FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104391374> ?p ?o ?g. }

• W3104391374 abstract "Abstract In the telencephalon of adult zebrafish, the inhibitor of DNA binding 1 ( id1 ) gene is expressed in radial glial cells (RGCs), behaving as neural stem cells (NSCs), during constitutive and regenerative neurogenesis. Id1 controls the balance between resting and proliferating states of RGCs by promoting quiescence. Here, we identified a phylogenetically conserved cis-regulatory module (CRM) mediating the specific expression of id1 in RGCs. Systematic deletion mapping and mutation of conserved transcription factor binding sites in stable transgenic zebrafish lines reveal that this CRM operates via conserved smad1/5 and 4 binding motifs (SBMs) under both homeostatic and regenerative conditions. Transcriptome analysis of injured and uninjured telencephala as well as pharmacological inhibition experiments identify a crucial role of bone morphogenetic protein (BMP) signaling for the function of the CRM. Our data highlight that BMP signals control id1 expression and thus NSC proliferation during constitutive and induced neurogenesis." @default.
• W3104391374 created "2020-11-23" @default.
• W3104391374 creator A5003927719 @default.
• W3104391374 creator A5005441156 @default.
• W3104391374 creator A5008219858 @default.
• W3104391374 creator A5025069596 @default.
• W3104391374 creator A5037533131 @default.
• W3104391374 creator A5041137450 @default.
• W3104391374 creator A5070654230 @default.
• W3104391374 creator A5077237161 @default.
• W3104391374 creator A5085883751 @default.
• W3104391374 date "2019-10-02" @default.
• W3104391374 modified "2023-09-25" @default.
• W3104391374 title "Bone morphogenetic protein signaling regulates Id1 mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module" @default.
• W3104391374 cites W1496014351 @default.
• W3104391374 cites W1548483220 @default.
• W3104391374 cites W1851235737 @default.
• W3104391374 cites W1964692745 @default.
• W3104391374 cites W1964891995 @default.
• W3104391374 cites W1967380741 @default.
• W3104391374 cites W1979921085 @default.
• W3104391374 cites W1980337975 @default.
• W3104391374 cites W1982649864 @default.
• W3104391374 cites W1983461332 @default.
• W3104391374 cites W1985257221 @default.
• W3104391374 cites W1991156103 @default.
• W3104391374 cites W1994377715 @default.
• W3104391374 cites W1997915808 @default.
• W3104391374 cites W2001494846 @default.
• W3104391374 cites W2006232178 @default.
• W3104391374 cites W2012968697 @default.
• W3104391374 cites W2016748069 @default.
• W3104391374 cites W2017120033 @default.
• W3104391374 cites W2018219363 @default.
• W3104391374 cites W2020733002 @default.
• W3104391374 cites W2036765683 @default.
• W3104391374 cites W2042178048 @default.
• W3104391374 cites W2046157151 @default.
• W3104391374 cites W2056053755 @default.
• W3104391374 cites W2056931310 @default.
• W3104391374 cites W2059805004 @default.
• W3104391374 cites W2065569210 @default.
• W3104391374 cites W2065628921 @default.
• W3104391374 cites W2078226647 @default.
• W3104391374 cites W2084601904 @default.
• W3104391374 cites W2085320324 @default.
• W3104391374 cites W2089333480 @default.
• W3104391374 cites W2089699134 @default.
• W3104391374 cites W2093211742 @default.
• W3104391374 cites W2094972585 @default.
• W3104391374 cites W2105448992 @default.
• W3104391374 cites W2118145895 @default.
• W3104391374 cites W2132527997 @default.
• W3104391374 cites W2134997228 @default.
• W3104391374 cites W2139171962 @default.
• W3104391374 cites W2149972129 @default.
• W3104391374 cites W2153550523 @default.
• W3104391374 cites W2153936388 @default.
• W3104391374 cites W2155008946 @default.
• W3104391374 cites W2156911768 @default.
• W3104391374 cites W2164615751 @default.
• W3104391374 cites W2166920557 @default.
• W3104391374 cites W2167279371 @default.
• W3104391374 cites W2169543334 @default.
• W3104391374 cites W2171603493 @default.
• W3104391374 cites W2181234845 @default.
• W3104391374 cites W2183362624 @default.
• W3104391374 cites W2291059015 @default.
• W3104391374 cites W2764337959 @default.
• W3104391374 cites W2801648979 @default.
• W3104391374 cites W2808592304 @default.
• W3104391374 cites W3123674656 @default.
• W3104391374 cites W4235438234 @default.
• W3104391374 cites W758419723 @default.
• W3104391374 doi "https://doi.org/10.1101/787804" @default.
• W3104391374 hasPublicationYear "2019" @default.
• W3104391374 type Work @default.
• W3104391374 sameAs 3104391374 @default.
• W3104391374 citedByCount "1" @default.
• W3104391374 countsByYear W31043913742022 @default.
• W3104391374 crossrefType "posted-content" @default.
• W3104391374 hasAuthorship W3104391374A5003927719 @default.
• W3104391374 hasAuthorship W3104391374A5005441156 @default.
• W3104391374 hasAuthorship W3104391374A5008219858 @default.
• W3104391374 hasAuthorship W3104391374A5025069596 @default.
• W3104391374 hasAuthorship W3104391374A5037533131 @default.
• W3104391374 hasAuthorship W3104391374A5041137450 @default.
• W3104391374 hasAuthorship W3104391374A5070654230 @default.
• W3104391374 hasAuthorship W3104391374A5077237161 @default.
• W3104391374 hasAuthorship W3104391374A5085883751 @default.
• W3104391374 hasBestOaLocation W31043913741 @default.
• W3104391374 hasConcept C104317684 @default.
• W3104391374 hasConcept C111936080 @default.
• W3104391374 hasConcept C136834591 @default.
• W3104391374 hasConcept C150194340 @default.
• W3104391374 hasConcept C162317418 @default.
• W3104391374 hasConcept C2776878037 @default.
• W3104391374 hasConcept C28328180 @default.
• W3104391374 hasConcept C31507581 @default.
• W3104391374 hasConcept C4746552 @default.

• next