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- W3103890422 abstract "Protein secondary structure prediction is a fundamental precursor to many bioinformatics tasks. Nearly all state-of-the-art tools when computing their secondary structure prediction do not explicitly leverage the vast number of proteins whose structure is known. Leveraging this additional information in a template-based method has the potential to significantly boost prediction accuracy. We present a new hybrid approach to secondary structure prediction that gains the advantages of both template-based and template-free methods. Our core template-based method is an algorithmic approach that uses metric-space nearest neighbor search over a template database of fixed-length amino-acid words to determine estimated class-membership probabilities for each residue in the protein. These probabilities are then input to a dynamic programming algorithm that finds a physically-valid maximum-likelihood prediction for the entire protein. Our hybrid approach exploits a novel accuracy estimator for our core method, that estimates the unknown true accuracy of its prediction, to discern when to switch between template-based and template-free methods. On challenging CASP benchmarks, the hybrid approach boosts the state-of-the-art Q8 accuracy by as much as 10%, and Q3 accuracy by as much as 3%, yielding the most accurate method currently available for both 3- and 8-state secondary structure prediction." @default.
- W3103890422 created "2020-11-23" @default.
- W3103890422 creator A5004770693 @default.
- W3103890422 creator A5083998316 @default.
- W3103890422 date "2020-09-21" @default.
- W3103890422 modified "2023-10-14" @default.
- W3103890422 title "Boosting the accuracy of protein secondary structure prediction through nearest neighbor search and method hybridization" @default.
- W3103890422 doi "https://doi.org/10.1145/3388440.3414212" @default.
- W3103890422 hasPublicationYear "2020" @default.
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