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- W3103996087 endingPage "110179" @default.
- W3103996087 startingPage "110179" @default.
- W3103996087 abstract "The dysfunction of dopaminergic signaling is associated with several neurological disorders. The use of pharmacological agents that interact with this signaling system may be employed to understand mechanisms underlying such disorders. Nutritional status can impact dopamine reuptake, receptor affinity, transporter activity, and the effects of drugs that bind to dopamine receptors or interact with dopaminergic system. Here we evaluated the effects of quinpirole (a dopamine D2/D3 receptor agonist) exposure on fed and non-fed zebrafish larvae. Zebrafish larvae (6 days post-fertilization, dpf) were exposed to quinpirole (5.5, 16.7, and 50.0 μM) or water (control group) for one hour. To evaluate the effect of feeding status on quinpirole exposure, the experiments were performed on fed and non-fed animals, a between subject experimental design. Both fed and non-fed quinpirole treated larvae exhibited increased erratic movements compared to controls in an open tank exploration task. No alterations were observed on the main parameters of exploratory behavior and swim activity for non-fed larvae treated with quinpirole compared to controls. However, fed animals exposed to quinpirole exhibited increased locomotor activity, anxiety-like behavior, and repetitive circular movements when compared to controls and non-fed exposed animals. In addition, we observed quinpirole exposure to have no effects on morphological parameters and heartbeat, but to impair optomotor responses in both fed and non-fed larvae compared to control. We also found quinpirole effects to interact with feeding status, as quinpirole-treated fed larvae improved while quinpirole treated non-fed larvae impaired their avoidance reaction towards an aversive stimulus. These results indicate that the behavioral effects of quinpirole exposure depended upon feeding status. They showed that consumption of food, a naturally rewarding stimulus known to engage the dopaminergic system, made this neurotransmitter system more susceptible to quinpirole's effects." @default.
- W3103996087 created "2020-11-23" @default.
- W3103996087 creator A5022898574 @default.
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- W3103996087 creator A5068680303 @default.
- W3103996087 creator A5081332370 @default.
- W3103996087 date "2021-06-01" @default.
- W3103996087 modified "2023-10-18" @default.
- W3103996087 title "Feeding status alters exploratory and anxiety-like behaviors in zebrafish larvae exposed to quinpirole" @default.
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- W3103996087 doi "https://doi.org/10.1016/j.pnpbp.2020.110179" @default.
- W3103996087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33212194" @default.
- W3103996087 hasPublicationYear "2021" @default.
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