FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103752265> ?p ?o ?g. }

• W3103752265 endingPage "129004" @default.
• W3103752265 startingPage "129004" @default.
• W3103752265 abstract "Perfluorooctanoic acid (PFOA), an environmental pollutant, is widely engaged in industrial products and tends to accumulate in the liver. Emerging evidence has suggested that the gut microbiome is a pivotal player in maintaining animal health and can potentially altered by xenobiotic. However, few studies explored whether PFOA-induced liver injury is associated with gut microbiota dysbiosis. In the present study, the effects of subacute and subchronic PFOA exposure on liver and gut microbiota in C57BL/6J mice were investigated. Our findings showed that both subacute and subchronic exposure to PFOA induced the liver inflammation, disrupted antioxidative homeostasis and caused liver histological abnormalities with detectable hepatomegaly, ultimately triggering liver injury. Besides, 16S rRNA sequencing analysis revealed that subacute PFOA exposure caused significant changes in the abundances of intestinal flora known to contribute to liver inflammation and oxidative stress, such as the Dehalobacterium and Bacteroides genera. Exposure to subchronic toxicity mainly induced the decrease in commensal probiotics including Lactobacillus and Bifidobacterium genera, which are potentially beneficial to liver damage, compared with that in the untreated group. They also resulted in disturbed functional capabilities of the microbial communities by a Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) analysis. Additionally, the levels of short-chain fatty acids (SCFAs), especially butyric acid, were significantly reduced by PFOA administration. Collectively, our observations suggested that liver damage induced by both subacute and subchronic PFOA exposures probably partly related to the gut microbiota dysbiosis and provided a new insight into the role of PFOA in liver injury." @default.
• W3103752265 created "2020-11-23" @default.
• W3103752265 creator A5017541508 @default.
• W3103752265 creator A5030921116 @default.
• W3103752265 creator A5049341927 @default.
• W3103752265 creator A5054717095 @default.
• W3103752265 creator A5065925398 @default.
• W3103752265 creator A5075902396 @default.
• W3103752265 creator A5083247969 @default.
• W3103752265 date "2021-03-01" @default.
• W3103752265 modified "2023-10-11" @default.
• W3103752265 title "Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis" @default.
• W3103752265 cites W1986258895 @default.
• W3103752265 cites W1993127959 @default.
• W3103752265 cites W1993650845 @default.
• W3103752265 cites W2014235257 @default.
• W3103752265 cites W2034801500 @default.
• W3103752265 cites W2072792818 @default.
• W3103752265 cites W2072970694 @default.
• W3103752265 cites W2091363025 @default.
• W3103752265 cites W2110300022 @default.
• W3103752265 cites W2134031962 @default.
• W3103752265 cites W2144493532 @default.
• W3103752265 cites W2153644921 @default.
• W3103752265 cites W2167062509 @default.
• W3103752265 cites W2167497582 @default.
• W3103752265 cites W2174322658 @default.
• W3103752265 cites W2250981334 @default.
• W3103752265 cites W2319085923 @default.
• W3103752265 cites W2339991872 @default.
• W3103752265 cites W2411464510 @default.
• W3103752265 cites W2471287187 @default.
• W3103752265 cites W2507801963 @default.
• W3103752265 cites W2556805998 @default.
• W3103752265 cites W2566657364 @default.
• W3103752265 cites W2589387961 @default.
• W3103752265 cites W2590249136 @default.
• W3103752265 cites W2602405366 @default.
• W3103752265 cites W2607311572 @default.
• W3103752265 cites W2721974427 @default.
• W3103752265 cites W2752477184 @default.
• W3103752265 cites W2768507206 @default.
• W3103752265 cites W2802744456 @default.
• W3103752265 cites W2894675275 @default.
• W3103752265 cites W2895885253 @default.
• W3103752265 cites W2898326715 @default.
• W3103752265 cites W2902119722 @default.
• W3103752265 cites W2941732771 @default.
• W3103752265 cites W2943868422 @default.
• W3103752265 cites W2959698202 @default.
• W3103752265 cites W2964066412 @default.
• W3103752265 cites W2969766611 @default.
• W3103752265 cites W2976021207 @default.
• W3103752265 cites W3015226650 @default.
• W3103752265 cites W3028491493 @default.
• W3103752265 doi "https://doi.org/10.1016/j.chemosphere.2020.129004" @default.
• W3103752265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33279240" @default.
• W3103752265 hasPublicationYear "2021" @default.
• W3103752265 type Work @default.
• W3103752265 sameAs 3103752265 @default.
• W3103752265 citedByCount "39" @default.
• W3103752265 countsByYear W31037522652021 @default.
• W3103752265 countsByYear W31037522652022 @default.
• W3103752265 countsByYear W31037522652023 @default.
• W3103752265 crossrefType "journal-article" @default.
• W3103752265 hasAuthorship W3103752265A5017541508 @default.
• W3103752265 hasAuthorship W3103752265A5030921116 @default.
• W3103752265 hasAuthorship W3103752265A5049341927 @default.
• W3103752265 hasAuthorship W3103752265A5054717095 @default.
• W3103752265 hasAuthorship W3103752265A5065925398 @default.
• W3103752265 hasAuthorship W3103752265A5075902396 @default.
• W3103752265 hasAuthorship W3103752265A5083247969 @default.
• W3103752265 hasConcept C143121216 @default.
• W3103752265 hasConcept C203014093 @default.
• W3103752265 hasConcept C2775979320 @default.
• W3103752265 hasConcept C2776151105 @default.
• W3103752265 hasConcept C2776637226 @default.
• W3103752265 hasConcept C2777165150 @default.
• W3103752265 hasConcept C2778168646 @default.
• W3103752265 hasConcept C42407357 @default.
• W3103752265 hasConcept C523546767 @default.
• W3103752265 hasConcept C539455810 @default.
• W3103752265 hasConcept C54355233 @default.
• W3103752265 hasConcept C55493867 @default.
• W3103752265 hasConcept C60644358 @default.
• W3103752265 hasConcept C86803240 @default.
• W3103752265 hasConcept C89423630 @default.
• W3103752265 hasConcept C98274493 @default.
• W3103752265 hasConceptScore W3103752265C143121216 @default.
• W3103752265 hasConceptScore W3103752265C203014093 @default.
• W3103752265 hasConceptScore W3103752265C2775979320 @default.
• W3103752265 hasConceptScore W3103752265C2776151105 @default.
• W3103752265 hasConceptScore W3103752265C2776637226 @default.
• W3103752265 hasConceptScore W3103752265C2777165150 @default.
• W3103752265 hasConceptScore W3103752265C2778168646 @default.
• W3103752265 hasConceptScore W3103752265C42407357 @default.
• W3103752265 hasConceptScore W3103752265C523546767 @default.
• W3103752265 hasConceptScore W3103752265C539455810 @default.

• next