs. NDS- 73.5%, P = 0.014].There is a significant difference in presentation in hypothyroid children with DS compared to NDS. DS children with hypothyroidism compared to NDS, had earlier presentation, lower incidence of traceable family history, goiter, and anti-TPO-antibody positivity." @default.
- W3103374328 created "2020-11-23" @default.
- W3103374328 creator A5017878150 @default.
- W3103374328 creator A5056264535 @default.
- W3103374328 date "2020-01-01" @default.
- W3103374328 modified "2023-09-25" @default.
- W3103374328 title "High thyroid-stimulating hormone level in down's syndrome: A mere resetting of hypothalamopituitary axis in subclinical hypothyroidism?" @default.
- W3103374328 cites W1964877189 @default.
- W3103374328 cites W1983533487 @default.
- W3103374328 cites W1990018219 @default.
- W3103374328 cites W1990250155 @default.
- W3103374328 cites W2020106045 @default.
- W3103374328 cites W2045821848 @default.
- W3103374328 cites W2048032231 @default.
- W3103374328 cites W2052958565 @default.
- W3103374328 cites W2106574223 @default.
- W3103374328 cites W2131806735 @default.
- W3103374328 cites W2159682860 @default.
- W3103374328 cites W2169956850 @default.
- W3103374328 cites W2172161578 @default.
- W3103374328 cites W2182333276 @default.
- W3103374328 cites W2410332726 @default.
- W3103374328 cites W2594169257 @default.
- W3103374328 cites W2802964978 @default.
- W3103374328 cites W2917640116 @default.
- W3103374328 cites W3003602041 @default.
- W3103374328 cites W2019296776 @default.
- W3103374328 doi "https://doi.org/10.4103/ijem.ijem_422_20" @default.
- W3103374328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7810049" @default.
- W3103374328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33489845" @default.
- W3103374328 hasPublicationYear "2020" @default.
- W3103374328 type Work @default.
- W3103374328 sameAs 3103374328 @default.
- W3103374328 citedByCount "3" @default.
- W3103374328 countsByYear W31033743282023 @default.
- W3103374328 crossrefType "journal-article" @default.
- W3103374328 hasAuthorship W3103374328A5017878150 @default.
- W3103374328 hasAuthorship W3103374328A5056264535 @default.
- W3103374328 hasBestOaLocation W31033743281 @default.
- W3103374328 hasConcept C105702510 @default.
- W3103374328 hasConcept C113280763 @default.
- W3103374328 hasConcept C126322002 @default.
- W3103374328 hasConcept C134018914 @default.
- W3103374328 hasConcept C180650514 @default.
- W3103374328 hasConcept C187212893 @default.
- W3103374328 hasConcept C195910791 @default.
- W3103374328 hasConcept C2777886399 @default.
- W3103374328 hasConcept C2778840127 @default.
- W3103374328 hasConcept C2779258352 @default.
- W3103374328 hasConcept C2779812711 @default.
- W3103374328 hasConcept C2993291352 @default.
- W3103374328 hasConcept C526584372 @default.
- W3103374328 hasConcept C71315377 @default.
- W3103374328 hasConcept C71924100 @default.
- W3103374328 hasConceptScore W3103374328C105702510 @default.
- W3103374328 hasConceptScore W3103374328C113280763 @default.
- W3103374328 hasConceptScore W3103374328C126322002 @default.
- W3103374328 hasConceptScore W3103374328C134018914 @default.
- W3103374328 hasConceptScore W3103374328C180650514 @default.
- W3103374328 hasConceptScore W3103374328C187212893 @default.
- W3103374328 hasConceptScore W3103374328C195910791 @default.
- W3103374328 hasConceptScore W3103374328C2777886399 @default.
- W3103374328 hasConceptScore W3103374328C2778840127 @default.
- W3103374328 hasConceptScore W3103374328C2779258352 @default.
- W3103374328 hasConceptScore W3103374328C2779812711 @default.
- W3103374328 hasConceptScore W3103374328C2993291352 @default.
- W3103374328 hasConceptScore W3103374328C526584372 @default.
- W3103374328 hasConceptScore W3103374328C71315377 @default.
- W3103374328 hasConceptScore W3103374328C71924100 @default.
- W3103374328 hasIssue "5" @default.
- W3103374328 hasLocation W31033743281 @default.
- W3103374328 hasLocation W31033743282 @default.
- W3103374328 hasLocation W31033743283 @default.
- W3103374328 hasLocation W31033743284 @default.
- W3103374328 hasOpenAccess W3103374328 @default.
- W3103374328 hasPrimaryLocation W31033743281 @default.
- W3103374328 hasRelatedWork W117621442 @default.
- W3103374328 hasRelatedWork W2028695521 @default.
- W3103374328 hasRelatedWork W2039456755 @default.
- W3103374328 hasRelatedWork W2063900106 @default.
- W3103374328 hasRelatedWork W2085668963 @default.
- W3103374328 hasRelatedWork W2102878215 @default.
- W3103374328 hasRelatedWork W2151090245 @default.
- W3103374328 hasRelatedWork W3103374328 @default.
- W3103374328 hasRelatedWork W3111963284 @default.
- W3103374328 hasRelatedWork W4321004839 @default.
- W3103374328 hasVolume "24" @default.
- W3103374328 isParatext "false" @default.
- W3103374328 isRetracted "false" @default.
- W3103374328 magId "3103374328" @default.
- W3103374328 workType "article" @default.