FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103950135> ?p ?o ?g. }

• W3103950135 endingPage "e3000872" @default.
• W3103950135 startingPage "e3000872" @default.
• W3103950135 abstract "Metabolic reprogramming to fulfill the biosynthetic and bioenergetic demands of cancer cells has aroused great interest in recent years. However, metabolic reprogramming for cancer metastasis has not been well elucidated. Here, we screened a subpopulation of breast cancer cells with highly metastatic capacity to the lung in mice and investigated the metabolic alternations by analyzing the metabolome and the transcriptome, which were confirmed in breast cancer cells, mouse models, and patients’ tissues. The effects and the mechanisms of nucleotide de novo synthesis in cancer metastasis were further evaluated in vitro and in vivo. In our study, we report an increased nucleotide de novo synthesis as a key metabolic hallmark in metastatic breast cancer cells and revealed that enforced nucleotide de novo synthesis was enough to drive the metastasis of breast cancer cells. An increased key metabolite of de novo synthesis, guanosine-5'-triphosphate (GTP), is able to generate more cyclic guanosine monophosphate (cGMP) to activate cGMP-dependent protein kinases PKG and downstream MAPK pathway, resulting in the increased tumor cell stemness and metastasis. Blocking de novo synthesis by silencing phosphoribosylpyrophosphate synthetase 2 (PRPS2) can effectively decrease the stemness of breast cancer cells and reduce the lung metastasis. More interestingly, in breast cancer patients, the level of plasma uric acid (UA), a downstream metabolite of purine, is tightly correlated with patient’s survival. Our study uncovered that increased de novo synthesis is a metabolic hallmark of metastatic breast cancer cells and its metabolites can regulate the signaling pathway to promote the stemness and metastasis of breast cancer." @default.
• W3103950135 created "2020-11-23" @default.
• W3103950135 creator A5019184126 @default.
• W3103950135 creator A5021561362 @default.
• W3103950135 creator A5024126340 @default.
• W3103950135 creator A5061178047 @default.
• W3103950135 creator A5064499518 @default.
• W3103950135 creator A5074960198 @default.
• W3103950135 creator A5082020327 @default.
• W3103950135 creator A5085903306 @default.
• W3103950135 creator A5086201087 @default.
• W3103950135 creator A5091082393 @default.
• W3103950135 date "2020-11-13" @default.
• W3103950135 modified "2023-10-18" @default.
• W3103950135 title "Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway" @default.
• W3103950135 cites W1587916292 @default.
• W3103950135 cites W1986310991 @default.
• W3103950135 cites W1992962914 @default.
• W3103950135 cites W1996628084 @default.
• W3103950135 cites W2000144783 @default.
• W3103950135 cites W2003992789 @default.
• W3103950135 cites W2006315039 @default.
• W3103950135 cites W2016956375 @default.
• W3103950135 cites W2025372788 @default.
• W3103950135 cites W2026170688 @default.
• W3103950135 cites W2029862275 @default.
• W3103950135 cites W2036008499 @default.
• W3103950135 cites W2036942985 @default.
• W3103950135 cites W2041237929 @default.
• W3103950135 cites W2043778347 @default.
• W3103950135 cites W2073120856 @default.
• W3103950135 cites W2102278945 @default.
• W3103950135 cites W2116201681 @default.
• W3103950135 cites W2122696037 @default.
• W3103950135 cites W2123934866 @default.
• W3103950135 cites W2124985265 @default.
• W3103950135 cites W2131466790 @default.
• W3103950135 cites W2258318060 @default.
• W3103950135 cites W2262569734 @default.
• W3103950135 cites W2586265133 @default.
• W3103950135 cites W2602955340 @default.
• W3103950135 cites W2738778921 @default.
• W3103950135 cites W2765597781 @default.
• W3103950135 cites W2803664483 @default.
• W3103950135 cites W2913043277 @default.
• W3103950135 cites W2917237457 @default.
• W3103950135 cites W2920825919 @default.
• W3103950135 cites W2945731602 @default.
• W3103950135 cites W2972278366 @default.
• W3103950135 cites W2973455289 @default.
• W3103950135 cites W4210371423 @default.
• W3103950135 doi "https://doi.org/10.1371/journal.pbio.3000872" @default.
• W3103950135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7688141" @default.
• W3103950135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33186350" @default.
• W3103950135 hasPublicationYear "2020" @default.
• W3103950135 type Work @default.
• W3103950135 sameAs 3103950135 @default.
• W3103950135 citedByCount "49" @default.
• W3103950135 countsByYear W31039501352021 @default.
• W3103950135 countsByYear W31039501352022 @default.
• W3103950135 countsByYear W31039501352023 @default.
• W3103950135 crossrefType "journal-article" @default.
• W3103950135 hasAuthorship W3103950135A5019184126 @default.
• W3103950135 hasAuthorship W3103950135A5021561362 @default.
• W3103950135 hasAuthorship W3103950135A5024126340 @default.
• W3103950135 hasAuthorship W3103950135A5061178047 @default.
• W3103950135 hasAuthorship W3103950135A5064499518 @default.
• W3103950135 hasAuthorship W3103950135A5074960198 @default.
• W3103950135 hasAuthorship W3103950135A5082020327 @default.
• W3103950135 hasAuthorship W3103950135A5085903306 @default.
• W3103950135 hasAuthorship W3103950135A5086201087 @default.
• W3103950135 hasAuthorship W3103950135A5091082393 @default.
• W3103950135 hasBestOaLocation W31039501351 @default.
• W3103950135 hasConcept C121608353 @default.
• W3103950135 hasConcept C2779013556 @default.
• W3103950135 hasConcept C502942594 @default.
• W3103950135 hasConcept C530470458 @default.
• W3103950135 hasConcept C54355233 @default.
• W3103950135 hasConcept C86803240 @default.
• W3103950135 hasConcept C96232424 @default.
• W3103950135 hasConceptScore W3103950135C121608353 @default.
• W3103950135 hasConceptScore W3103950135C2779013556 @default.
• W3103950135 hasConceptScore W3103950135C502942594 @default.
• W3103950135 hasConceptScore W3103950135C530470458 @default.
• W3103950135 hasConceptScore W3103950135C54355233 @default.
• W3103950135 hasConceptScore W3103950135C86803240 @default.
• W3103950135 hasConceptScore W3103950135C96232424 @default.
• W3103950135 hasFunder F4320321001 @default.
• W3103950135 hasFunder F4320323993 @default.
• W3103950135 hasIssue "11" @default.
• W3103950135 hasLocation W31039501351 @default.
• W3103950135 hasLocation W31039501352 @default.
• W3103950135 hasLocation W31039501353 @default.
• W3103950135 hasOpenAccess W3103950135 @default.
• W3103950135 hasPrimaryLocation W31039501351 @default.
• W3103950135 hasRelatedWork W1523310174 @default.
• W3103950135 hasRelatedWork W2013223288 @default.
• W3103950135 hasRelatedWork W2375584271 @default.

• next