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- W3103391331 abstract "Atrial fibrillation (AF) exists on a continuum from paroxysmal to persistent, leading to progressive remodelling of the left atrium (LA). LA global longitudinal strain (LA-GLS) is a sensitive measure of LA function and has been shown to correlate with poor cardiovascular outcomes. We aimed to assess the impact of AF burden on LA-GLS compared to conventional metrics of LA function. Patients with non-valvular AF and permanent pacemaker in-situ were recruited from our outpatient Cardiac Device and Pacing clinics. Those who received transthoracic echocardiogram evaluation within six months of device interrogation were included. We evaluated the relationship between LA metrics and AF burden as assessed on device interrogation. LA-GLS was assessed using vendor-independent software (TomTec Arena, Germany v4.6). We excluded patients with impaired left ventricular ejection fraction (LVEF), cardiac admission in the preceding six months and poor-quality images. Forty patients (mean age 74.02±9.5, 60% men) met the inclusion criteria. 72% had hypertension and 33% had diabetes mellitus. The mean LA-GLS was 20.0±7.4%. Based on lower limit of normal LA-GLS of ≤23%, 60% of the cohort had impaired LA function. All metrics of LA size and function had a significant association to AF burden. LA-GLS had the strongest negative association (r=-0.778, p<0.01) followed by LA ejection fraction (r=-0.540, p<0.01) and LA expansion index (r=-0.535, p<0.01). Indexed LA volumes (r=-.507, p<0.01) showed a weaker association to AF burden compared to functional indices. LA-GLS had a strong negative correlation to AF burden, beyond other metrics of LA size and function." @default.
- W3103391331 created "2020-11-23" @default.
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- W3103391331 date "2020-01-01" @default.
- W3103391331 modified "2023-09-27" @default.
- W3103391331 title "312 Correlation between Atrial Fibrillation Burden and Changes in Indices of Left Atrial Size and Function" @default.
- W3103391331 doi "https://doi.org/10.1016/j.hlc.2020.09.319" @default.
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