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• W3103485184 abstract "The base pair fluctuations and helix untwisting are examined for a circular molecule. A realistic mesoscopic model including twisting degrees of freedom and bending of the molecular axis is proposed. The computational method, based on path integral techniques, simulates a distribution of topoisomers with various twist numbers and finds the energetically most favorable molecular conformation as a function of temperature. The method can predict helical repeat, openings loci and bubble sizes for specific sequences in a broad temperature range. Some results are presented for a short DNA circle recently identified in mammalian cells." @default.
• W3103485184 created "2020-11-23" @default.
• W3103485184 creator A5045132467 @default.
• W3103485184 date "2013-05-28" @default.
• W3103485184 modified "2023-10-14" @default.
• W3103485184 title "Helix untwisting and bubble formation in circular DNA" @default.
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• W3103485184 doi "https://doi.org/10.1063/1.4807381" @default.
• W3103485184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23742521" @default.
• W3103485184 hasPublicationYear "2013" @default.
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