Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103532691> ?p ?o ?g. }
- W3103532691 endingPage "163" @default.
- W3103532691 startingPage "157" @default.
- W3103532691 abstract "Recent approval of several novel agents has dramatically improved outcomes for patients with relapsed and refractory (R/R) B-cell acute lymphoblastic leukemia. Blinatumomab, a bi-specific T-cell engager targeted to CD3 and CD19, inotuzumab ozogamicin (InO), an antibody-drug conjugate to CD22, and tisagenlecleucel, a CD19 chimeric antigen receptor T-cell with a 4-1BB costimulatory domain, have all demonstrated impressive response rates in R/R B-ALL as compared to historic controls. However, important considerations when choosing among these novel agents include clinical features that may impact efficacy, such as relative disease burden, antigen expression, and T-cell function, as well as patient and disease characteristics that may contribute to risk of toxicity. In addition, suitability of the patient for hematopoietic stem cell transplant (HSCT) as well as patient preference must also be considered. This review will focus on factors to weigh when choosing an agent in the setting of R/R disease and important challenges moving forward." @default.
- W3103532691 created "2020-11-23" @default.
- W3103532691 creator A5067126589 @default.
- W3103532691 creator A5090729996 @default.
- W3103532691 date "2020-07-01" @default.
- W3103532691 modified "2023-10-17" @default.
- W3103532691 title "Role of blinatumomab, inotuzumab, and CAR T-cells: Which to choose and how to sequence for patients with relapsed disease" @default.
- W3103532691 cites W1488000644 @default.
- W3103532691 cites W1967512987 @default.
- W3103532691 cites W1977380325 @default.
- W3103532691 cites W1991184842 @default.
- W3103532691 cites W2038414910 @default.
- W3103532691 cites W2042329979 @default.
- W3103532691 cites W2055482234 @default.
- W3103532691 cites W2107925822 @default.
- W3103532691 cites W2118796952 @default.
- W3103532691 cites W2120853229 @default.
- W3103532691 cites W2129702476 @default.
- W3103532691 cites W2167550136 @default.
- W3103532691 cites W2220679566 @default.
- W3103532691 cites W2342423058 @default.
- W3103532691 cites W2384356851 @default.
- W3103532691 cites W2419639370 @default.
- W3103532691 cites W2529226476 @default.
- W3103532691 cites W2583070206 @default.
- W3103532691 cites W2591709377 @default.
- W3103532691 cites W2599899418 @default.
- W3103532691 cites W2606654718 @default.
- W3103532691 cites W2607870782 @default.
- W3103532691 cites W2614019261 @default.
- W3103532691 cites W2688905162 @default.
- W3103532691 cites W2725721905 @default.
- W3103532691 cites W2752517775 @default.
- W3103532691 cites W2755896474 @default.
- W3103532691 cites W2758011629 @default.
- W3103532691 cites W2763751953 @default.
- W3103532691 cites W2768556518 @default.
- W3103532691 cites W2771668512 @default.
- W3103532691 cites W2783032930 @default.
- W3103532691 cites W2787145330 @default.
- W3103532691 cites W2787301955 @default.
- W3103532691 cites W2787621143 @default.
- W3103532691 cites W2790768260 @default.
- W3103532691 cites W2794874600 @default.
- W3103532691 cites W2796022095 @default.
- W3103532691 cites W2805170187 @default.
- W3103532691 cites W2805523469 @default.
- W3103532691 cites W2808514046 @default.
- W3103532691 cites W2890220179 @default.
- W3103532691 cites W2893765519 @default.
- W3103532691 cites W2896845000 @default.
- W3103532691 cites W2900314314 @default.
- W3103532691 cites W2900662379 @default.
- W3103532691 cites W2901278038 @default.
- W3103532691 cites W2905241205 @default.
- W3103532691 cites W2907857910 @default.
- W3103532691 cites W2910798730 @default.
- W3103532691 cites W2912293732 @default.
- W3103532691 cites W2913949832 @default.
- W3103532691 cites W2931981435 @default.
- W3103532691 cites W2942381021 @default.
- W3103532691 cites W2942621614 @default.
- W3103532691 cites W2985081230 @default.
- W3103532691 cites W2990595177 @default.
- W3103532691 cites W2990604751 @default.
- W3103532691 cites W2998345757 @default.
- W3103532691 cites W3012219229 @default.
- W3103532691 cites W3029132671 @default.
- W3103532691 cites W3030234447 @default.
- W3103532691 cites W3030846676 @default.
- W3103532691 cites W4205890623 @default.
- W3103532691 doi "https://doi.org/10.1053/j.seminhematol.2020.11.001" @default.
- W3103532691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33256906" @default.
- W3103532691 hasPublicationYear "2020" @default.
- W3103532691 type Work @default.
- W3103532691 sameAs 3103532691 @default.
- W3103532691 citedByCount "7" @default.
- W3103532691 countsByYear W31035326912021 @default.
- W3103532691 countsByYear W31035326912022 @default.
- W3103532691 countsByYear W31035326912023 @default.
- W3103532691 crossrefType "journal-article" @default.
- W3103532691 hasAuthorship W3103532691A5067126589 @default.
- W3103532691 hasAuthorship W3103532691A5090729996 @default.
- W3103532691 hasConcept C111700020 @default.
- W3103532691 hasConcept C126322002 @default.
- W3103532691 hasConcept C143998085 @default.
- W3103532691 hasConcept C147483822 @default.
- W3103532691 hasConcept C203014093 @default.
- W3103532691 hasConcept C2776090121 @default.
- W3103532691 hasConcept C2777408962 @default.
- W3103532691 hasConcept C2778020697 @default.
- W3103532691 hasConcept C2778957590 @default.
- W3103532691 hasConcept C2779134260 @default.
- W3103532691 hasConcept C2780850621 @default.
- W3103532691 hasConcept C3875195 @default.
- W3103532691 hasConcept C71924100 @default.
- W3103532691 hasConcept C8891405 @default.
- W3103532691 hasConceptScore W3103532691C111700020 @default.