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- W3103957364 endingPage "1340" @default.
- W3103957364 startingPage "1340" @default.
- W3103957364 abstract "G-quadruplex (G4) is the non-canonical secondary structure of DNA and RNA formed by guanine-rich sequences. G4-forming sequences are abundantly located in telomeric regions and in the promoter and untranslated regions (UTR) of cancer-related genes, such as RAS and MYC. Extensive research has suggested that G4 is a potential molecular target for cancer therapy. Here, we reviewed G4 ligands as photosensitizers for cancer photodynamic therapy (PDT), which is a minimally invasive therapeutic approach. The photosensitizers, such as porphyrins, were found to be highly toxic against cancer cells via the generation of reactive oxidative species (ROS) upon photo-irradiation. Several porphyrin derivatives and analogs, such as phthalocyanines, which can generate ROS upon photo-irradiation, have been reported to act as G4 ligands. Therefore, they have been implicated as promising photosensitizers that can selectively break down cancer-related DNA and RNA forming G4. In this review, we majorly focused on the potential application of G4 ligands as photosensitizers, which would provide a novel strategy for PDT, especially molecularly targeted PDT (mtPDT)." @default.
- W3103957364 created "2020-11-23" @default.
- W3103957364 creator A5001510505 @default.
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- W3103957364 creator A5072063421 @default.
- W3103957364 date "2020-11-12" @default.
- W3103957364 modified "2023-10-11" @default.
- W3103957364 title "Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy" @default.
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- W3103957364 doi "https://doi.org/10.3390/genes11111340" @default.
- W3103957364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7697063" @default.
- W3103957364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33198362" @default.
- W3103957364 hasPublicationYear "2020" @default.
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