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- W3104194019 abstract "Adult tissues contain label-retaining cells (LRCs), which are relatively slow-cycling and considered to represent a property of tissue stem cells (SCs). In the ocular surface epithelium, LRCs are present in the limbus and conjunctival fornix; however, the character of these LRCs remains unclear, owing to lack of appropriate molecular markers. Using three CreER transgenic mouse lines, we demonstrate that the ocular surface epithelium accommodates spatially distinct populations with different cell division dynamics. In the limbus, long-lived Slc1a3CreER-labeled SCs either migrate centripetally toward the central cornea or slowly expand their clones laterally within the limbal region. In the central cornea, non-LRCs labeled with Dlx1CreER and K14CreER behave as short-lived progenitor cells. The conjunctival epithelium in the bulbar, fornix and palpebral compartment is regenerated by regionally unique SC populations. Severe damage to the cornea leads to the cancellation of SC compartments and conjunctivalization, whereas milder limbal injury induces a rapid increase of laterally expanding clones in the limbus. Taken together, our work defines compartmentalized multiple SC/progenitor populations of the mouse eye in homeostasis and their behavioral changes in response to injury." @default.
- W3104194019 created "2020-11-23" @default.
- W3104194019 creator A5043730992 @default.
- W3104194019 creator A5063146571 @default.
- W3104194019 creator A5091498997 @default.
- W3104194019 date "2020-12-15" @default.
- W3104194019 modified "2023-10-16" @default.
- W3104194019 title "Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium" @default.
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- W3104194019 doi "https://doi.org/10.1242/dev.197590" @default.
- W3104194019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7758628" @default.
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- W3104194019 hasPublicationYear "2020" @default.
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