FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104451825> ?p ?o ?g. }

• W3104451825 endingPage "396" @default.
• W3104451825 startingPage "388" @default.
• W3104451825 abstract "Abstract The JIPANG study is a randomized phase III study of pemetrexed/cisplatin (Pem/Cis) versus vinorelbine/cisplatin (Vnr/Cis) for completely resected stage II‐IIIA non‐squamous non‐small cell lung cancer (Ns‐NSCLC). This study did not meet the primary endpoint (recurrence‐free survival, RFS) but Pem/Cis had a similar efficacy to Vnr/Cis with a better tolerability. Tumor mutation burden (TMB) is thought to have a predictive value of immune checkpoint inhibitors. However, the relevance of TMB to cytotoxic chemotherapy remains unknown. This exploratory study investigates the relationship between tumor mutation profiles and clinical outcome of Pem/Cis. Formalin‐fixed, paraffin‐embedded tumor tissues (n = 389) were obtained from the patients. Mutation status of tissue DNA was analyzed by targeted deep sequencing. Epidermal growth factor receptor ( EGFR) mutations were detected frequently in Ns‐NSCLC (139/374). Patients without any EGFR mutations experienced longer RFS in the Pem/Cis arm versus Vnr/Cis arms. Pem/Cis in patients with high TMB (≥12‐16 mut/Mb) tended to have improved survival. In patients with wild‐type EGFR , TMB ≥ 12 mut/Mb was significantly associated with improved RFS with Pem/Cis versus Vnr/Cis (not reached vs 52.5 months; hazard ratio (HR) 0.477). It could be proposed that TMB was predictive of RFS benefit with Pem/Cis versus Vnr/Cis in Ns‐NSCLC. Further investigation is required to determine whether TMB combined with EGFR mutation status could be used as a predictive biomarker." @default.
• W3104451825 created "2020-11-23" @default.
• W3104451825 creator A5001014240 @default.
• W3104451825 creator A5001765159 @default.
• W3104451825 creator A5003648443 @default.
• W3104451825 creator A5004282323 @default.
• W3104451825 creator A5009084626 @default.
• W3104451825 creator A5010927080 @default.
• W3104451825 creator A5015524135 @default.
• W3104451825 creator A5015604127 @default.
• W3104451825 creator A5019175407 @default.
• W3104451825 creator A5020448557 @default.
• W3104451825 creator A5021333939 @default.
• W3104451825 creator A5024261346 @default.
• W3104451825 creator A5027580659 @default.
• W3104451825 creator A5032337115 @default.
• W3104451825 creator A5037461196 @default.
• W3104451825 creator A5045498137 @default.
• W3104451825 creator A5054884728 @default.
• W3104451825 creator A5057044706 @default.
• W3104451825 creator A5067259938 @default.
• W3104451825 creator A5069224038 @default.
• W3104451825 creator A5073758146 @default.
• W3104451825 creator A5073895575 @default.
• W3104451825 creator A5074950427 @default.
• W3104451825 creator A5078287634 @default.
• W3104451825 creator A5080218166 @default.
• W3104451825 creator A5081654329 @default.
• W3104451825 creator A5083865202 @default.
• W3104451825 creator A5084260472 @default.
• W3104451825 date "2020-11-30" @default.
• W3104451825 modified "2023-09-30" @default.
• W3104451825 title "Tumor mutation burden as a biomarker for lung cancer patients treated with pemetrexed and cisplatin (the JIPANG‐TR)" @default.
• W3104451825 cites W2016710415 @default.
• W3104451825 cites W2028433016 @default.
• W3104451825 cites W2044563319 @default.
• W3104451825 cites W2049553585 @default.
• W3104451825 cites W2081095165 @default.
• W3104451825 cites W2085061992 @default.
• W3104451825 cites W2086064725 @default.
• W3104451825 cites W2093799017 @default.
• W3104451825 cites W2099237130 @default.
• W3104451825 cites W2104504726 @default.
• W3104451825 cites W2131348261 @default.
• W3104451825 cites W2413675862 @default.
• W3104451825 cites W2547187744 @default.
• W3104451825 cites W2560367415 @default.
• W3104451825 cites W2797675588 @default.
• W3104451825 cites W2808103385 @default.
• W3104451825 cites W2885229054 @default.
• W3104451825 cites W2890112546 @default.
• W3104451825 cites W2912418732 @default.
• W3104451825 cites W2947876098 @default.
• W3104451825 cites W2970981278 @default.
• W3104451825 cites W2971003754 @default.
• W3104451825 cites W3024772225 @default.
• W3104451825 cites W3104451825 @default.
• W3104451825 doi "https://doi.org/10.1111/cas.14730" @default.
• W3104451825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7780021" @default.
• W3104451825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33185928" @default.
• W3104451825 hasPublicationYear "2020" @default.
• W3104451825 type Work @default.
• W3104451825 sameAs 3104451825 @default.
• W3104451825 citedByCount "13" @default.
• W3104451825 countsByYear W31044518252020 @default.
• W3104451825 countsByYear W31044518252021 @default.
• W3104451825 countsByYear W31044518252022 @default.
• W3104451825 countsByYear W31044518252023 @default.
• W3104451825 crossrefType "journal-article" @default.
• W3104451825 hasAuthorship W3104451825A5001014240 @default.
• W3104451825 hasAuthorship W3104451825A5001765159 @default.
• W3104451825 hasAuthorship W3104451825A5003648443 @default.
• W3104451825 hasAuthorship W3104451825A5004282323 @default.
• W3104451825 hasAuthorship W3104451825A5009084626 @default.
• W3104451825 hasAuthorship W3104451825A5010927080 @default.
• W3104451825 hasAuthorship W3104451825A5015524135 @default.
• W3104451825 hasAuthorship W3104451825A5015604127 @default.
• W3104451825 hasAuthorship W3104451825A5019175407 @default.
• W3104451825 hasAuthorship W3104451825A5020448557 @default.
• W3104451825 hasAuthorship W3104451825A5021333939 @default.
• W3104451825 hasAuthorship W3104451825A5024261346 @default.
• W3104451825 hasAuthorship W3104451825A5027580659 @default.
• W3104451825 hasAuthorship W3104451825A5032337115 @default.
• W3104451825 hasAuthorship W3104451825A5037461196 @default.
• W3104451825 hasAuthorship W3104451825A5045498137 @default.
• W3104451825 hasAuthorship W3104451825A5054884728 @default.
• W3104451825 hasAuthorship W3104451825A5057044706 @default.
• W3104451825 hasAuthorship W3104451825A5067259938 @default.
• W3104451825 hasAuthorship W3104451825A5069224038 @default.
• W3104451825 hasAuthorship W3104451825A5073758146 @default.
• W3104451825 hasAuthorship W3104451825A5073895575 @default.
• W3104451825 hasAuthorship W3104451825A5074950427 @default.
• W3104451825 hasAuthorship W3104451825A5078287634 @default.
• W3104451825 hasAuthorship W3104451825A5080218166 @default.
• W3104451825 hasAuthorship W3104451825A5081654329 @default.
• W3104451825 hasAuthorship W3104451825A5083865202 @default.
• W3104451825 hasAuthorship W3104451825A5084260472 @default.
• W3104451825 hasBestOaLocation W31044518251 @default.

• next