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• W3104261526 endingPage "78" @default.
• W3104261526 startingPage "69" @default.
• W3104261526 abstract "Fetal alcohol spectrum disorder (FASD) is caused by prenatal alcohol exposure (PAE), the intake of ethanol (C2 H5 OH) during pregnancy. Features of FASD cover a range of structural and functional defects including congenital heart defects (CHDs). Folic acid and choline, contributors of methyl groups to one-carbon metabolism (OCM), prevent CHDs in humans. Using our avian model of FASD, we have previously reported that betaine, another methyl donor downstream of choline, prevents CHDs. The CHD preventions are substantial but incomplete. Ethanol causes oxidative stress as well as depleting methyl groups for OCM to support DNA methylation and other epigenetic alterations. To identify more compounds that can safely and effectively prevent CHDs and other effects of PAE, we tested glutathione (GSH), a compound that regulates OCM and is known as a master antioxidant.Quail embryos injected with a single dose of ethanol at gastrulation exhibited congenital defects including CHDs similar to those identified in FASD individuals. GSH injected simultaneously with ethanol not only prevented CHDs, but also improved survival and prevented other PAE-induced defects. Assays of hearts at 8 days (HH stage 34) of quail development, when the heart normally has developed 4-chambers, showed that this single dose of PAE reduced global DNA methylation. GSH supplementation concurrent with PAE normalized global DNA methylation levels. The same assays performed on quail hearts at 3 days (HH stage 19-20) of development, showed no difference in global DNA methylation between controls, ethanol-treated, GSH alone, and GSH plus ethanol-treated cohorts.GSH supplementation shows promise to inhibit effects of PAE by improving survival, reducing the incidence of morphological defects including CHDs, and preventing global hypomethylation of DNA in heart tissues." @default.
• W3104261526 created "2020-11-23" @default.
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• W3104261526 date "2021-01-01" @default.
• W3104261526 modified "2023-10-15" @default.
• W3104261526 title "Glutathione Protects the Developing Heart from Defects and Global DNA Hypomethylation Induced by Prenatal Alcohol Exposure" @default.
• W3104261526 cites W1007786270 @default.
• W3104261526 cites W110481942 @default.
• W3104261526 cites W1525993893 @default.
• W3104261526 cites W1532048738 @default.
• W3104261526 cites W1583945683 @default.
• W3104261526 cites W1598267874 @default.
• W3104261526 cites W1785122941 @default.
• W3104261526 cites W1854705458 @default.
• W3104261526 cites W1868621517 @default.
• W3104261526 cites W1891967301 @default.
• W3104261526 cites W1978890796 @default.
• W3104261526 cites W1987108538 @default.
• W3104261526 cites W1987111014 @default.
• W3104261526 cites W1991426288 @default.
• W3104261526 cites W1993000387 @default.
• W3104261526 cites W1997860363 @default.
• W3104261526 cites W2002805664 @default.
• W3104261526 cites W2003578569 @default.
• W3104261526 cites W2004078197 @default.
• W3104261526 cites W2004839314 @default.
• W3104261526 cites W2008982730 @default.
• W3104261526 cites W2015228025 @default.
• W3104261526 cites W2018404966 @default.
• W3104261526 cites W2020814529 @default.
• W3104261526 cites W202227517 @default.
• W3104261526 cites W2028290095 @default.
• W3104261526 cites W2035697450 @default.
• W3104261526 cites W2037880480 @default.
• W3104261526 cites W2040740850 @default.
• W3104261526 cites W2041225825 @default.
• W3104261526 cites W2043037824 @default.
• W3104261526 cites W2053548069 @default.
• W3104261526 cites W2054129051 @default.
• W3104261526 cites W2055698030 @default.
• W3104261526 cites W2058703570 @default.
• W3104261526 cites W2061463822 @default.
• W3104261526 cites W2063006038 @default.
• W3104261526 cites W2069880894 @default.
• W3104261526 cites W2071516487 @default.
• W3104261526 cites W2077591369 @default.
• W3104261526 cites W2084823009 @default.
• W3104261526 cites W2084902871 @default.
• W3104261526 cites W2088624891 @default.
• W3104261526 cites W2089626640 @default.
• W3104261526 cites W2108710787 @default.
• W3104261526 cites W2109165312 @default.
• W3104261526 cites W2113823919 @default.
• W3104261526 cites W2117936472 @default.
• W3104261526 cites W2120935789 @default.
• W3104261526 cites W2122003546 @default.
• W3104261526 cites W2124746853 @default.
• W3104261526 cites W2142157072 @default.
• W3104261526 cites W2151396320 @default.
• W3104261526 cites W2153812249 @default.
• W3104261526 cites W2157283442 @default.
• W3104261526 cites W2160283039 @default.
• W3104261526 cites W2161029943 @default.
• W3104261526 cites W2168671633 @default.
• W3104261526 cites W2169714384 @default.
• W3104261526 cites W2266929960 @default.
• W3104261526 cites W2320983896 @default.
• W3104261526 cites W2466683448 @default.
• W3104261526 cites W2491383955 @default.
• W3104261526 cites W2492998196 @default.
• W3104261526 cites W2520176641 @default.
• W3104261526 cites W2520894026 @default.
• W3104261526 cites W2526148162 @default.
• W3104261526 cites W2589060457 @default.
• W3104261526 cites W2591152818 @default.
• W3104261526 cites W2601288368 @default.
• W3104261526 cites W2610514232 @default.
• W3104261526 cites W2616707192 @default.
• W3104261526 cites W2724364885 @default.
• W3104261526 cites W2751768647 @default.
• W3104261526 cites W2761186974 @default.
• W3104261526 cites W2773020747 @default.
• W3104261526 cites W2782220253 @default.
• W3104261526 cites W2785897769 @default.
• W3104261526 cites W2791558379 @default.
• W3104261526 cites W2794333713 @default.

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