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- W3104211081 endingPage "1531" @default.
- W3104211081 startingPage "1511" @default.
- W3104211081 abstract "Covering: 2000 up to 2020This review presents select recent advances in the medicinal chemistry of complex natural products that are prepared by total synthesis. The underlying studies highlight enabling divergent synthetic strategies and methods that permit the systematic medicinal chemistry studies of key analogues bearing deep-seated structural changes not readily accessible by semisynthetic or biosynthetic means. Select and recent examples are detailed where the key structural changes are designed to improve defined properties or to overcome an intrinsic limitation of the natural product itself. In the examples presented, the synthetic efforts provided supernatural products, a term first introduced by our colleague Ryan Shenvi (Synlett, 2016, 27, 1145-1164), with properties superseding the parent natural product. The design principles and approaches for creating the supernatural products are highlighted with an emphasis on the properties addressed that include those that improve activity or potency, increase selectivity, enhance durability, broaden the spectrum of activity, improve chemical or metabolic stability, overcome limiting physical properties, add mechanisms of action, enhance PK properties, overcome drug resistance, and/or improve in vivo efficacy. Some such improvements may be regarded by some as iterative enhancements whereas others, we believe, truly live up to their characterization as supernatural products. Most such efforts are also accompanied by advances in synthetic organic chemistry, inspiring the development of new synthetic methodology and providing supernatural products with improved synthetic accessibility." @default.
- W3104211081 created "2020-11-23" @default.
- W3104211081 creator A5048049268 @default.
- W3104211081 creator A5049235255 @default.
- W3104211081 date "2020-01-01" @default.
- W3104211081 modified "2023-10-17" @default.
- W3104211081 title "The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry" @default.
- W3104211081 cites W1602597014 @default.
- W3104211081 cites W1796900355 @default.
- W3104211081 cites W1964308996 @default.
- W3104211081 cites W1965694039 @default.
- W3104211081 cites W1965964706 @default.
- W3104211081 cites W1966487507 @default.
- W3104211081 cites W1967807712 @default.
- W3104211081 cites W1968393195 @default.
- W3104211081 cites W1968656660 @default.
- W3104211081 cites W1968773075 @default.
- W3104211081 cites W1968818108 @default.
- W3104211081 cites W1969398599 @default.
- W3104211081 cites W1970276483 @default.
- W3104211081 cites W1972164028 @default.
- W3104211081 cites W1972370905 @default.
- W3104211081 cites W1973917220 @default.
- W3104211081 cites W1974542094 @default.
- W3104211081 cites W1975218610 @default.
- W3104211081 cites W1976436192 @default.
- W3104211081 cites W1977217144 @default.
- W3104211081 cites W1977874814 @default.
- W3104211081 cites W1979687682 @default.
- W3104211081 cites W1980521536 @default.
- W3104211081 cites W1983466621 @default.
- W3104211081 cites W1983706370 @default.
- W3104211081 cites W1984374097 @default.
- W3104211081 cites W1986272790 @default.
- W3104211081 cites W1989772178 @default.
- W3104211081 cites W1991659350 @default.
- W3104211081 cites W1993976101 @default.
- W3104211081 cites W1995014382 @default.
- W3104211081 cites W1995179418 @default.
- W3104211081 cites W1995767891 @default.
- W3104211081 cites W1995783411 @default.
- W3104211081 cites W1996074150 @default.
- W3104211081 cites W1997453147 @default.
- W3104211081 cites W1998078889 @default.
- W3104211081 cites W1999577892 @default.
- W3104211081 cites W2001596560 @default.
- W3104211081 cites W2002097360 @default.
- W3104211081 cites W2005305616 @default.
- W3104211081 cites W2005572157 @default.
- W3104211081 cites W2005643237 @default.
- W3104211081 cites W2005721855 @default.
- W3104211081 cites W2006808796 @default.
- W3104211081 cites W2008185727 @default.
- W3104211081 cites W2010763622 @default.
- W3104211081 cites W2011334290 @default.
- W3104211081 cites W2011682232 @default.
- W3104211081 cites W2016247915 @default.
- W3104211081 cites W2018341228 @default.
- W3104211081 cites W2020070718 @default.
- W3104211081 cites W2021897757 @default.
- W3104211081 cites W2025234237 @default.
- W3104211081 cites W2025623674 @default.
- W3104211081 cites W2027320048 @default.
- W3104211081 cites W2028366831 @default.
- W3104211081 cites W2028677895 @default.
- W3104211081 cites W2030087792 @default.
- W3104211081 cites W2030964931 @default.
- W3104211081 cites W2033606087 @default.
- W3104211081 cites W2035152060 @default.
- W3104211081 cites W2036024184 @default.
- W3104211081 cites W2037345786 @default.
- W3104211081 cites W2038539775 @default.
- W3104211081 cites W2038673694 @default.
- W3104211081 cites W2039145109 @default.
- W3104211081 cites W2040998642 @default.
- W3104211081 cites W2041190905 @default.
- W3104211081 cites W2041769918 @default.
- W3104211081 cites W2041785554 @default.
- W3104211081 cites W2043244040 @default.
- W3104211081 cites W2044416815 @default.
- W3104211081 cites W2045153874 @default.
- W3104211081 cites W2045174337 @default.
- W3104211081 cites W2045768089 @default.
- W3104211081 cites W2046624507 @default.
- W3104211081 cites W2048404184 @default.
- W3104211081 cites W2050502887 @default.
- W3104211081 cites W2051757495 @default.
- W3104211081 cites W2052147832 @default.
- W3104211081 cites W2052151051 @default.
- W3104211081 cites W2053317505 @default.
- W3104211081 cites W2055278617 @default.
- W3104211081 cites W2055328779 @default.
- W3104211081 cites W2063315796 @default.
- W3104211081 cites W2063444920 @default.
- W3104211081 cites W2064950951 @default.
- W3104211081 cites W2065368875 @default.
- W3104211081 cites W2069377050 @default.
- W3104211081 cites W2069635625 @default.