Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104156022> ?p ?o ?g. }
- W3104156022 endingPage "2764" @default.
- W3104156022 startingPage "2758" @default.
- W3104156022 abstract "Functional proteins must fold with some minimal stability to a structure that can perform a biochemical task. Here we use a simple model to investigate the relationship between the stability requirement and the capacity of a protein to evolve the function of binding to a ligand. Although our model contains no built-in tradeoff between stability and function, proteins evolved function more efficiently when the stability requirement was relaxed. Proteins with both high stability and high function evolved more efficiently when the stability requirement was gradually increased than when there was constant selection for high stability. These results show that in our model, the evolution of function is enhanced by allowing proteins to explore sequences corresponding to marginally stable structures, and that it is easier to improve stability while maintaining high function than to improve function while maintaining high stability. Our model also demonstrates that even in the absence of a fundamental biophysical tradeoff between stability and function, the speed with which function can evolve is limited by the stability requirement imposed on the protein." @default.
- W3104156022 created "2020-11-23" @default.
- W3104156022 creator A5031224365 @default.
- W3104156022 creator A5070411498 @default.
- W3104156022 creator A5081226757 @default.
- W3104156022 creator A5091068534 @default.
- W3104156022 date "2004-05-01" @default.
- W3104156022 modified "2023-10-14" @default.
- W3104156022 title "Stability and the Evolvability of Function in a Model Protein" @default.
- W3104156022 cites W1551404386 @default.
- W3104156022 cites W1575215071 @default.
- W3104156022 cites W1964381094 @default.
- W3104156022 cites W1964529071 @default.
- W3104156022 cites W1967769940 @default.
- W3104156022 cites W1973722782 @default.
- W3104156022 cites W1975017420 @default.
- W3104156022 cites W1975833119 @default.
- W3104156022 cites W1980045457 @default.
- W3104156022 cites W1982198083 @default.
- W3104156022 cites W1992579032 @default.
- W3104156022 cites W1997325518 @default.
- W3104156022 cites W2025408902 @default.
- W3104156022 cites W2028113659 @default.
- W3104156022 cites W2029377901 @default.
- W3104156022 cites W2031728341 @default.
- W3104156022 cites W2032014168 @default.
- W3104156022 cites W2040390777 @default.
- W3104156022 cites W2045777307 @default.
- W3104156022 cites W2051815940 @default.
- W3104156022 cites W2059168883 @default.
- W3104156022 cites W2069504710 @default.
- W3104156022 cites W2072843928 @default.
- W3104156022 cites W2089088187 @default.
- W3104156022 cites W2092409871 @default.
- W3104156022 cites W2114899912 @default.
- W3104156022 cites W2120705912 @default.
- W3104156022 cites W2135769863 @default.
- W3104156022 cites W2153454419 @default.
- W3104156022 cites W2156470306 @default.
- W3104156022 cites W2166523933 @default.
- W3104156022 cites W2171610577 @default.
- W3104156022 cites W2399031292 @default.
- W3104156022 cites W2591756625 @default.
- W3104156022 cites W2592822795 @default.
- W3104156022 cites W4295224975 @default.
- W3104156022 cites W4299702438 @default.
- W3104156022 doi "https://doi.org/10.1016/s0006-3495(04)74329-5" @default.
- W3104156022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15111394" @default.
- W3104156022 hasPublicationYear "2004" @default.
- W3104156022 type Work @default.
- W3104156022 sameAs 3104156022 @default.
- W3104156022 citedByCount "87" @default.
- W3104156022 countsByYear W31041560222012 @default.
- W3104156022 countsByYear W31041560222013 @default.
- W3104156022 countsByYear W31041560222014 @default.
- W3104156022 countsByYear W31041560222015 @default.
- W3104156022 countsByYear W31041560222016 @default.
- W3104156022 countsByYear W31041560222017 @default.
- W3104156022 countsByYear W31041560222018 @default.
- W3104156022 countsByYear W31041560222019 @default.
- W3104156022 countsByYear W31041560222020 @default.
- W3104156022 countsByYear W31041560222021 @default.
- W3104156022 countsByYear W31041560222022 @default.
- W3104156022 countsByYear W31041560222023 @default.
- W3104156022 crossrefType "journal-article" @default.
- W3104156022 hasAuthorship W3104156022A5031224365 @default.
- W3104156022 hasAuthorship W3104156022A5070411498 @default.
- W3104156022 hasAuthorship W3104156022A5081226757 @default.
- W3104156022 hasAuthorship W3104156022A5091068534 @default.
- W3104156022 hasBestOaLocation W31041560221 @default.
- W3104156022 hasConcept C112972136 @default.
- W3104156022 hasConcept C119857082 @default.
- W3104156022 hasConcept C14036430 @default.
- W3104156022 hasConcept C176147130 @default.
- W3104156022 hasConcept C186060115 @default.
- W3104156022 hasConcept C2988375501 @default.
- W3104156022 hasConcept C41008148 @default.
- W3104156022 hasConcept C54355233 @default.
- W3104156022 hasConcept C86803240 @default.
- W3104156022 hasConcept C95444343 @default.
- W3104156022 hasConceptScore W3104156022C112972136 @default.
- W3104156022 hasConceptScore W3104156022C119857082 @default.
- W3104156022 hasConceptScore W3104156022C14036430 @default.
- W3104156022 hasConceptScore W3104156022C176147130 @default.
- W3104156022 hasConceptScore W3104156022C186060115 @default.
- W3104156022 hasConceptScore W3104156022C2988375501 @default.
- W3104156022 hasConceptScore W3104156022C41008148 @default.
- W3104156022 hasConceptScore W3104156022C54355233 @default.
- W3104156022 hasConceptScore W3104156022C86803240 @default.
- W3104156022 hasConceptScore W3104156022C95444343 @default.
- W3104156022 hasIssue "5" @default.
- W3104156022 hasLocation W31041560221 @default.
- W3104156022 hasLocation W31041560222 @default.
- W3104156022 hasLocation W31041560223 @default.
- W3104156022 hasLocation W31041560224 @default.
- W3104156022 hasLocation W31041560225 @default.
- W3104156022 hasOpenAccess W3104156022 @default.
- W3104156022 hasPrimaryLocation W31041560221 @default.