FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103802408> ?p ?o ?g. }

• W3103802408 endingPage "113562" @default.
• W3103802408 startingPage "113562" @default.
• W3103802408 abstract "Shen-Fu Decoction (SFD), a classic Traditional Chinese paired herb formulation, has been widely used for the treatment of sepsis in China. This study was carried out to assess the effects of SFD in sepsis-induced intestinal permeability and intestinal epithelial tight junction damage in rats with sepsis. A rat model of sepsis was created by cecal ligation and puncture (CLP). Rats in Sham and CLP + vehicle groups received equal distilled water, while rats in SFD group were treated by gavage of SFD (3 mg/kg, twice a day) for 72h. Mortality, sepsis-induced peritoneal inflammation, intestinal and liver histopathology damage, intestinal permeability (serum FITC-dextran and D-lactate), serum LPS, serum inflammation (PCT, TNF-α, and IL-6), and liver function (AST and ALT) were evaluated. The levels of zonula occluden (ZO-1), Occludin, Claudin-1 were analyzed by Real-time quantitative PCR and Western blotting (WB) respectively. Vasodilator-stimulated phosphoprotein (VASP) and p-VASP in intestinal epithelium were analyzed by WB. Our study showed that SFD markedly reduced the mortality rate of CLP rats, prevented intestine and liver damage, relieved sepsis-induced intestinal permeability and inflammation elevation, ameliorated sepsis-induced impaired intestinal permeability by regulating the expression of ZO-1, Occludin, Claudin-1 and p-VASP. The herbal formula SFD may be useful for reducing sepsis-induced organic damage and mortality by ameliorating the condition of sepsis-induced intestinal permeability by regulating tight junction proteins and p-VASP." @default.
• W3103802408 created "2020-11-23" @default.
• W3103802408 creator A5006250732 @default.
• W3103802408 creator A5017227883 @default.
• W3103802408 creator A5043430437 @default.
• W3103802408 creator A5053194944 @default.
• W3103802408 creator A5058780708 @default.
• W3103802408 date "2021-03-01" @default.
• W3103802408 modified "2023-09-26" @default.
• W3103802408 title "Shen-Fu Decoction could ameliorate intestinal permeability by regulating the intestinal expression of tight junction proteins and p-VASP in septic rats" @default.
• W3103802408 cites W1507554286 @default.
• W3103802408 cites W1901090210 @default.
• W3103802408 cites W1989992071 @default.
• W3103802408 cites W2003254025 @default.
• W3103802408 cites W2006223802 @default.
• W3103802408 cites W2007582093 @default.
• W3103802408 cites W2012591069 @default.
• W3103802408 cites W2016349967 @default.
• W3103802408 cites W2036294223 @default.
• W3103802408 cites W2040692282 @default.
• W3103802408 cites W2046199571 @default.
• W3103802408 cites W2059699981 @default.
• W3103802408 cites W2060031798 @default.
• W3103802408 cites W2098375616 @default.
• W3103802408 cites W2100403812 @default.
• W3103802408 cites W2111803831 @default.
• W3103802408 cites W2115523048 @default.
• W3103802408 cites W2126378968 @default.
• W3103802408 cites W2194742432 @default.
• W3103802408 cites W2278600110 @default.
• W3103802408 cites W2312910972 @default.
• W3103802408 cites W2330026276 @default.
• W3103802408 cites W2331523906 @default.
• W3103802408 cites W2510962876 @default.
• W3103802408 cites W2573440234 @default.
• W3103802408 cites W2612876782 @default.
• W3103802408 cites W2762844444 @default.
• W3103802408 cites W2791628944 @default.
• W3103802408 cites W2792511898 @default.
• W3103802408 cites W2795260477 @default.
• W3103802408 cites W2795382761 @default.
• W3103802408 cites W2799359461 @default.
• W3103802408 cites W2815658273 @default.
• W3103802408 cites W2908761909 @default.
• W3103802408 cites W2940407405 @default.
• W3103802408 cites W2943440977 @default.
• W3103802408 cites W2947375759 @default.
• W3103802408 cites W2955652692 @default.
• W3103802408 cites W2999280903 @default.
• W3103802408 cites W3012014464 @default.
• W3103802408 doi "https://doi.org/10.1016/j.jep.2020.113562" @default.
• W3103802408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33217519" @default.
• W3103802408 hasPublicationYear "2021" @default.
• W3103802408 type Work @default.
• W3103802408 sameAs 3103802408 @default.
• W3103802408 citedByCount "8" @default.
• W3103802408 countsByYear W31038024082021 @default.
• W3103802408 countsByYear W31038024082022 @default.
• W3103802408 countsByYear W31038024082023 @default.
• W3103802408 crossrefType "journal-article" @default.
• W3103802408 hasAuthorship W3103802408A5006250732 @default.
• W3103802408 hasAuthorship W3103802408A5017227883 @default.
• W3103802408 hasAuthorship W3103802408A5043430437 @default.
• W3103802408 hasAuthorship W3103802408A5053194944 @default.
• W3103802408 hasAuthorship W3103802408A5058780708 @default.
• W3103802408 hasConcept C126322002 @default.
• W3103802408 hasConcept C177779419 @default.
• W3103802408 hasConcept C185592680 @default.
• W3103802408 hasConcept C190409667 @default.
• W3103802408 hasConcept C203014093 @default.
• W3103802408 hasConcept C2775962179 @default.
• W3103802408 hasConcept C2776914184 @default.
• W3103802408 hasConcept C2777649898 @default.
• W3103802408 hasConcept C2778384902 @default.
• W3103802408 hasConcept C2781071285 @default.
• W3103802408 hasConcept C55493867 @default.
• W3103802408 hasConcept C71924100 @default.
• W3103802408 hasConcept C98274493 @default.
• W3103802408 hasConceptScore W3103802408C126322002 @default.
• W3103802408 hasConceptScore W3103802408C177779419 @default.
• W3103802408 hasConceptScore W3103802408C185592680 @default.
• W3103802408 hasConceptScore W3103802408C190409667 @default.
• W3103802408 hasConceptScore W3103802408C203014093 @default.
• W3103802408 hasConceptScore W3103802408C2775962179 @default.
• W3103802408 hasConceptScore W3103802408C2776914184 @default.
• W3103802408 hasConceptScore W3103802408C2777649898 @default.
• W3103802408 hasConceptScore W3103802408C2778384902 @default.
• W3103802408 hasConceptScore W3103802408C2781071285 @default.
• W3103802408 hasConceptScore W3103802408C55493867 @default.
• W3103802408 hasConceptScore W3103802408C71924100 @default.
• W3103802408 hasConceptScore W3103802408C98274493 @default.
• W3103802408 hasFunder F4320321001 @default.
• W3103802408 hasFunder F4320335787 @default.
• W3103802408 hasLocation W31038024081 @default.
• W3103802408 hasOpenAccess W3103802408 @default.
• W3103802408 hasPrimaryLocation W31038024081 @default.
• W3103802408 hasRelatedWork W2042092889 @default.
• W3103802408 hasRelatedWork W2069225082 @default.

• next