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- W3104336998 abstract "Tropomyosin receptor kinases (TRKs) are promising cancer therapeutic targets. Chen ( J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.0c01342) report the discovery of CG416 and CG428 as two potent small-molecule proteolysis-targeting chimera (PROTAC) degraders selective for TRKA over TRKB and TRKC. CG416 and CG428 are valuable research tool compounds for in vitro and in vivo studies and promising lead compounds for further optimization." @default.
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- W3104336998 date "2020-11-18" @default.
- W3104336998 modified "2023-09-23" @default.
- W3104336998 title "Selectively Targeting Tropomyosin Receptor Kinase A (TRKA) via PROTACs" @default.
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- W3104336998 doi "https://doi.org/10.1021/acs.jmedchem.0c01947" @default.
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