FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103566060> ?p ?o ?g. }

• W3103566060 abstract "A widely studied problem in systems biology is to predict bacterial phenotype from growth conditions, using mechanistic models such as flux balance analysis (FBA). However, the inverse prediction of growth conditions from phenotype is rarely considered. Here we develop a computational framework to carry out this inverse prediction on a computational model of bacterial metabolism. We use FBA to calculate bacterial phenotypes from growth conditions in E. coli, and then we assess how accurately we can predict the original growth conditions from the phenotypes. Prediction is carried out via regularized multinomial regression. Our analysis provides several important physiological and statistical insights. First, we show that by analyzing metabolic end products we can consistently predict growth conditions. Second, prediction is reliable even in the presence of small amounts of impurities. Third, flux through a relatively small number of reactions per growth source (~10) is sufficient for accurate prediction. Fourth, combining the predictions from two separate models, one trained only on carbon sources and one only on nitrogen sources, performs better than models trained to perform joint prediction. Finally, that separate predictions perform better than a more sophisticated joint prediction scheme suggests that carbon and nitrogen utilization pathways, despite jointly affecting cellular growth, may be fairly decoupled in terms of their dependence on specific assortments of molecular precursors." @default.
• W3103566060 created "2020-11-23" @default.
• W3103566060 creator A5009157184 @default.
• W3103566060 creator A5029651089 @default.
• W3103566060 creator A5043439049 @default.
• W3103566060 creator A5053209283 @default.
• W3103566060 creator A5070411498 @default.
• W3103566060 creator A5076204418 @default.
• W3103566060 creator A5079232304 @default.
• W3103566060 date "2014-01-31" @default.
• W3103566060 modified "2023-10-17" @default.
• W3103566060 title "Predicting growth conditions from internal metabolic fluxes in an in-silico model of E. coli" @default.
• W3103566060 cites W1504699676 @default.
• W3103566060 cites W1653457708 @default.
• W3103566060 cites W2007097682 @default.
• W3103566060 cites W2009284641 @default.
• W3103566060 cites W2015549801 @default.
• W3103566060 cites W2022696841 @default.
• W3103566060 cites W2038176196 @default.
• W3103566060 cites W2046254395 @default.
• W3103566060 cites W2061104439 @default.
• W3103566060 cites W2067224994 @default.
• W3103566060 cites W2075283200 @default.
• W3103566060 cites W2078355959 @default.
• W3103566060 cites W2097360283 @default.
• W3103566060 cites W2102164505 @default.
• W3103566060 cites W2107564884 @default.
• W3103566060 cites W2122189635 @default.
• W3103566060 cites W2126176298 @default.
• W3103566060 cites W2127688875 @default.
• W3103566060 cites W2130337886 @default.
• W3103566060 cites W2132555912 @default.
• W3103566060 cites W2135046866 @default.
• W3103566060 cites W2147472054 @default.
• W3103566060 cites W2152479833 @default.
• W3103566060 cites W2154835728 @default.
• W3103566060 cites W2155542617 @default.
• W3103566060 cites W2159614925 @default.
• W3103566060 cites W2160972508 @default.
• W3103566060 cites W2163433435 @default.
• W3103566060 cites W2170427655 @default.
• W3103566060 cites W3098888484 @default.
• W3103566060 doi "https://doi.org/10.1101/002287" @default.
• W3103566060 hasPublicationYear "2014" @default.
• W3103566060 type Work @default.
• W3103566060 sameAs 3103566060 @default.
• W3103566060 citedByCount "1" @default.
• W3103566060 countsByYear W31035660602019 @default.
• W3103566060 crossrefType "posted-content" @default.
• W3103566060 hasAuthorship W3103566060A5009157184 @default.
• W3103566060 hasAuthorship W3103566060A5029651089 @default.
• W3103566060 hasAuthorship W3103566060A5043439049 @default.
• W3103566060 hasAuthorship W3103566060A5053209283 @default.
• W3103566060 hasAuthorship W3103566060A5070411498 @default.
• W3103566060 hasAuthorship W3103566060A5076204418 @default.
• W3103566060 hasAuthorship W3103566060A5079232304 @default.
• W3103566060 hasBestOaLocation W31035660601 @default.
• W3103566060 hasConcept C104317684 @default.
• W3103566060 hasConcept C127413603 @default.
• W3103566060 hasConcept C134018914 @default.
• W3103566060 hasConcept C152662350 @default.
• W3103566060 hasConcept C160941953 @default.
• W3103566060 hasConcept C167091322 @default.
• W3103566060 hasConcept C178790620 @default.
• W3103566060 hasConcept C183696295 @default.
• W3103566060 hasConcept C185592680 @default.
• W3103566060 hasConcept C186060115 @default.
• W3103566060 hasConcept C2775905019 @default.
• W3103566060 hasConcept C41008148 @default.
• W3103566060 hasConcept C54355233 @default.
• W3103566060 hasConcept C62231903 @default.
• W3103566060 hasConcept C68709404 @default.
• W3103566060 hasConcept C70721500 @default.
• W3103566060 hasConcept C86803240 @default.
• W3103566060 hasConceptScore W3103566060C104317684 @default.
• W3103566060 hasConceptScore W3103566060C127413603 @default.
• W3103566060 hasConceptScore W3103566060C134018914 @default.
• W3103566060 hasConceptScore W3103566060C152662350 @default.
• W3103566060 hasConceptScore W3103566060C160941953 @default.
• W3103566060 hasConceptScore W3103566060C167091322 @default.
• W3103566060 hasConceptScore W3103566060C178790620 @default.
• W3103566060 hasConceptScore W3103566060C183696295 @default.
• W3103566060 hasConceptScore W3103566060C185592680 @default.
• W3103566060 hasConceptScore W3103566060C186060115 @default.
• W3103566060 hasConceptScore W3103566060C2775905019 @default.
• W3103566060 hasConceptScore W3103566060C41008148 @default.
• W3103566060 hasConceptScore W3103566060C54355233 @default.
• W3103566060 hasConceptScore W3103566060C62231903 @default.
• W3103566060 hasConceptScore W3103566060C68709404 @default.
• W3103566060 hasConceptScore W3103566060C70721500 @default.
• W3103566060 hasConceptScore W3103566060C86803240 @default.
• W3103566060 hasLocation W31035660601 @default.
• W3103566060 hasLocation W31035660602 @default.
• W3103566060 hasOpenAccess W3103566060 @default.
• W3103566060 hasPrimaryLocation W31035660601 @default.
• W3103566060 hasRelatedWork W1584375372 @default.
• W3103566060 hasRelatedWork W1975566769 @default.
• W3103566060 hasRelatedWork W1977675219 @default.
• W3103566060 hasRelatedWork W1984577552 @default.
• W3103566060 hasRelatedWork W2046546139 @default.

• next