Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103807923> ?p ?o ?g. }
- W3103807923 endingPage "e05528" @default.
- W3103807923 startingPage "e05528" @default.
- W3103807923 abstract "The outbreak of COVID-19 was originated from China, responsible for Several Acute Respiratory Syndrome (SARS). Scientists are forced to develop vaccine and effective drugs to control COVID-19 infection. To develop effective vaccine for SARS – COVID 19, immunoinformatics and computational approaches could helps to design successful vaccine against this biggest danger for humanity. Here we used various in – silico approaches to designed vaccine against COVID-19. To develop vaccine, we target S- protein, expressed on the virus surface plays important role in COVID-19 infection. We identified 12 B-cell, 9 T-helper and 20 Cytotoxic T-cell epitope based on criteria of selection. The predicted epitopes were link simultaneously with GPGPG & AAY linkers. The β-defensin was used as adjuvant, linked with selected epitope by using EAAAK linker. For vaccine construct justification we analysed its immunogenicity, allergenicity and physiochemical properties. Our study revealed that vaccine was non toxic, immunogenic and antigenic in nature and covers 98.6% of world population, important for vaccine effectively. In- silico cloning was used to analyse its expression in vector. Molecular docking was performed to study the interaction of construct with TLR (TLR3, TLR4, and TLR9) molecules. The immune simulation was conducted and conformed that our vaccine constructs can induces both acquired and humoral immunity effectively against COVID-19 at very low concentration, but along with bioinformatics study we need to conduct experiment in laboratory to validate its safety and effectiveness." @default.
- W3103807923 created "2020-11-23" @default.
- W3103807923 creator A5014205561 @default.
- W3103807923 creator A5074676281 @default.
- W3103807923 creator A5089933677 @default.
- W3103807923 date "2020-11-01" @default.
- W3103807923 modified "2023-09-23" @default.
- W3103807923 title "Designing spike protein (S-Protein) based multi-epitope peptide vaccine against SARS COVID-19 by immunoinformatics" @default.
- W3103807923 cites W1526839960 @default.
- W3103807923 cites W1966126294 @default.
- W3103807923 cites W1966238900 @default.
- W3103807923 cites W1981264193 @default.
- W3103807923 cites W1991542542 @default.
- W3103807923 cites W1992192767 @default.
- W3103807923 cites W1993568862 @default.
- W3103807923 cites W2003805630 @default.
- W3103807923 cites W2012625502 @default.
- W3103807923 cites W2026618142 @default.
- W3103807923 cites W2035014358 @default.
- W3103807923 cites W2037130111 @default.
- W3103807923 cites W2040991839 @default.
- W3103807923 cites W2066609648 @default.
- W3103807923 cites W2074986801 @default.
- W3103807923 cites W2080876451 @default.
- W3103807923 cites W2100350770 @default.
- W3103807923 cites W2110298304 @default.
- W3103807923 cites W2111376288 @default.
- W3103807923 cites W2118612771 @default.
- W3103807923 cites W2118817344 @default.
- W3103807923 cites W2168036974 @default.
- W3103807923 cites W2169379013 @default.
- W3103807923 cites W2336040088 @default.
- W3103807923 cites W2766504265 @default.
- W3103807923 cites W2793022939 @default.
- W3103807923 cites W2802312498 @default.
- W3103807923 cites W2886321229 @default.
- W3103807923 cites W2896686120 @default.
- W3103807923 cites W2903899730 @default.
- W3103807923 cites W2911658570 @default.
- W3103807923 cites W2922503279 @default.
- W3103807923 cites W2948622157 @default.
- W3103807923 cites W2972594981 @default.
- W3103807923 cites W2998670069 @default.
- W3103807923 cites W2999318660 @default.
- W3103807923 cites W3003217347 @default.
- W3103807923 cites W3004318991 @default.
- W3103807923 cites W3004999328 @default.
- W3103807923 cites W3009798798 @default.
- W3103807923 cites W3010441732 @default.
- W3103807923 doi "https://doi.org/10.1016/j.heliyon.2020.e05528" @default.
- W3103807923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7667438" @default.
- W3103807923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33225084" @default.
- W3103807923 hasPublicationYear "2020" @default.
- W3103807923 type Work @default.
- W3103807923 sameAs 3103807923 @default.
- W3103807923 citedByCount "18" @default.
- W3103807923 countsByYear W31038079232020 @default.
- W3103807923 countsByYear W31038079232021 @default.
- W3103807923 countsByYear W31038079232022 @default.
- W3103807923 countsByYear W31038079232023 @default.
- W3103807923 crossrefType "journal-article" @default.
- W3103807923 hasAuthorship W3103807923A5014205561 @default.
- W3103807923 hasAuthorship W3103807923A5074676281 @default.
- W3103807923 hasAuthorship W3103807923A5089933677 @default.
- W3103807923 hasBestOaLocation W31038079231 @default.
- W3103807923 hasConcept C104317684 @default.
- W3103807923 hasConcept C147483822 @default.
- W3103807923 hasConcept C159047783 @default.
- W3103807923 hasConcept C195616568 @default.
- W3103807923 hasConcept C203014093 @default.
- W3103807923 hasConcept C2775905019 @default.
- W3103807923 hasConcept C2776789287 @default.
- W3103807923 hasConcept C2777863537 @default.
- W3103807923 hasConcept C2780868878 @default.
- W3103807923 hasConcept C54355233 @default.
- W3103807923 hasConcept C70721500 @default.
- W3103807923 hasConcept C86803240 @default.
- W3103807923 hasConceptScore W3103807923C104317684 @default.
- W3103807923 hasConceptScore W3103807923C147483822 @default.
- W3103807923 hasConceptScore W3103807923C159047783 @default.
- W3103807923 hasConceptScore W3103807923C195616568 @default.
- W3103807923 hasConceptScore W3103807923C203014093 @default.
- W3103807923 hasConceptScore W3103807923C2775905019 @default.
- W3103807923 hasConceptScore W3103807923C2776789287 @default.
- W3103807923 hasConceptScore W3103807923C2777863537 @default.
- W3103807923 hasConceptScore W3103807923C2780868878 @default.
- W3103807923 hasConceptScore W3103807923C54355233 @default.
- W3103807923 hasConceptScore W3103807923C70721500 @default.
- W3103807923 hasConceptScore W3103807923C86803240 @default.
- W3103807923 hasIssue "11" @default.
- W3103807923 hasLocation W31038079231 @default.
- W3103807923 hasLocation W31038079232 @default.
- W3103807923 hasOpenAccess W3103807923 @default.
- W3103807923 hasPrimaryLocation W31038079231 @default.
- W3103807923 hasRelatedWork W1985438190 @default.
- W3103807923 hasRelatedWork W2009840051 @default.
- W3103807923 hasRelatedWork W2019183242 @default.
- W3103807923 hasRelatedWork W2026873515 @default.