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- W3103734781 abstract "Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular processes that drive life on earth. Despite a large number of successful methods for trapping reaction intermediates, the direct observation of an ongoing reaction has been possible only in rare and exceptional cases. Here, we demonstrate a general method for capturing enzyme catalysis ‘in-action’ by ‘mix-and-inject serial crystallography’. Specifically, we follow the catalytic reaction of the Mycobacterium tuberculosis α-lactamase with the 3 rd generation antibiotic ceftriaxone by time-resolved serial femtosecond crystallography. The results reveal, in near atomic detail, antibiotic cleavage and inactivation on the millisecond to second time scales including the crossover from transition state kinetics to steady-state kinetics. Synopsis An enzymatically catalyzed reaction is initiated by diffusion based mixing of substrate and followed at runtime by time-resolved serial crystallography using a free electron laser." @default.
- W3103734781 created "2020-11-23" @default.
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- W3103734781 date "2017-10-12" @default.
- W3103734781 modified "2023-09-27" @default.
- W3103734781 title "Enzyme Intermediates Captured “on-the-fly” by Mix-and-Inject Serial Crystallography" @default.
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- W3103734781 cites W2116357376 @default.
- W3103734781 cites W2124026197 @default.
- W3103734781 cites W2125096693 @default.
- W3103734781 cites W2133254275 @default.
- W3103734781 cites W2134943478 @default.
- W3103734781 cites W2137209310 @default.
- W3103734781 cites W2139720036 @default.
- W3103734781 cites W2139868632 @default.
- W3103734781 cites W2143455546 @default.
- W3103734781 cites W2143874510 @default.
- W3103734781 cites W2147231326 @default.
- W3103734781 cites W2152814571 @default.
- W3103734781 cites W2157268584 @default.
- W3103734781 cites W2159759190 @default.
- W3103734781 cites W2162014979 @default.
- W3103734781 cites W2180229411 @default.
- W3103734781 cites W2180262932 @default.
- W3103734781 cites W2252581239 @default.
- W3103734781 cites W2346425069 @default.
- W3103734781 cites W2398058485 @default.