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• W3104398217 startingPage "e0239528" @default.
• W3104398217 abstract "The yeast Saccharomyces cerevisiae has been the subject of many studies aimed at understanding mechanisms of adaptation to environmental stresses. Most of these studies have focused on adaptation to sub-lethal stresses, upon which a stereotypic transcriptional program called the environmental stress response (ESR) is activated. However, the genetic and regulatory factors that underlie the adaptation and survival of yeast cells to stresses that cross the lethality threshold have not been systematically studied. Here, we utilized a combination of gene expression profiling, deletion-library fitness profiling, and experimental evolution to systematically explore adaptation of S . cerevisiae to acute exposure to threshold lethal ethanol concentrations—a stress with important biotechnological implications. We found that yeast cells activate a rapid transcriptional reprogramming process that is likely adaptive in terms of post-stress survival. We also utilized repeated cycles of lethal ethanol exposure to evolve yeast strains with substantially higher ethanol tolerance and survival. Importantly, these strains displayed bulk growth-rates that were indistinguishable from the parental wild-type strain. Remarkably, these hyper-ethanol tolerant strains had reprogrammed their pre-stress gene expression states to match the likely adaptive post-stress response in the wild-type strain. Our studies reveal critical determinants of yeast survival to lethal ethanol stress and highlight potentially general principles that may underlie evolutionary adaptation to lethal stresses in general." @default.
• W3104398217 created "2020-11-23" @default.
• W3104398217 creator A5006245669 @default.
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• W3104398217 date "2020-11-10" @default.
• W3104398217 modified "2023-10-14" @default.
• W3104398217 title "Regulatory and evolutionary adaptation of yeast to acute lethal ethanol stress" @default.
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• W3104398217 doi "https://doi.org/10.1371/journal.pone.0239528" @default.
• W3104398217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7654773" @default.
• W3104398217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33170850" @default.
• W3104398217 hasPublicationYear "2020" @default.
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