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- W3103869488 abstract "Abstract Bacteria invest in a slow-growing subpopulation, called persisters , to ensure survival in the face of uncertainty. This hedging strategy, which we term cellular hedging , is remarkably similar to financial hedging where diversifying an investment portfolio protects against economic uncertainty. We provide a new theoretical foundation for understanding cellular hedging by unifying the study of biological population dynamics and the mathematics of financial risk management. Our approach explicitly incorporates environmental volatility as a stochastic process, and we study the persister strategy that maximises the expected per-capita growth rate by formulating an optimal control problem. We demonstrate that persistence is only advantageous in the presence of environmental volatility. Analytical and simulation results are consistent with experimental observations and suggest novel experiments to further the understanding of persistence. Overall, we provide a new way of conceptualising and modelling cellular decision making by unifying previously disparate theory from mathematical biology and finance." @default.
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- W3103869488 date "2019-12-20" @default.
- W3103869488 modified "2023-09-26" @default.
- W3103869488 title "Persistence as an optimal hedging strategy for bacteria in volatile environments" @default.
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