Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104073471> ?p ?o ?g. }
- W3104073471 endingPage "1131" @default.
- W3104073471 startingPage "1124" @default.
- W3104073471 abstract "Context Nephrolithiasis is a major public health problem worldwide and Fu-Fang-Jin-Qian-Cao granules (FFJQC) is a traditional Chinese herbal formula that is used to treat nephrolithiasis. The main component of nephrolithiasis is calcium oxalate (CaOx) and the epithelial-mesenchymal transition (EMT) shown to play a crucial role in CaOx-induced kidney injury. However, the mechanism underlying the therapeutic effect of FFJQC on the CaOx-induced renal EMT is unknown.Objective This study explores the therapeutic benefits and mechanism of FFJQC in oxalate-induced kidney injury.Materials and methods 60 male C57BL/6 mice were used in this experiment and divided into 6 groups. A mouse kidney stone model was created by intraperitoneal injection of glyoxylate at a dose of 100 mg/kg for 6 days. The standardized FFJQC was used to treat mouse crystal kidney injury by gavage at 1.35 and 2.7 g/kg, respectively. Western blotting and immunostaining for E-cadherin, cytokeratin 18 (CK18), vimentin, smooth muscle α-actin (α-SMA) and transforming growth factor β (TGF-β)/Smad pathway were conducted on renal tissues.Results Following CaOx-induced kidney injury, the levels of E-cadherin and CK18 in kidney decreased, while vimentin and α-SMA levels increased. The FFJQC treatment increased the levels of E-cadherin and CK18 and decreased vimentin and α-SMA levels in varying degrees. What’s more, the FFJQC reduced the expression of CaOx-induced fibrosis marker collagen II.Conclusion FFJQC alleviated the CaOx-induced renal EMT and fibrosis by regulating TGF-β/smad pathway. Therefore, the FFJQC is an important traditional Chinese medicine for the treatment of CaOx-induced renal injury and fibrosis." @default.
- W3104073471 created "2020-11-23" @default.
- W3104073471 creator A5007009918 @default.
- W3104073471 creator A5008932038 @default.
- W3104073471 creator A5017541508 @default.
- W3104073471 creator A5018273025 @default.
- W3104073471 creator A5022255776 @default.
- W3104073471 creator A5022361178 @default.
- W3104073471 creator A5031845006 @default.
- W3104073471 creator A5039181018 @default.
- W3104073471 creator A5043776328 @default.
- W3104073471 creator A5047862807 @default.
- W3104073471 creator A5066316680 @default.
- W3104073471 creator A5072680782 @default.
- W3104073471 date "2020-01-01" @default.
- W3104073471 modified "2023-10-14" @default.
- W3104073471 title "Fu-Fang-Jin-Qian-Cao herbal granules protect against the calcium oxalate-induced renal EMT by inhibiting the TGF-β/smad pathway" @default.
- W3104073471 cites W1599415696 @default.
- W3104073471 cites W1635984088 @default.
- W3104073471 cites W1795437907 @default.
- W3104073471 cites W1916263719 @default.
- W3104073471 cites W1980397922 @default.
- W3104073471 cites W1996118868 @default.
- W3104073471 cites W1996150255 @default.
- W3104073471 cites W2005983388 @default.
- W3104073471 cites W2013688634 @default.
- W3104073471 cites W2035653659 @default.
- W3104073471 cites W2035838858 @default.
- W3104073471 cites W2061354001 @default.
- W3104073471 cites W2109863501 @default.
- W3104073471 cites W2110886621 @default.
- W3104073471 cites W2112341317 @default.
- W3104073471 cites W2130067314 @default.
- W3104073471 cites W2135109450 @default.
- W3104073471 cites W2148184356 @default.
- W3104073471 cites W2189664213 @default.
- W3104073471 cites W2252909698 @default.
- W3104073471 cites W2333274776 @default.
- W3104073471 cites W2342679639 @default.
- W3104073471 cites W2474031604 @default.
- W3104073471 cites W2562640620 @default.
- W3104073471 cites W2572240149 @default.
- W3104073471 cites W2583313510 @default.
- W3104073471 cites W2590062395 @default.
- W3104073471 cites W2590254599 @default.
- W3104073471 cites W2604393403 @default.
- W3104073471 cites W2607449852 @default.
- W3104073471 cites W2753589739 @default.
- W3104073471 cites W2767543713 @default.
- W3104073471 cites W2792649607 @default.
- W3104073471 cites W2792686807 @default.
- W3104073471 cites W2799758397 @default.
- W3104073471 cites W2805909690 @default.
- W3104073471 cites W2888371620 @default.
- W3104073471 cites W2912971126 @default.
- W3104073471 cites W837672717 @default.
- W3104073471 doi "https://doi.org/10.1080/13880209.2020.1844241" @default.
- W3104073471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7671650" @default.
- W3104073471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33191819" @default.
- W3104073471 hasPublicationYear "2020" @default.
- W3104073471 type Work @default.
- W3104073471 sameAs 3104073471 @default.
- W3104073471 citedByCount "11" @default.
- W3104073471 countsByYear W31040734712021 @default.
- W3104073471 countsByYear W31040734712022 @default.
- W3104073471 countsByYear W31040734712023 @default.
- W3104073471 crossrefType "journal-article" @default.
- W3104073471 hasAuthorship W3104073471A5007009918 @default.
- W3104073471 hasAuthorship W3104073471A5008932038 @default.
- W3104073471 hasAuthorship W3104073471A5017541508 @default.
- W3104073471 hasAuthorship W3104073471A5018273025 @default.
- W3104073471 hasAuthorship W3104073471A5022255776 @default.
- W3104073471 hasAuthorship W3104073471A5022361178 @default.
- W3104073471 hasAuthorship W3104073471A5031845006 @default.
- W3104073471 hasAuthorship W3104073471A5039181018 @default.
- W3104073471 hasAuthorship W3104073471A5043776328 @default.
- W3104073471 hasAuthorship W3104073471A5047862807 @default.
- W3104073471 hasAuthorship W3104073471A5066316680 @default.
- W3104073471 hasAuthorship W3104073471A5072680782 @default.
- W3104073471 hasBestOaLocation W31040734711 @default.
- W3104073471 hasConcept C118131993 @default.
- W3104073471 hasConcept C121608353 @default.
- W3104073471 hasConcept C126322002 @default.
- W3104073471 hasConcept C147447768 @default.
- W3104073471 hasConcept C151730666 @default.
- W3104073471 hasConcept C204232928 @default.
- W3104073471 hasConcept C2776179656 @default.
- W3104073471 hasConcept C2779013556 @default.
- W3104073471 hasConcept C2779343474 @default.
- W3104073471 hasConcept C2780091579 @default.
- W3104073471 hasConcept C2780159080 @default.
- W3104073471 hasConcept C2780559512 @default.
- W3104073471 hasConcept C2781080636 @default.
- W3104073471 hasConcept C502942594 @default.
- W3104073471 hasConcept C519063684 @default.
- W3104073471 hasConcept C71924100 @default.
- W3104073471 hasConcept C76419328 @default.
- W3104073471 hasConcept C86803240 @default.