Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104269743> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3104269743 endingPage "113768" @default.
- W3104269743 startingPage "113768" @default.
- W3104269743 abstract "Forced degradation/stress degradation studies of ibrutinib drug were done in hydrolytic (acidic, alkaline and neutral), thermal, photolytic and oxidative degradation conditions in different temperature conditions as per International Conference on Harmonization (ICH) guideline Q1A(R2) in order to identify and characterize degradation products (DPs) of ibrutinib. The study revealed that ibrutinib is extremely sensitive to oxidative degradation even at room temperature. The drug substance is highly sensitive to alkaline hydrolysis and susceptible to acidic hydrolysis at 80 °C temperature condition, whereas found stable in neutral, photolytic and thermal stress conditions. Successful separation of ibrutinib and its ten degradation products formed during stress degradation condition were observed using Waters Acquity UPLC C-18 stationary phase (100 mm × 2.1 mm, 1.7 μm) with gradient elution using mobile phase consisting of Eluent-A: ammonium acetate (20 mm, pH-6) and Eluent-B: acetonitrile. The detection was carried out at 215 nm wavelength. Flow rate was set at 0.3 mL/min with injection volume of 5 μL. The drug substance degraded to one degradation product (DP-I) in acidic hydrolysis, five DPs (DP-I, DP-II, DP-V, DP-VIII and DP-IX) in basic hydrolysis and five DPs (DP-III, DP-IV, DP-VI, DP-VII and DP-X) in oxidative degradation condition. A novel and highly sensitive HRMS/MS/TOF method was developed to identify and characterize all the ten DPs formed during stress study. All the DPs were characterized using ESI positive mode. Except DP-I, all the degradation products formed were found to be new degradation impurities and their fragmentation pathways have never been reported earlier. The proposed mechanism and pathway of degradation products of ibrutinib were discussed and outlined." @default.
- W3104269743 created "2020-11-23" @default.
- W3104269743 creator A5016480596 @default.
- W3104269743 creator A5025074274 @default.
- W3104269743 creator A5057350836 @default.
- W3104269743 creator A5061287077 @default.
- W3104269743 creator A5085145540 @default.
- W3104269743 date "2021-02-01" @default.
- W3104269743 modified "2023-10-02" @default.
- W3104269743 title "LC and LC–MS/MS studies for identification and characterization of new degradation products of ibrutinib and elucidation of their degradation pathway" @default.
- W3104269743 cites W2108206643 @default.
- W3104269743 cites W2154066874 @default.
- W3104269743 cites W2163690533 @default.
- W3104269743 cites W2195033221 @default.
- W3104269743 cites W2937591749 @default.
- W3104269743 cites W3014405281 @default.
- W3104269743 cites W3014486626 @default.
- W3104269743 cites W3034566816 @default.
- W3104269743 doi "https://doi.org/10.1016/j.jpba.2020.113768" @default.
- W3104269743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33279300" @default.
- W3104269743 hasPublicationYear "2021" @default.
- W3104269743 type Work @default.
- W3104269743 sameAs 3104269743 @default.
- W3104269743 citedByCount "16" @default.
- W3104269743 countsByYear W31042697432020 @default.
- W3104269743 countsByYear W31042697432021 @default.
- W3104269743 countsByYear W31042697432022 @default.
- W3104269743 countsByYear W31042697432023 @default.
- W3104269743 crossrefType "journal-article" @default.
- W3104269743 hasAuthorship W3104269743A5016480596 @default.
- W3104269743 hasAuthorship W3104269743A5025074274 @default.
- W3104269743 hasAuthorship W3104269743A5057350836 @default.
- W3104269743 hasAuthorship W3104269743A5061287077 @default.
- W3104269743 hasAuthorship W3104269743A5085145540 @default.
- W3104269743 hasConcept C126322002 @default.
- W3104269743 hasConcept C178790620 @default.
- W3104269743 hasConcept C179998833 @default.
- W3104269743 hasConcept C185592680 @default.
- W3104269743 hasConcept C2777463227 @default.
- W3104269743 hasConcept C2777682752 @default.
- W3104269743 hasConcept C2777938653 @default.
- W3104269743 hasConcept C2778461978 @default.
- W3104269743 hasConcept C2779679103 @default.
- W3104269743 hasConcept C2779878957 @default.
- W3104269743 hasConcept C2780782300 @default.
- W3104269743 hasConcept C41008148 @default.
- W3104269743 hasConcept C43617362 @default.
- W3104269743 hasConcept C71924100 @default.
- W3104269743 hasConcept C76155785 @default.
- W3104269743 hasConcept C94412978 @default.
- W3104269743 hasConceptScore W3104269743C126322002 @default.
- W3104269743 hasConceptScore W3104269743C178790620 @default.
- W3104269743 hasConceptScore W3104269743C179998833 @default.
- W3104269743 hasConceptScore W3104269743C185592680 @default.
- W3104269743 hasConceptScore W3104269743C2777463227 @default.
- W3104269743 hasConceptScore W3104269743C2777682752 @default.
- W3104269743 hasConceptScore W3104269743C2777938653 @default.
- W3104269743 hasConceptScore W3104269743C2778461978 @default.
- W3104269743 hasConceptScore W3104269743C2779679103 @default.
- W3104269743 hasConceptScore W3104269743C2779878957 @default.
- W3104269743 hasConceptScore W3104269743C2780782300 @default.
- W3104269743 hasConceptScore W3104269743C41008148 @default.
- W3104269743 hasConceptScore W3104269743C43617362 @default.
- W3104269743 hasConceptScore W3104269743C71924100 @default.
- W3104269743 hasConceptScore W3104269743C76155785 @default.
- W3104269743 hasConceptScore W3104269743C94412978 @default.
- W3104269743 hasLocation W31042697431 @default.
- W3104269743 hasOpenAccess W3104269743 @default.
- W3104269743 hasPrimaryLocation W31042697431 @default.
- W3104269743 hasRelatedWork W1979512650 @default.
- W3104269743 hasRelatedWork W2037599510 @default.
- W3104269743 hasRelatedWork W2056980537 @default.
- W3104269743 hasRelatedWork W2087046738 @default.
- W3104269743 hasRelatedWork W2089660391 @default.
- W3104269743 hasRelatedWork W2109904578 @default.
- W3104269743 hasRelatedWork W2119552130 @default.
- W3104269743 hasRelatedWork W2256031060 @default.
- W3104269743 hasRelatedWork W2382440586 @default.
- W3104269743 hasRelatedWork W2599388867 @default.
- W3104269743 hasVolume "194" @default.
- W3104269743 isParatext "false" @default.
- W3104269743 isRetracted "false" @default.
- W3104269743 magId "3104269743" @default.
- W3104269743 workType "article" @default.