Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104173634> ?p ?o ?g. }
- W3104173634 abstract "Abstract Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning (“intron definition”) or exon-spanning (“exon definition”) pairs. To understand how exon and intron length and splice site recognition mode impact splicing, we measured splicing rates genome-wide in Drosophila , using metabolic labeling/RNA sequencing and new mathematical models to estimate rates. We found that the modal intron length range of 60-70 nt represents a local maximum of splicing rates, but that much longer exon-defined introns are spliced even faster and more accurately. Surprisingly, we observed low variation in splicing rates across introns in the same gene, suggesting the presence of gene-level influences, and we identified multiple gene level variables associated with splicing rate. Together our data suggest that developmental and stress response genes may have preferentially evolved exon definition in order to enhance rates of splicing." @default.
- W3104173634 created "2020-11-23" @default.
- W3104173634 creator A5000205596 @default.
- W3104173634 creator A5013232960 @default.
- W3104173634 creator A5048799588 @default.
- W3104173634 creator A5073767577 @default.
- W3104173634 creator A5077612907 @default.
- W3104173634 creator A5085186633 @default.
- W3104173634 date "2017-02-13" @default.
- W3104173634 modified "2023-09-30" @default.
- W3104173634 title "The kinetics of pre-mRNA splicing in the Drosophila genome: influence of gene architecture" @default.
- W3104173634 cites W1539868719 @default.
- W3104173634 cites W1767163685 @default.
- W3104173634 cites W1771001171 @default.
- W3104173634 cites W1795468129 @default.
- W3104173634 cites W1863643864 @default.
- W3104173634 cites W1899949781 @default.
- W3104173634 cites W1955741675 @default.
- W3104173634 cites W1969744517 @default.
- W3104173634 cites W1971229919 @default.
- W3104173634 cites W1972255859 @default.
- W3104173634 cites W1974365473 @default.
- W3104173634 cites W1974966784 @default.
- W3104173634 cites W1982118908 @default.
- W3104173634 cites W1985567287 @default.
- W3104173634 cites W1986152803 @default.
- W3104173634 cites W1989482194 @default.
- W3104173634 cites W1990377497 @default.
- W3104173634 cites W1994200894 @default.
- W3104173634 cites W2012451954 @default.
- W3104173634 cites W2013321581 @default.
- W3104173634 cites W2014517533 @default.
- W3104173634 cites W2023648355 @default.
- W3104173634 cites W2025836692 @default.
- W3104173634 cites W2026657651 @default.
- W3104173634 cites W2027699344 @default.
- W3104173634 cites W2028630156 @default.
- W3104173634 cites W2037429489 @default.
- W3104173634 cites W2037589637 @default.
- W3104173634 cites W2038894647 @default.
- W3104173634 cites W2044597770 @default.
- W3104173634 cites W2049022227 @default.
- W3104173634 cites W2051242197 @default.
- W3104173634 cites W2051490611 @default.
- W3104173634 cites W2051604556 @default.
- W3104173634 cites W2052981827 @default.
- W3104173634 cites W2053057991 @default.
- W3104173634 cites W2053220812 @default.
- W3104173634 cites W2057368600 @default.
- W3104173634 cites W2068469513 @default.
- W3104173634 cites W2074097219 @default.
- W3104173634 cites W2076825429 @default.
- W3104173634 cites W2077874719 @default.
- W3104173634 cites W2078531707 @default.
- W3104173634 cites W2082096431 @default.
- W3104173634 cites W2083833254 @default.
- W3104173634 cites W2088440342 @default.
- W3104173634 cites W2095180721 @default.
- W3104173634 cites W2097065948 @default.
- W3104173634 cites W2099591857 @default.
- W3104173634 cites W2099835330 @default.
- W3104173634 cites W2100794056 @default.
- W3104173634 cites W2102619694 @default.
- W3104173634 cites W2109362348 @default.
- W3104173634 cites W2118150714 @default.
- W3104173634 cites W2119603839 @default.
- W3104173634 cites W2123123598 @default.
- W3104173634 cites W2124985265 @default.
- W3104173634 cites W2126508095 @default.
- W3104173634 cites W2128043711 @default.
- W3104173634 cites W2129218346 @default.
- W3104173634 cites W2135485520 @default.
- W3104173634 cites W2145700028 @default.
- W3104173634 cites W2145762379 @default.
- W3104173634 cites W2147491566 @default.
- W3104173634 cites W2155115337 @default.
- W3104173634 cites W2157009395 @default.
- W3104173634 cites W2159730169 @default.
- W3104173634 cites W2160955060 @default.
- W3104173634 cites W2163256056 @default.
- W3104173634 cites W2165521581 @default.
- W3104173634 cites W2169456326 @default.
- W3104173634 cites W2171581216 @default.
- W3104173634 cites W2274600402 @default.
- W3104173634 cites W2305558625 @default.
- W3104173634 cites W2479003569 @default.
- W3104173634 cites W2508929473 @default.
- W3104173634 cites W2731682345 @default.
- W3104173634 cites W2772065758 @default.
- W3104173634 cites W4238840384 @default.
- W3104173634 doi "https://doi.org/10.1101/107995" @default.
- W3104173634 hasPublicationYear "2017" @default.
- W3104173634 type Work @default.
- W3104173634 sameAs 3104173634 @default.
- W3104173634 citedByCount "1" @default.
- W3104173634 countsByYear W31041736342019 @default.
- W3104173634 crossrefType "posted-content" @default.
- W3104173634 hasAuthorship W3104173634A5000205596 @default.
- W3104173634 hasAuthorship W3104173634A5013232960 @default.
- W3104173634 hasAuthorship W3104173634A5048799588 @default.