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• W3104057788 abstract "Abstract Past studies concluded that Atoh7 is critical for the emergence of the retinal ganglion cell (RGC) lineage in the developing retina, whereas Pou4f2 and Isl1 function in RGC differentiation. Atoh7 is expressed in a subset of retinal progenitor cells (RPCs) and is considered a competence factor for the RGC fate, but the molecular properties of these RPCs have not been well characterized. In this study, we first used conventional RNA-seq to investigate transcriptomic changes in Atoh7 -, Pou4f2 -, and Isl1 -null retinas at embryonic (E) day 14.5 and identified the differentially expressed genes (DEGs), which expanded our understanding of the scope of downstream events. We then performed single cell RNA-seq (scRNA-seq) on E13.5 and E17.5 wild-type and Atoh7 -null retinal cells. Clustering analysis not only correctly identified known cell types at these developmental stages but also revealed a transitional cell state which was marked by Atoh7 and genes for other lineages in a highly overlapping fashion and shared by all early developmental trajectories. Further, analysis of the Atoh7 -null retina revealed that, unlike previously believed, the RGC lineage still progressed considerably and a substantial amount of RGC-specific gene expression still occurred. Thus, Atoh7 likely collaborates with other factors to shepherd the transitional RPCs to the RGC lineage by competing with other lineage factors and activating RGC-specific genes. This study thus provides significant insights into the nature of RPC competence for different retinal cell fates and revises our current view on the emergence of the RGC lineage." @default.
• W3104057788 created "2020-11-23" @default.
• W3104057788 creator A5013297039 @default.
• W3104057788 creator A5025354819 @default.
• W3104057788 creator A5030515675 @default.
• W3104057788 creator A5031515832 @default.
• W3104057788 creator A5050319998 @default.
• W3104057788 creator A5051054140 @default.
• W3104057788 creator A5059425433 @default.
• W3104057788 creator A5068006897 @default.
• W3104057788 creator A5075877965 @default.
• W3104057788 creator A5087669521 @default.
• W3104057788 date "2020-02-27" @default.
• W3104057788 modified "2023-09-24" @default.
• W3104057788 title "Single cell transcriptomics reveals lineage trajectory of the retinal ganglion cells in wild-type and<i>Atoh7</i>-null retinas" @default.
• W3104057788 cites W1499209009 @default.
• W3104057788 cites W1835721351 @default.
• W3104057788 cites W1846704321 @default.
• W3104057788 cites W1895998181 @default.
• W3104057788 cites W1960895270 @default.
• W3104057788 cites W1964163541 @default.
• W3104057788 cites W1964264655 @default.
• W3104057788 cites W1969698545 @default.
• W3104057788 cites W1972468954 @default.
• W3104057788 cites W1974421363 @default.
• W3104057788 cites W1975728537 @default.
• W3104057788 cites W1977949300 @default.
• W3104057788 cites W1979440192 @default.
• W3104057788 cites W1979780441 @default.
• W3104057788 cites W1980980049 @default.
• W3104057788 cites W1985912987 @default.
• W3104057788 cites W1988623932 @default.
• W3104057788 cites W1988939522 @default.
• W3104057788 cites W1989324842 @default.
• W3104057788 cites W1989972710 @default.
• W3104057788 cites W1990433739 @default.
• W3104057788 cites W1994750743 @default.
• W3104057788 cites W1995854663 @default.
• W3104057788 cites W1997272979 @default.
• W3104057788 cites W1997987643 @default.
• W3104057788 cites W1999254348 @default.
• W3104057788 cites W2011341845 @default.
• W3104057788 cites W2013741270 @default.
• W3104057788 cites W2015177334 @default.
• W3104057788 cites W2016491409 @default.
• W3104057788 cites W2017350075 @default.
• W3104057788 cites W2023958768 @default.
• W3104057788 cites W2025187874 @default.
• W3104057788 cites W2031986169 @default.
• W3104057788 cites W2032751739 @default.
• W3104057788 cites W2033585891 @default.
• W3104057788 cites W2033937556 @default.
• W3104057788 cites W2035806445 @default.
• W3104057788 cites W2037603093 @default.
• W3104057788 cites W2038480702 @default.
• W3104057788 cites W2041598409 @default.
• W3104057788 cites W2041949935 @default.
• W3104057788 cites W2043180700 @default.
• W3104057788 cites W2045318076 @default.
• W3104057788 cites W2046728523 @default.
• W3104057788 cites W2048275890 @default.
• W3104057788 cites W2055725555 @default.
• W3104057788 cites W2059344357 @default.
• W3104057788 cites W2059678501 @default.
• W3104057788 cites W2059679976 @default.
• W3104057788 cites W2060460558 @default.
• W3104057788 cites W2060997280 @default.
• W3104057788 cites W2061122481 @default.
• W3104057788 cites W2061808806 @default.
• W3104057788 cites W2065594360 @default.
• W3104057788 cites W2066187363 @default.
• W3104057788 cites W2066556283 @default.
• W3104057788 cites W2067470032 @default.
• W3104057788 cites W2068973951 @default.
• W3104057788 cites W2071255383 @default.
• W3104057788 cites W2076166032 @default.
• W3104057788 cites W2076780019 @default.
• W3104057788 cites W2076900594 @default.
• W3104057788 cites W2077066627 @default.
• W3104057788 cites W2078186919 @default.
• W3104057788 cites W2079269655 @default.
• W3104057788 cites W2080832893 @default.
• W3104057788 cites W2086607543 @default.
• W3104057788 cites W2087493271 @default.
• W3104057788 cites W2099545629 @default.
• W3104057788 cites W2101728847 @default.
• W3104057788 cites W2102212449 @default.
• W3104057788 cites W2107394975 @default.
• W3104057788 cites W2110741244 @default.
• W3104057788 cites W2114104545 @default.
• W3104057788 cites W2117383884 @default.
• W3104057788 cites W2125253773 @default.
• W3104057788 cites W2125506149 @default.
• W3104057788 cites W2125509137 @default.
• W3104057788 cites W2126271676 @default.
• W3104057788 cites W2129618668 @default.
• W3104057788 cites W2130993929 @default.
• W3104057788 cites W2133465414 @default.
• W3104057788 cites W2136855213 @default.
• W3104057788 cites W2145984966 @default.

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