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• W3104126768 endingPage "1128" @default.
• W3104126768 startingPage "1128" @default.
• W3104126768 abstract "Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in patients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed." @default.
• W3104126768 created "2020-11-23" @default.
• W3104126768 creator A5018932718 @default.
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• W3104126768 creator A5062402018 @default.
• W3104126768 creator A5073996886 @default.
• W3104126768 creator A5089876539 @default.
• W3104126768 date "2020-11-13" @default.
• W3104126768 modified "2023-10-06" @default.
• W3104126768 title "Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies" @default.
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