FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103889497> ?p ?o ?g. }

• W3103889497 endingPage "20" @default.
• W3103889497 startingPage "13" @default.
• W3103889497 abstract "The graphic symbolizes the well-known observation that cardiac electrophysiology changes at different times of day. Clinically, sudden cardiac death is shown to have a time of day increase incidence for certain types of heart disease. To better understand how environment and gene interactions contribute to cardiac electrophysiology, several investigators have generated transgenic mouse models that disrupt circadian clocks in different tissues including the heart. These studies show a role for functional circadian clocks in regulating heart rate, the development of dilated cardiomyopathy, cardiac repolarization, and cardiac ion channels. Daily changes in the incidence of sudden cardiac death (SCD) reveal an interaction between environmental rhythms and internal circadian rhythms. Circadian rhythms are physiological rhythms that alter physiology to anticipate daily changes in the environment. They reflect coordinated activity of cellular circadian clocks that exist throughout the body. This review provides an overview of the state of the field by summarizing the results of several different transgenic mouse models that disrupt the function of circadian clocks throughout the body, in cardiomyocytes, or in adult cardiomyocytes. These studies identify important roles for circadian clocks in regulating heart rate, ventricular repolarization, arrhythmogenesis, and the functional expression of cardiac ion channels. They highlight a new dimension in the regulation of cardiac excitability and represent initial forays into understanding the complexities of how time impacts the functional regulation of ion channels, cardiac excitability, and time of day changes in the incidence of SCD." @default.
• W3103889497 created "2020-11-23" @default.
• W3103889497 creator A5001162733 @default.
• W3103889497 creator A5013571817 @default.
• W3103889497 creator A5021755362 @default.
• W3103889497 creator A5022972976 @default.
• W3103889497 creator A5036757646 @default.
• W3103889497 creator A5068328556 @default.
• W3103889497 creator A5078047301 @default.
• W3103889497 creator A5085574358 @default.
• W3103889497 date "2021-04-01" @default.
• W3103889497 modified "2023-09-27" @default.
• W3103889497 title "Circadian clocks regulate cardiac arrhythmia susceptibility, repolarization, and ion channels" @default.
• W3103889497 cites W1482377585 @default.
• W3103889497 cites W1590841714 @default.
• W3103889497 cites W160020775 @default.
• W3103889497 cites W1661083499 @default.
• W3103889497 cites W1744822607 @default.
• W3103889497 cites W1930786993 @default.
• W3103889497 cites W1968098810 @default.
• W3103889497 cites W1973788573 @default.
• W3103889497 cites W1975530669 @default.
• W3103889497 cites W1989011389 @default.
• W3103889497 cites W1991081479 @default.
• W3103889497 cites W1992494470 @default.
• W3103889497 cites W1992726958 @default.
• W3103889497 cites W1996829258 @default.
• W3103889497 cites W2004182744 @default.
• W3103889497 cites W2006623829 @default.
• W3103889497 cites W2009132775 @default.
• W3103889497 cites W2016081512 @default.
• W3103889497 cites W2021001937 @default.
• W3103889497 cites W2021438486 @default.
• W3103889497 cites W2023075865 @default.
• W3103889497 cites W2027410128 @default.
• W3103889497 cites W2027472801 @default.
• W3103889497 cites W2030067432 @default.
• W3103889497 cites W2031379791 @default.
• W3103889497 cites W2032665153 @default.
• W3103889497 cites W2035809873 @default.
• W3103889497 cites W2037124960 @default.
• W3103889497 cites W2056395995 @default.
• W3103889497 cites W2059142008 @default.
• W3103889497 cites W2064495012 @default.
• W3103889497 cites W2065793682 @default.
• W3103889497 cites W2066183013 @default.
• W3103889497 cites W2066229820 @default.
• W3103889497 cites W2066483001 @default.
• W3103889497 cites W2067026046 @default.
• W3103889497 cites W2068483283 @default.
• W3103889497 cites W2073036589 @default.
• W3103889497 cites W2074705578 @default.
• W3103889497 cites W2084770232 @default.
• W3103889497 cites W2085834180 @default.
• W3103889497 cites W2087466289 @default.
• W3103889497 cites W2089889539 @default.
• W3103889497 cites W2093671121 @default.
• W3103889497 cites W2097912415 @default.
• W3103889497 cites W2102584682 @default.
• W3103889497 cites W2104603409 @default.
• W3103889497 cites W2108988707 @default.
• W3103889497 cites W2110792462 @default.
• W3103889497 cites W2113297137 @default.
• W3103889497 cites W2120115128 @default.
• W3103889497 cites W2125877140 @default.
• W3103889497 cites W2129910735 @default.
• W3103889497 cites W2129954925 @default.
• W3103889497 cites W2132267388 @default.
• W3103889497 cites W2135667255 @default.
• W3103889497 cites W2139030135 @default.
• W3103889497 cites W2145967879 @default.
• W3103889497 cites W2149626782 @default.
• W3103889497 cites W2150076905 @default.
• W3103889497 cites W2151429542 @default.
• W3103889497 cites W2157691027 @default.
• W3103889497 cites W2159664208 @default.
• W3103889497 cites W2161506093 @default.
• W3103889497 cites W2164628441 @default.
• W3103889497 cites W2164824098 @default.
• W3103889497 cites W2165564780 @default.
• W3103889497 cites W2169597375 @default.
• W3103889497 cites W2194126010 @default.
• W3103889497 cites W2323130763 @default.
• W3103889497 cites W2400568995 @default.
• W3103889497 cites W2807228974 @default.
• W3103889497 cites W2883842368 @default.
• W3103889497 cites W2889184839 @default.
• W3103889497 cites W2890109396 @default.
• W3103889497 cites W2893054388 @default.
• W3103889497 cites W2913705661 @default.
• W3103889497 cites W2925340173 @default.
• W3103889497 cites W2981148730 @default.
• W3103889497 doi "https://doi.org/10.1016/j.coph.2020.09.015" @default.
• W3103889497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8240636" @default.
• W3103889497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33181392" @default.
• W3103889497 hasPublicationYear "2021" @default.
• W3103889497 type Work @default.
• W3103889497 sameAs 3103889497 @default.

• next