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- W3104429558 abstract "We review the challenges of next-generation therapeutics for both systemic and localised delivery to brain tumours and discuss how recent engineering advances may be used to enhance brain penetration of systemic delivery therapies. The unmet clinical need which drug delivery seeks to address is discussed with reference to the therapy obstacles that the intra-tumour heterogeneity of glioma present. The unmet chemistry and biomedical engineering challenge to develop controlled release therapeutics is appraised, with commentary on current success/failures in systemic carrier-mediated delivery, including receptor-targeted, cell-based, blood-brain-barrier disrupting and MRI-guided focused ultrasound. Localised therapeutic delivery is a relatively under-studied research avenue and is discussed with reference to existing technologies in preclinical development. These include convection-enhanced delivery, alternative catheter delivery, and neuro-surgically applied delivery systems such as polymeric hydrogels and interstitial spray. A myriad of nano-scale therapeutic delivery systems is emerging as potential future medicines for malignant brain tumours. Such biomedically-engineered systems will increasingly feature in next-generation neuro-oncological clinical trials to deliver repurposed and experimental therapeutics, aimed at achieving therapeutic drug concentrations in the brain, with associated mortality and morbidity benefits for patients." @default.
- W3104429558 created "2020-11-23" @default.
- W3104429558 creator A5010860660 @default.
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- W3104429558 creator A5078715871 @default.
- W3104429558 creator A5091194683 @default.
- W3104429558 date "2020-12-01" @default.
- W3104429558 modified "2023-09-26" @default.
- W3104429558 title "Biomedical engineering approaches to enhance therapeutic delivery for malignant glioma" @default.
- W3104429558 cites W1414886268 @default.
- W3104429558 cites W1511957901 @default.
- W3104429558 cites W1569973057 @default.
- W3104429558 cites W1582873515 @default.
- W3104429558 cites W1591465785 @default.
- W3104429558 cites W1598943454 @default.
- W3104429558 cites W1843302206 @default.
- W3104429558 cites W1865373725 @default.
- W3104429558 cites W1901198588 @default.
- W3104429558 cites W1947261965 @default.
- W3104429558 cites W1966726954 @default.
- W3104429558 cites W1969328947 @default.
- W3104429558 cites W1970239046 @default.
- W3104429558 cites W1971964492 @default.
- W3104429558 cites W1973544766 @default.
- W3104429558 cites W1976970322 @default.
- W3104429558 cites W1980808550 @default.
- W3104429558 cites W1983800816 @default.
- W3104429558 cites W1985800624 @default.
- W3104429558 cites W1989889052 @default.
- W3104429558 cites W2002771831 @default.
- W3104429558 cites W2004049846 @default.
- W3104429558 cites W2005068136 @default.
- W3104429558 cites W2008653558 @default.
- W3104429558 cites W2010664558 @default.
- W3104429558 cites W2011139878 @default.
- W3104429558 cites W2016082816 @default.
- W3104429558 cites W2019243633 @default.
- W3104429558 cites W2024611377 @default.
- W3104429558 cites W2030141189 @default.
- W3104429558 cites W2041187942 @default.
- W3104429558 cites W2043106681 @default.
- W3104429558 cites W2044013857 @default.
- W3104429558 cites W2048898424 @default.
- W3104429558 cites W2049149624 @default.
- W3104429558 cites W2054077061 @default.
- W3104429558 cites W2066467291 @default.
- W3104429558 cites W2066912376 @default.
- W3104429558 cites W2071052390 @default.
- W3104429558 cites W2073077789 @default.
- W3104429558 cites W2075039638 @default.
- W3104429558 cites W2088473419 @default.
- W3104429558 cites W2090845010 @default.
- W3104429558 cites W2091857781 @default.
- W3104429558 cites W2093390598 @default.
- W3104429558 cites W2099431752 @default.
- W3104429558 cites W2104496626 @default.
- W3104429558 cites W2107160883 @default.
- W3104429558 cites W2111498289 @default.
- W3104429558 cites W2115924220 @default.
- W3104429558 cites W2117327657 @default.
- W3104429558 cites W2125987139 @default.
- W3104429558 cites W2126184619 @default.
- W3104429558 cites W2126363249 @default.
- W3104429558 cites W2128234521 @default.
- W3104429558 cites W2134680580 @default.
- W3104429558 cites W2135062838 @default.
- W3104429558 cites W2138063382 @default.
- W3104429558 cites W2145046260 @default.
- W3104429558 cites W2145444071 @default.
- W3104429558 cites W2152460583 @default.
- W3104429558 cites W2152525754 @default.
- W3104429558 cites W2153312916 @default.
- W3104429558 cites W2153771870 @default.
- W3104429558 cites W2154096369 @default.
- W3104429558 cites W2155765426 @default.
- W3104429558 cites W2156990171 @default.
- W3104429558 cites W2164788523 @default.
- W3104429558 cites W2171802467 @default.
- W3104429558 cites W2178835613 @default.
- W3104429558 cites W2211734418 @default.
- W3104429558 cites W2214752215 @default.
- W3104429558 cites W2255479470 @default.
- W3104429558 cites W2266347643 @default.
- W3104429558 cites W2293134842 @default.
- W3104429558 cites W2319243539 @default.
- W3104429558 cites W2332715237 @default.
- W3104429558 cites W2335360019 @default.
- W3104429558 cites W2337875347 @default.
- W3104429558 cites W2344644350 @default.
- W3104429558 cites W2344850880 @default.
- W3104429558 cites W2393820387 @default.
- W3104429558 cites W2405899780 @default.
- W3104429558 cites W2570696586 @default.
- W3104429558 cites W2591624943 @default.
- W3104429558 cites W2606594196 @default.
- W3104429558 cites W2626252985 @default.