FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104324008> ?p ?o ?g. }

• W3104324008 endingPage "155" @default.
• W3104324008 startingPage "133" @default.
• W3104324008 abstract "The deduction of design principles for complex biological functionalities has been a source of constant interest in the fields of systems and synthetic biology. A number of approaches have been adopted, to identify the space of network structures or topologies that can demonstrate a specific desired functionality, ranging from brute force to systems theory-based methodologies. The former approach involves performing a search among all possible combinations of network structures, as well as the parameters underlying the rate kinetics for a given form of network. In contrast to the search-oriented approach in brute force studies, the present chapter introduces a generic approach inspired by systems theory to deduce the network structures for a particular biological functionality. As a first step, depending on the functionality and the type of network in consideration, a measure of goodness of attainment is deduced by defining performance parameters. These parameters are computed for the most ideal case to obtain the necessary condition for the given functionality. The necessary conditions are then mapped as specific requirements on the parameters of the dynamical system underlying the network. Following this, admissible minimal structures are deduced. The proposed methodology does not assume any particular rate kinetics in this case for deducing the admissible network structures notwithstanding a minimum set of assumptions on the rate kinetics. The problem of computing the ideal set of parameter/s or rate constants, unlike the problem of topology identification, depends on the particular rate kinetics assumed for the given network. In this case, instead of a computationally exhaustive brute force search of the parameter space, a topology-functionality specific optimization problem can be solved. The objective function along with the feasible region bounded by the motif specific constraints amounts to solving a non-convex optimization program leading to non-unique parameter sets. To exemplify our approach, we adopt the functionality of adaptation, and demonstrate how network topologies that can achieve adaptation can be identified using such a systems-theoretic approach. The outcomes, in this case, i.e., minimum network structures for adaptation, are in agreement with the brute force results and other studies in literature." @default.
• W3104324008 created "2020-11-23" @default.
• W3104324008 creator A5011489319 @default.
• W3104324008 creator A5014178891 @default.
• W3104324008 creator A5064793183 @default.
• W3104324008 date "2020-11-13" @default.
• W3104324008 modified "2023-09-23" @default.
• W3104324008 title "Systems-Theoretic Approaches to Design Biological Networks with Desired Functionalities" @default.
• W3104324008 cites W1970661255 @default.
• W3104324008 cites W1974347855 @default.
• W3104324008 cites W2000566983 @default.
• W3104324008 cites W2023165891 @default.
• W3104324008 cites W2053345816 @default.
• W3104324008 cites W2072454019 @default.
• W3104324008 cites W2077480167 @default.
• W3104324008 cites W2090341259 @default.
• W3104324008 cites W2101420429 @default.
• W3104324008 cites W2117056464 @default.
• W3104324008 cites W2123973944 @default.
• W3104324008 cites W2153624566 @default.
• W3104324008 cites W2247294682 @default.
• W3104324008 cites W2276582555 @default.
• W3104324008 cites W2802389030 @default.
• W3104324008 cites W2808806431 @default.
• W3104324008 cites W2953258579 @default.
• W3104324008 cites W2973361953 @default.
• W3104324008 cites W2975521369 @default.
• W3104324008 cites W3101211237 @default.
• W3104324008 cites W4234350010 @default.
• W3104324008 cites W2331733516 @default.
• W3104324008 doi "https://doi.org/10.1007/978-1-0716-0822-7_11" @default.
• W3104324008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33180299" @default.
• W3104324008 hasPublicationYear "2020" @default.
• W3104324008 type Work @default.
• W3104324008 sameAs 3104324008 @default.
• W3104324008 citedByCount "6" @default.
• W3104324008 countsByYear W31043240082021 @default.
• W3104324008 countsByYear W31043240082022 @default.
• W3104324008 countsByYear W31043240082023 @default.
• W3104324008 crossrefType "book-chapter" @default.
• W3104324008 hasAuthorship W3104324008A5011489319 @default.
• W3104324008 hasAuthorship W3104324008A5014178891 @default.
• W3104324008 hasAuthorship W3104324008A5064793183 @default.
• W3104324008 hasConcept C127413603 @default.
• W3104324008 hasConcept C183696295 @default.
• W3104324008 hasConcept C28225019 @default.
• W3104324008 hasConcept C41008148 @default.
• W3104324008 hasConcept C70721500 @default.
• W3104324008 hasConcept C80444323 @default.
• W3104324008 hasConcept C86803240 @default.
• W3104324008 hasConceptScore W3104324008C127413603 @default.
• W3104324008 hasConceptScore W3104324008C183696295 @default.
• W3104324008 hasConceptScore W3104324008C28225019 @default.
• W3104324008 hasConceptScore W3104324008C41008148 @default.
• W3104324008 hasConceptScore W3104324008C70721500 @default.
• W3104324008 hasConceptScore W3104324008C80444323 @default.
• W3104324008 hasConceptScore W3104324008C86803240 @default.
• W3104324008 hasLocation W31043240081 @default.
• W3104324008 hasOpenAccess W3104324008 @default.
• W3104324008 hasPrimaryLocation W31043240081 @default.
• W3104324008 hasRelatedWork W1537384694 @default.
• W3104324008 hasRelatedWork W2120947607 @default.
• W3104324008 hasRelatedWork W2151674698 @default.
• W3104324008 hasRelatedWork W2162401749 @default.
• W3104324008 hasRelatedWork W2392953011 @default.
• W3104324008 hasRelatedWork W2460716018 @default.
• W3104324008 hasRelatedWork W2468446668 @default.
• W3104324008 hasRelatedWork W3003422837 @default.
• W3104324008 hasRelatedWork W3199739261 @default.
• W3104324008 hasRelatedWork W2101255175 @default.
• W3104324008 isParatext "false" @default.
• W3104324008 isRetracted "false" @default.
• W3104324008 magId "3104324008" @default.
• W3104324008 workType "book-chapter" @default.