FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3103973006> ?p ?o ?g. }

• W3103973006 endingPage "1046" @default.
• W3103973006 startingPage "1046" @default.
• W3103973006 abstract "Amorphous solid dispersions (SDs) containing poorly soluble tamoxifen dispersed in a meth(acrylate) copolymer combination were proposed as a controlled release system. The objective of this work was to investigate the characteristics and performance of the tamoxifen–polymer mixture and evaluate the changes in functionality through a supersaturating dissolution study condition while comparing it to a physical mixture at a fixed drug-loading proportion. Two polymers, Eudragit® L 100 and Eudragit® RL 100, were used to prepare SDs with a 1:1 polymer ratio, containing 10%, 20%, or 30% (wt/wt%) of tamoxifen, by the solvent evaporation method. A physical mixture containing 30% of tamoxifen was also prepared for comparison. SDs were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. Dissolution tests were conducted under non-sink conditions to verify the occurrence of drug recrystallization upon its release. Solid-state characterizations confirmed that the drug was in the amorphous state within the polymeric matrix. Tamoxifen release in an acidic medium was mainly affected by the increase in drug concentration caused by the possible loss of interactions that characterize the main polymer functionalities. At pH 7.4, supersaturation was slowly achieved while also contributing to the increase in the kinetic solubility of the drug. The physical mixture demonstrated the best overall performance, suggesting that the polymeric interactions may have negatively affected the drug release. The combination of polymers in the composing SD proved to be a promising strategy to tailor the delivery of poorly soluble drugs. Our study highlights important information on the behavior of tamoxifen as a poorly soluble drug in supersaturating dissolution conditions while released from SD systems." @default.
• W3103973006 created "2020-11-23" @default.
• W3103973006 creator A5001238375 @default.
• W3103973006 creator A5002821166 @default.
• W3103973006 creator A5039214205 @default.
• W3103973006 creator A5040209491 @default.
• W3103973006 creator A5047766848 @default.
• W3103973006 creator A5067227026 @default.
• W3103973006 creator A5072472271 @default.
• W3103973006 creator A5082291455 @default.
• W3103973006 date "2020-11-17" @default.
• W3103973006 modified "2023-09-27" @default.
• W3103973006 title "Enhanced Dissolution Efficiency of Tamoxifen Combined with Methacrylate Copolymers in Amorphous Solid Dispersions" @default.
• W3103973006 cites W1974354511 @default.
• W3103973006 cites W1987451410 @default.
• W3103973006 cites W2017817746 @default.
• W3103973006 cites W2020798890 @default.
• W3103973006 cites W2030670872 @default.
• W3103973006 cites W2069470150 @default.
• W3103973006 cites W2082048773 @default.
• W3103973006 cites W2088883959 @default.
• W3103973006 cites W2091347891 @default.
• W3103973006 cites W2095014752 @default.
• W3103973006 cites W2143950817 @default.
• W3103973006 cites W2191912059 @default.
• W3103973006 cites W2200680635 @default.
• W3103973006 cites W2224558131 @default.
• W3103973006 cites W2233376589 @default.
• W3103973006 cites W2243158166 @default.
• W3103973006 cites W2253675932 @default.
• W3103973006 cites W2327186139 @default.
• W3103973006 cites W2481005045 @default.
• W3103973006 cites W2513223537 @default.
• W3103973006 cites W2514772139 @default.
• W3103973006 cites W2524704535 @default.
• W3103973006 cites W2556496813 @default.
• W3103973006 cites W2586352836 @default.
• W3103973006 cites W2605793257 @default.
• W3103973006 cites W2742271390 @default.
• W3103973006 cites W2748709776 @default.
• W3103973006 cites W2897051859 @default.
• W3103973006 cites W2902956542 @default.
• W3103973006 cites W2903612425 @default.
• W3103973006 cites W2913392672 @default.
• W3103973006 cites W2951501552 @default.
• W3103973006 cites W2955461563 @default.
• W3103973006 cites W2980594258 @default.
• W3103973006 cites W2994212130 @default.
• W3103973006 cites W2994845290 @default.
• W3103973006 cites W3014331878 @default.
• W3103973006 cites W3045454585 @default.
• W3103973006 cites W775997396 @default.
• W3103973006 doi "https://doi.org/10.3390/cryst10111046" @default.
• W3103973006 hasPublicationYear "2020" @default.
• W3103973006 type Work @default.
• W3103973006 sameAs 3103973006 @default.
• W3103973006 citedByCount "0" @default.
• W3103973006 crossrefType "journal-article" @default.
• W3103973006 hasAuthorship W3103973006A5001238375 @default.
• W3103973006 hasAuthorship W3103973006A5002821166 @default.
• W3103973006 hasAuthorship W3103973006A5039214205 @default.
• W3103973006 hasAuthorship W3103973006A5040209491 @default.
• W3103973006 hasAuthorship W3103973006A5047766848 @default.
• W3103973006 hasAuthorship W3103973006A5067227026 @default.
• W3103973006 hasAuthorship W3103973006A5072472271 @default.
• W3103973006 hasAuthorship W3103973006A5082291455 @default.
• W3103973006 hasBestOaLocation W31039730061 @default.
• W3103973006 hasConcept C121332964 @default.
• W3103973006 hasConcept C127413603 @default.
• W3103973006 hasConcept C155574463 @default.
• W3103973006 hasConcept C15920480 @default.
• W3103973006 hasConcept C159985019 @default.
• W3103973006 hasConcept C178790620 @default.
• W3103973006 hasConcept C185592680 @default.
• W3103973006 hasConcept C192562407 @default.
• W3103973006 hasConcept C39519442 @default.
• W3103973006 hasConcept C42360764 @default.
• W3103973006 hasConcept C46275449 @default.
• W3103973006 hasConcept C521977710 @default.
• W3103973006 hasConcept C56052488 @default.
• W3103973006 hasConcept C88380143 @default.
• W3103973006 hasConcept C97355855 @default.
• W3103973006 hasConceptScore W3103973006C121332964 @default.
• W3103973006 hasConceptScore W3103973006C127413603 @default.
• W3103973006 hasConceptScore W3103973006C155574463 @default.
• W3103973006 hasConceptScore W3103973006C15920480 @default.
• W3103973006 hasConceptScore W3103973006C159985019 @default.
• W3103973006 hasConceptScore W3103973006C178790620 @default.
• W3103973006 hasConceptScore W3103973006C185592680 @default.
• W3103973006 hasConceptScore W3103973006C192562407 @default.
• W3103973006 hasConceptScore W3103973006C39519442 @default.
• W3103973006 hasConceptScore W3103973006C42360764 @default.
• W3103973006 hasConceptScore W3103973006C46275449 @default.
• W3103973006 hasConceptScore W3103973006C521977710 @default.
• W3103973006 hasConceptScore W3103973006C56052488 @default.
• W3103973006 hasConceptScore W3103973006C88380143 @default.
• W3103973006 hasConceptScore W3103973006C97355855 @default.
• W3103973006 hasIssue "11" @default.

• next